子宮頸がん放射線治療におけるラディオミクス解析と標的体積縮小モデルの構築

• Project/Area Number: 18K15569
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kitasato University (2020-2022); Japanese Foundation for Cancer Research (2018-2019)
• Principal Investigator: 中野 正寛 北里大学, 医学部, 講師 (50780384)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 子宮頸がん / Radiomics / 適応放射線治療 / 治療効果予測 / 画像特徴量 / 機械学習 / 医学物理学 / 医用画像工学 / 臨床的標的体積 / 形態変化 / ラディオミクス解析 / 治療計画ＣＴ / コーンビームＣＴ / 放射線治療物理学 / 放射線腫瘍学

Outline of Annual Research Achievements

局所進行子宮頸がんは同時化学放射線療法が標準治療である。患者の状態によっては放射線治療が単独で選択されるケースもあるが、いずれにしても放射線治療が果たす役割は大きい。その放射線治療は、リニアック装置を用いた外部照射が先行し、その後に遠隔後充填システム(RALS)を用いた腔内照射が３回から４回程度行われる。治療期間中にprimary CTVである子宮頸部および体部の体積に大幅な縮小が見られる場合が多いが、一方で体積がそれほど変化しない症例もある程度存在する。この子宮頸部および体部の体積が縮小するかしないかが、日々の子宮体部の変形とともにIMRTなどの高精度放射線治療の適応を難しくする要因の一つとなっている。本研究では、子宮頸がん患者の個々の状況にあわせた個別化医療としての放射線治療の提供を目指して、子宮の縮小／非縮小をラディオミクス特徴量を用いて事前に予測する適応放射線治療支援システムの構築を目指している。令和４年度は以下のことを実施した。
（１）機械学習モデル構築の際に、L1正則化、L2正則化など正則化項の違いによって予測精度に変化が見られるか調査した。本研究結果について海外学会にて報告を行った。
（２）ラディオミクス特徴量に加えて、線量分布の特徴量を併用することによって予測精度が向上する可能性があり、本件について検討を開始した。
（３）本研究の手法が子宮頸がん以外の腫瘍にも適用できるか、その可能性について検討を開始した。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

ロジスティック回帰モデルを用いた体積縮小・非縮小の予測モデルの構築についてはある程度の目処が得られた。他の機械学習手法を用
いたモデル構築と、線量分布特徴量を併用することによる予測精度の向上に取り組んでいる。
研究者が所属する機関のコロナ規制により予定通りの進捗や予算執行を実現できず、研究助成の延長を申請した。

Strategy for Future Research Activity

子宮頸がんの放射線治療における子宮の体積縮小に関する機械学習モデルの構築において、ラディオミクス特徴量に加えて線量分布特徴量を併用することで予測精度が向上するか、検討を継続する。正則化項の有無、さらにL1正則化、L2正則化などの正則化項の違いによる予測精度の変化についても、線量分布特徴量を併用することと組み合わせて調査し、精度向上を目指す。本研究の手法が子宮頸がん以外の腫瘍にも適用しうるか検討中である。

Research Products

• [Journal Article] A phase II trial of stereotactic body radiotherapy in 4 fractions for patients with localized prostate cancer (2022)
  • Author(s): Kawakami S.、Tsumura H.、Satoh T.、Tabata K.、Sekiguchi A.、Kainuma T.、Nakano M.、Iwamura M.、Ishiyama H.
  • Journal Title: Radiation Oncology Volume: 17 Issue: 1 Pages: 67-67
  • DOI: 10.1186/s13014-022-02037-y
  • Peer Reviewed / Open Access
• [Journal Article] A Real-Time Four-Dimensional Reconstruction Algorithm of Cine-Magnetic Resonance Imaging (Cine-MRI) Using Deep Learning (2022)
  • Author(s): Tamura Yuto、Demachi Kazuyuki、Igaki Hiroshi、Okamoto Hiroyuki、Nakano Masahiro
  • Journal Title: Cureus Volume: 14 Pages: 1-7
  • DOI: 10.7759/cureus.22826
  • Peer Reviewed / Open Access
• [Journal Article] Dosimetric comparison between three-dimensional conformal radiotherapy followed by electron beam boost and volumetric modulated arc therapy using concomitant boost for the heart and cardiac segments in patients with left-sided breast cancer at risk for radiation-induced cardiac toxicity (2022)
  • Author(s): Murakami Yu、Murakami Yuki、Kamima Tatsuya、Oguchi Masahiko、Abo Natsumi、Takahashi Taro、Kaneko Masahiro、Nakano Masahiro、Matsubayashi Fumiyasu、Harada Arisa、Taguchi Senzo、Hashimoto Takeo、Yoshioka Yasuo
  • Journal Title: Physica Medica Volume: 95 Pages: 126-132
  • DOI: 10.1016/j.ejmp.2022.02.003
  • Peer Reviewed
• [Journal Article] Quality of life score as a prognosticator for pharyngeal cancer patients treated with radiotherapy (2022)
  • Author(s): Ishiyama Hiromichi、Kawakami Shogo、Sekiguchi Akane、Kainuma Takuro、Miyamoto Shunsuke、Yamashita Taku、Nakano Masahiro
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 1-8
  • DOI: 10.1038/s41598-022-06441-y
  • Peer Reviewed / Open Access
• [Journal Article] Dose-Based Radiomic Analysis (Dosiomics) for Intensity Modulated Radiation Therapy in Patients With Prostate Cancer: Correlation Between Planned Dose Distribution and Biochemical Failure (2022)
  • Author(s): Murakami Yu、Soyano Takashi、Kozuka Takuyo、Ushijima Masaru、Koizumi Yuuki、Miyauchi Hikaru、Kaneko Masahiro、Nakano Masahiro、Kamima Tatsuya、Hashimoto Takeo、Yoshioka Yasuo、Oguchi Masahiko
  • Journal Title: International Journal of Radiation Oncology*Biology*Physics Volume: 112 Issue: 1 Pages: 247-259
  • DOI: 10.1016/j.ijrobp.2021.07.1714
  • Peer Reviewed
• [Journal Article] Fast Statistical Iterative Reconstruction for Mega-voltage Computed Tomography (2020)
  • Author(s): S. Ozaki, A. Haga, E. Chao, C. Maurer, K. Nawa, T. Ohta, T. Nakamoto, Y. Nozawa, T. Magome, M. Nakano, K. Nakagawa
  • Journal Title: The Journal of Medical Investigation Volume: 67 Issue: 1.2 Pages: 30-39
  • DOI: 10.2152/jmi.67.30
  • NAID: 130007839921
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fast Iterative Reconstruction for Mega-voltage Computed Tomograpy (2020)
  • Author(s): Sho Ozaki, Akihiro Haga, Edward Chao, Calvin Maurer, Kanabu Nawa, Takeshi Ohta, Takahiro Nakamoto, Yuki Nozawa, Taiki Magome, Masahiro Nakano, Keiichi Nakagawa
  • Journal Title: The Journal of Medical Investigation Volume: 67 Pages: 30-39
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of organ-at-risk dose reduction with jaw tracking technique in flattening filter-free beams in lung stereotactic body radiation therapy (2019)
  • Author(s): Murakami Yu、Magome Taiki、Matsubayashi Fumiyasu、Takahashi Ryo、Arima Masato、Kamima Tatsuya、Nakano Masahiro、Sato Tomoharu、Yoshioka Yasuo、Oguchi Masahiko
  • Journal Title: Physica Medica Volume: 61 Pages: 70-76
  • DOI: 10.1016/j.ejmp.2019.04.018
  • Peer Reviewed
• [Journal Article] Possibility of chest wall dose reduction using volumetric-modulated arc therapy (VMAT) in radiation-induced rib fracture cases: comparison with stereotactic body radiation therapy (SBRT) (2018)
  • Author(s): Murakami Yu、Nakano Masahiro、Yoshida Masahiro、Hirashima Hideaki、Nakamura Fumiya、Fukunaga Junichi、Hirose Taka-aki、Yoshioka Yasuo、Oguchi Masahiko、Hirata Hideki
  • Journal Title: Journal of Radiation Research Volume: 59 Issue: 3 Pages: 327-332
  • DOI: 10.1093/jrr/rry012
  • NAID: 120006863526
  • Peer Reviewed / Open Access
• [Journal Article] Cone Beam Computed Tomography Image Quality Improvement Using a Deep Convolutional Neural Network (2018)
  • Author(s): Kida Satoshi、Nakamoto Takahiro、Nakano Masahiro、Nawa Kanabu、Haga Akihiro、Kotoku Jun'ichi、Yamashita Hideomi、Nakagawa Keiichi
  • Journal Title: Cureus Volume: - Pages: 1-15
  • DOI: 10.7759/cureus.2548
  • Peer Reviewed / Open Access
• [Presentation] 前立腺癌定位放射線治療における腫瘍内線量増加方法に関する多施設共同プランニングスタディ (2023)
  • Author(s): 藤井恭平、稲葉浩二、竹森望弘、小田切一将、菅原章友、富田夏夫、眞鍋良彦、岡本裕之、中野正寛、石山博條
  • Organizer: 第36回高精度放射線外部照射部会学術大会
• [Presentation] Feasibility study of lost regions generation for limited field of view CBCT images using Diffusion Models (2023)
  • Author(s): Kohei Yamamoto, Ryutaro Yamashita, Yuichi Tanaka, Masahiro Nakano, Hiromichi Ishiyama, Tomoyuki Hasegawa, Masatoshi Hashimoto
  • Organizer: 第125回日本医学物理学会学術大会
• [Presentation] 大面積Cr添加Al2O3セラミック板の2次元線量応答特性 (2023)
  • Author(s): 中村祥希、村石浩、渡邉祐介、石塚彩奈、江口昴、稲田龍司、中野正寛、石山博條
  • Organizer: 第70回日本応用物理学会春季学術講演会
• [Presentation] 頭頸部放射線治療における正常臓器の自動輪郭描出システムの開発と臨床導入 (2022)
  • Author(s): 中野正寛、山本浩平、橋本成世、川上正悟、藤井恭平、石山博條
  • Organizer: 2022年度神奈川県放射線医会総会・第62回例会
• [Presentation] 円柱形プラスチックシンチレータとCCDカメラを用いた3次元線量分布再構成システムの開発 (2022)
  • Author(s): 田中悠一, 石上稔, 松井光, 山下隆太郎, 山本浩平, 村上幸, 宮内輝, 中野正寛, 長谷川智之, 橋本成世
  • Organizer: 第124回日本医学物理学会学術大会
• [Presentation] 多断面平均法を用いた頭頸部CT画像における多臓器セグメンテーションの精度向上 (2022)
  • Author(s): 山本浩平、中野正寛、石山博條、田中悠一、長谷川智之、橋本成世
  • Organizer: 第124回日本医学物理学会学術大会
• [Presentation] Auto Segmentation Model for Head and Neck Cancer Patients Using U-Net with Convolutional Block Attention Modules (2022)
  • Author(s): K Yamamoto, R Nakagami, M Nakano, H Ishiyama, Y Tanaka, T Hasegawa, M Hashimoto
  • Organizer: AAPM 64th Annual Meeting and Exhibition
• [Presentation] Radiomic and dosiomic prediction of biochemical failure after Iodine-125 prostate brachytherapy (2022)
  • Author(s): Masahiro Nakano, Shogo Kawakami, Takeo Katakura, Akane Sekiguchi, Takuro Kainuma, Hideyasu Tsumura, Masatoshi Hashimoto, Tomoyuki Hasegawa, Yuichi Tanaka, Yu Murakami, Hiromichi Ishiyama
  • Organizer: ESTRO 2022
  • Int'l Joint Research
• [Presentation] Dosimetric Comparison Between 3D Conformal Radiation Therapy Plus Electron Boost and Simultaneous Integrated Boost Volumetric Modulated Arc Therapy for Left-Sided Breast Cancer Patients With a Potential Risk of Radiation-Induced Cardiac Toxicity (2021)
  • Author(s): Yu Murakami, Yuki Murakami, Tatsuya Kamima, Natsumi Abo, Taro Takahashi, Masahiro Kaneko, Masahiro Nakano, Fumiyasu Matsubayashi, Arisa Harada, Senzo Taguchi, Takeo Hashimoto, Masahiko Oguchi, Yasuo Yoshioka
  • Organizer: 2021 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] Development of Novel Image Processing System Using Super-Resolution to Reduce Cone-Beam CT Imaging Dose in Radiation Therapy (2021)
  • Author(s): Hikaru Miyauchi, Yuichi Tanaka, Kentaro Takahashi, Masahiro Nakano, Tomoyuki Hasegawa, Masatoshi Hashimoto, Takeo Hashimoto, Masahiko Oguchi, Yasuo Yoshioka
  • Organizer: 2021 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] Can Dosiomics Features Be Relevant Predictive Factors for Biochemical Recurrence After Radiotherapy in Prostate Cancer Patients? (2021)
  • Author(s): Murakami Yu、Soyano Takashi、Kozuka Takuyo、Ushijima Masaru、Koizumi Yuuki、Miyauchi Hikaru、Kaneko Masahiro、Nakano Masahiro、Kamima Tatsuya、Hashimoto Takeo、Oguchi Masahiko, Yoshioka Yasuo
  • Organizer: 2021 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] Prediction of Late Xerostomia after Radiotherapy by Integrating Dosiomics and Conventional Predictive Factors in Patients With Oropharyngeal Cancer (2021)
  • Author(s): Arisa Ikarashi, Yu Murakami, Takashi Toshiyasu, Minoru Yoshioka, Tatsuya Kamima, Kenji Tokumasu, Masahiro Nakano, Takeo Hashimoto, Masahiko Oguchi, Yasuo Yoshioka
  • Organizer: 2021 ASTRO Annual Meeting
  • Int'l Joint Research
• [Presentation] 3次元線量分布と機器動作の同時検証に基づいたIMRT検証システムの開発 (2021)
  • Author(s): 田中 悠一, 宮内 輝, 髙橋 健太郎, 石上 稔, 中野 正寛, 長谷川 智之, 橋本 成世
  • Organizer: 第34回高精度放射線外部照射部会学術大会
• [Presentation] 深層学習を用いたCT撮影時における被ばく線量低減システムの開発 (2021)
  • Author(s): 宮内 輝, 田中 悠一, 高橋 健太郎, 中野 正寛, 長谷川 智之, 橋本 成世
  • Organizer: 第34回高精度放射線外部照射部会学術大会
• [Presentation] IMRT verification by three-dimensional dose distribution measurements using plastic scintillator and CCD camera (2021)
  • Author(s): Yuichi Tanaka, Minoru Ishigami, Hikaru Miyauchi, Kentaro Takahashi, Masahiro Nakano, Tomoyuki Hasegawa, Masatoshi Hashimoto
  • Organizer: 第121回日本医学物理学会学術大会
• [Presentation] Prediction of Uterus Volume Shrinkage for Cervical Cancer Patients During Radiotherapy Using Machine-Learning Approach with Treatment Planning-CT Radiomic Features (2020)
  • Author(s): Masahiro Nakano, Takahiro Nakamoto, Yasuko Kumai, Yuki Koizumi, Minako Sumi, Kanabu Nawa, Toshikazu Imae, Yasuo Yoshioka, Masahiko Oguchi
  • Organizer: Joint AAPM|COMP Meeting, Virtual, July 2020
  • Int'l Joint Research
• [Presentation] Delivery quality assurance system based on simultaneous verification of three-dimensional dose distribution and mechanical motion (2020)
  • Author(s): Yuichi Tanaka, Minoru Ishigami, Hikaru Miyauchi, Kentaro Takahashi, Masahiro Nakano, Tomoyuki Hasegawa, Masatoshi Hashimoto
  • Organizer: Joint AAPM|COMP Meeting, Virtual, July 2020
  • Int'l Joint Research
• [Presentation] Image Processing System by Super-Resolution Using Deep Learning Leading to Exposure Dose Reduction (2020)
  • Author(s): Hikaru Miyauchi, Yuichi Tanaka, Kentaro Takahashi, Masahiro Nakano, Tomoyuki Hasegawa, Masatoshi Hashimoto
  • Organizer: Joint AAPM|COMP Meeting, Virtual, July 2020
  • Int'l Joint Research
• [Presentation] Realtime 3D movie reconstruction algorithm using MR-linac by deep learning (2020)
  • Author(s): Yuuto Tamura, Kazuyuki Demachi, Ryota Kitsunai, Chhatkuli Ritu Bhusal, Masahiro Nakano, Kanabu Nawa, Keiichi Nakagawa
  • Organizer: 第119回日本医学物理学会学術大会
• [Presentation] Pseudo-CBCT Image Prediction of Head and Neck Cancer Patient Using Principal Component Vector Fields of Early Treatment Fractions (2019)
  • Author(s): Masahiro Nakano, Toshikazu Imae, Takahiro Nakamoto, Akihiro Haga, Kanabu Nawa, Yukihiro Nomura, Ritu Chhatkuli, Kazuyuki Demachi, Wataru Takahashi, Kentaro Yamamoto, Keiichi Nakagawa, Masatoshi Hashimoto, Yasuo Yoshioka, Masahiko Oguchi
  • Organizer: American Association of Physicists in Medicine 61st Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Development of a Novel Delivery Quality Assurance System Based On Simultaneous Verification of Dose Distribution and MLC Movement Using Plastic Scintillator and CCD Camera (2019)
  • Author(s): Yuichi Tanaka, Minoru Ishigami, Tsuyoshi Terazaki, Masahiro Nakano, Hikaru Miyauchi, Tomoyuki Hasegawa, Masatoshi Hashimoto
  • Organizer: American Association of Physicists in Medicine 61st Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Pseudo-CBCT image prediction of head and neck cancer patient using principal component vector fields of early treatment fractions (2019)
  • Author(s): Masahiro Nakano, Toshikazu Imae, Takahiro Nakamoto, Kanabu Nawa, Akihiro Haga, Wataru Takahashi, Keiichi Nakagawa, Masatoshi Hashimoto, Yasuo Yoshioka and Masahiko Oguchi
  • Organizer: 第117回日本医学物理学会学術大会
• [Presentation] A study of real-time 3D movie reconstruction for intensity modulated radiation therapy using the MRI (2019)
  • Author(s): Ryota Kitsunai, Kazuyuki Demachi, Kenichiro Kuwabara, Kanabu Nawa, Keiichi Nakagawa, Masahiro Nakano
  • Organizer: 第117回日本医学物理学会学術大会
• [Presentation] Effect of prostatic calcification on radiomic features extracted from computed tomography (CT) (2019)
  • Author(s): Yu Murakami, Taiki Magome, Masahiro Nakano, Tomoharu Sato, Yasuo Yoshioka, Masahiko Oguchi
  • Organizer: The 52 nd Annual Meeting of the Taiwan Society of Radiological Technologists (TWSRT) and the International Conference of Medical Imaging
  • Int'l Joint Research
• [Presentation] VMATを用いた肺定位放射線治療におけるITV内のCT値の割り当てがGTV線量に及ぼす影響 (2019)
  • Author(s): 村上悠、上間達也、松林史泰、浅利崇生、鈴木涼子、中野正寛、吉岡靖生、小口正彦
  • Organizer: 第32回日本放射線腫瘍学会高精度放射線外部照射部会学術大会
• [Presentation] Patient Setup System Using a Virtual X-Ray Image (2018)
  • Author(s): Masatoshi Hashimoto, Masahiro Nakano, Akihiro Haga, Kanabu Nawa
  • Organizer: American Association of Physicists in Medicine 60th Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Field-Of-View Expansion of Megavoltage CT Based On Iterative Reconstruction Algorithm Using Information of Treatment Planning KV-CT (2018)
  • Author(s): Yuki Watanabe, Taiki Magome, Akihiro Haga, Kanabu Nawa, Masahiro Nakano, Yukihiro Nomura, Shouhei Hanaoka, Keiichi Nakagawa, D Zuro, C Han, J Wong, Susanta Hui
  • Organizer: American Association of Physicists in Medicine 60th Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] Potential of Jaw Tracking Technique in Flattening Filter-Free Beam for Lung Stereotactic Body Radiation Therapy (2018)
  • Author(s): Yu Murakami, Fumiyasu Matsubayashi, Taiki Magome, Ryo Takahashi, Masato Arima, Tatsuya Kamima, Masahiro Nakano, Tomoharu Sato, Yasuo Yoshioka, Masahiko Oguchi
  • Organizer: American Association of Physicists in Medicine 60th Annual Meeting and Exhibition
  • Int'l Joint Research
• [Presentation] CBCT image quality improvement using a deep convolution neural network (2018)
  • Author(s): Satoshi Kida, Takahiro Nakamoto, Masahiro Nakano, Kanabu Nawa, Akihiro Haga, Jun'ichi Kotoku, Hideomi Yamashita, Keiichi Nakagawa
  • Organizer: 第115回日本医学物理学会学術大会
• [Presentation] Field-of-view expansion of megavoltage CT based on iterative reconstruction algorithm using prior information (2018)
  • Author(s): Yuki Watanabe, Taiki Magome, Akihiro Haga, Kanabu Nawa, Masahiro Nakano, Yukihiro Nomura, Shohei Hanaoka and Keiichi Nakagawa
  • Organizer: 第115回日本医学物理学会学術大会
• [Presentation] 治療計画用kVCTを事前情報に用いた逐次近似再構成法に基づくMVCT画像の有効視野拡大方法の開発 (2018)
  • Author(s): 渡辺悠紀、馬込大貴、芳賀昭弘、名和要武、中野正寛、野村行弘、花岡昇平、中川恵一
  • Organizer: 第116回日本医学物理学会学術大会
• [Presentation] Reconstruction of Tumor Behaviors Movie by Optical Flow and Principal Component Analysis (2018)
  • Author(s): 唐 茂芯、出町和之、Chhatkuli Ritu Bhusal、中川恵一、中野正寛、名和要武
  • Organizer: 第116回日本医学物理学会学術大会