Project/Area Number |
18K15559
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Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52040:Radiological sciences-related
|
Research Institution | Nara Medical University |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 経カテーテル動脈塞栓術 / 肝細胞癌 / 造影超音波検査 / 動物実験 / ラット肝細胞癌モデル / 造影超音波 / N1S1 / 動注化学療法 / 再分布現象 / パラメトリックイメージング |
Outline of Final Research Achievements |
To compare two different embolic materials, water-in-oil (W/O) emulsion and microspheres in super selective trans-arterial embolization (TAE) using a rat hepatocellular carcinoma model. The tumor vascularity 48 hours after TAE was significantly higher in the Microsphere group (p = 0.034). The overflow of lipiodol into the portal veins surrounding the tumor was seen, whereas microspheres were seen only in the artery. The percentage of necrotic area and complete response ratio in the W/O emulsion group was significantly higher (p = 0.029 and p = 0.041,respectively). Super selective embolization by using W/O emulsion demonstrated stronger antitumor effects with the occlusion of both the tumor feeding artery and the portal vein compared with microspheres which occluded only the arteries.
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Academic Significance and Societal Importance of the Research Achievements |
ビーズTACEは、症例個々において血流の再開通(再分布現象)の程度および時期が異なるため従来の評価方法であるCTでは治療効果判定が困難であり、さらに追加治療のタイミングを判断しにくいという問題点がある。造影超音波検査では、腫瘍内部の細かな血流や血管構築を描出でき、他のモダリティでは得られないリアルタイム性の高い情報が得られる。造影超音波検査を用いれば、再分布現象による血流再開通の有無を判定し効果判定法の開発につながる可能性がある。
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