| Project/Area Number |
18K15543
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 光音響イメージング / 腸管虚血 / 組織内酸素飽和度 / 腸管虚血再灌流 / 酸素飽和度 / Interventional radiology |
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| Outline of Final Research Achievements |
In recent years, despite advances in radiological diagnostic methods, early diagnosis of acute intestinal ischemia remains a challenge. During the operation of acute intestinal ischemia, there is no reliable objective marker of intestinal viability to determine the resection margin, thus it is dependent on the subjective and non-quantitative judgment of the surgeon, and requires advanced clinical experience. Photoacoustic imaging (PAI), which has become popular in recent years, enabled imaging and quantification of the degree of tissue oxygenation caused by blood flow information.
Creating a rat model simulating strangulation ileus that is the basis of ischemia/reperfusion intestinal tract, we assessed the tissue oxygen saturation of ischemic intestine after reperfusion. We suggested the possibility of predicting irreversible ischemic injury at any site.
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| Academic Significance and Societal Importance of the Research Achievements |
近年の画像診断の進歩においても急性腸管虚血の早期診断は難しく、虚血腸管の切除に関しては、外科医の主観的、非定量的な判断に委ねられており、高度な臨床経験を要求される。近年普及しつつある光音響イメージングでは生体内における組織内酸素飽和度の可視化及び定量化が可能であり、虚血・再灌流腸管と組織酸素飽和度の関連性を簡便に施行できる光音響イメージングで定量化することは実臨床における不必要な腸管切除の回避、腸管切除範囲の評価になど治療方針の決定に与えるメリットは大きい。
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