The development of lymphatic flow imaging method for the clinical application

• Project/Area Number: 18K15544
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Hamamatsu University School of Medicine (2020); Gifu University (2018-2019)
• Principal Investigator: Tanahashi Yukichi 浜松医科大学, 医学部附属病院, 助教 (40724563)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ダイナミックリンパ管イメージング / リンパ管造影下CT / リンパ管造影下MRI / リンパ管 / CT / MRI / 動物実験 / CT lymphangiography / MR lymphangiography / リンパ管シンチグラフィ

Outline of Final Research Achievements

The optimal CT protocol for intranodal dynamic contrast-enhanced CT lymphangiography was developed using microminipigs. The image quality was compared with the intranodal dynamic contrast-enhanced MR lymphangiography whose efficacy for lymphatic disease is reported. Our result showed that the optimal CT protocol for intranodal dynamic contrast-enhanced CT lymphangiography was dynamic imaging at 5 and 10 minutes after the initiation of contrast media injection. The image quality and visualization of lymphatics were comparable between CT lymphangiography and MR lymphangiography. Our result indicated that intranodal dynamic contrast-enhanced CT lymphangiography may be a good lymphatic imaging and further research will be required.

Academic Significance and Societal Importance of the Research Achievements

本研究において開発した経鼠径リンパ節性リンパ管造影下CTのプロトコールは、汎用性の高いダイナミックリンパ管イメージング法となる可能性が示され、今後の臨床応用を目指す上で重要な基礎データとなると考えられる。今後さらに臨床での有用性、安全性が検証され、安全かつ簡便なリンパ管イメージング法の確立につなげていくことが期待される。

Research Products

• [Presentation] 水溶性ヨード性造影剤を用いたリンパ管造影下CTの有用性に関する検討： リンパ管造影下MRIとの比較 (2021)
  • Author(s): 棚橋 裕吉、庄田 真一、高須 正規、川田 紘資、安藤 知広、永田 翔馬、兵藤 文紀、五島 聡、森 崇、松尾 政之
  • Organizer: 日本医学放射線学会 第168回中部地方会
• [Presentation] Efficacy of Dynamic Contrast-enhanced CT Lymphangiography with Water-soluble Iodine Contrast Media inMicrominipig: Comparison with Dynamic Contrast-enhanced MR Lymphangiography (2021)
  • Author(s): Yukichi Tanahashi, Shinichi Shoda, Masaki Takasu, Hiroshi Kawada, Tomohiro Ando, Shoma Nagata, Fuminori Hyodo, Satoshi Goshima, Takashi Mori, Masayuki Matsuo
  • Organizer: 第80回日本医学放射線学会総会