| Project/Area Number |
18K15531
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Bagge Emilie 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (30813795)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | mitochondria / mtdna / bipolar disorder / sequencing / epigenetics / mitochondrial DNA / PVT / nucleus accumbens / neuropsychiatry / mutation |
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| Outline of Final Research Achievements |
Mutations in mitochondrial genes have been found in some patients with bipolar disorder (BD). Mitochondria are the energy-producing units of the cell and without functional mitochondria the cell itself is at risk of dysfunction. Mutations in mitochondrial genes are thought to cause mutations in a specific type of DNA, mtDNA, that is present within mitochondria.
In this research project we implemented a method that allows us to look at all mutations in mtDNA from very small pieces of tissue, and thereby create a "brain-wide view" of mtDNA mutations. By analysing the brains of mice that have a mutation in a mitochondrial gene found in BD patients, we found that specific brain regions are very sensitive to have mutations. These brain regions have previously been found to be involved in BD. This indicates that mitochondria and mitochondrial regulation is different across brain regions and may contribute to neuropsychiatric disorders.
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| Academic Significance and Societal Importance of the Research Achievements |
The method we have implemented allows us to examine mtDNA from smaller tissue pieces than previously without the need for biasing approaches. Our brain-wide view of mtDNA mutations add new depth to mitochondrial research and better our understanding of the molecular mechanisms of bipolar disorder.
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