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Development of radiation therapy treatment planning techniques for prostate cancer with non-invasive urethra visualization method using MRI

Research Project

Project/Area Number 18K15577
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionHokkaido University

Principal Investigator

Yoshimura Takaaki  北海道大学, 保健科学研究院, 助教 (70807742)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsMRI / 放射線治療計画 / 前立腺癌 / 尿道 / スポットスキャニング陽子線治療 / TCP/NTCP / 動体追跡陽子線治療 / 治療プロセス / 医学物理 / NTCPモデル
Outline of Final Research Achievements

Urethra-sparing radiation therapy for localized prostate cancer can reduce the risk of radiation-induced genitourinary toxicity by intentionally underdosing the periurethral transitional zone. We proposed a method using post-urination high resolution T2-weighted 3.0 T MRI (PU-MRI) in urethra-sparing treatment planning. Our results demonstrated that the inter-operator prostatic urinary tract Region of Interest (ROI) matched with a high accuracy, not only in CT with a urethral catheter, but also in PU-MRI. Thus, PU-MRI is useful in identifying the urethra non-invasively, without using a urethral catheter. Moreover, compared with the conventional clinically applied plans, urethra-sparing proton therapy have potential clinical advantages and may reduce the risk of genitourinary toxicities, while maintaining the same tumor control probability and normal tissue complication probability in the rectum and bladder. And there were expectations for the promotion of future research.

Academic Significance and Societal Importance of the Research Achievements

本研究では、トイレで排尿直後にMRIを撮影することによって、従来の侵襲的に尿道カテーテルを挿入することによる尿道同定法における課題であった感染リスクや患者の心理的負担を取り除くことができる非侵襲的な尿道同定法を提案した。さらに、本研究で提案した尿道同定法で同定された尿道に対する線量を下げた治療計画をシミュレーションすることにより、現在臨床で用いられている治療計画と同等の腫瘍制御確率、直腸と膀胱の正常組織障害発生確率を維持しながら、尿道の障害発生確率のみを有意に低減できることを示した。本研究の成果は、患者の負担が少ない放射線治療法として普及することが期待され、社会的意義あるものであったと考える。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (13 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Journal Article] Visualizing the urethra by magnetic resonance imaging without usage of a catheter for radiotherapy of prostate cancer2021

    • Author(s)
      Yoshimura Takaaki、Nishioka Kentaro、Hashimoto Takayuki、Fujiwara Taro、Ishizaka Kinya、Sugimori Hiroyuki、Kogame Shoki、Seki Kazuya、Tamura Hiroshi、Tanaka Sodai、Matsuo Yuto、Dekura Yasuhiro、Kato Fumi、Aoyama Hidefumi、Shimizu Shinichi
    • Journal Title

      Physics and Imaging in Radiation Oncology

      Volume: 18 Pages: 1-4

    • DOI

      10.1016/j.phro.2021.03.002

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A treatment planning study of urethra-sparing intensity-modulated proton therapy for localized prostate cancer2021

    • Author(s)
      Yoshimura Takaaki、Nishioka Kentaro、Hashimoto Takayuki、Seki Kazuya、Kogame Shouki、Tanaka Sodai、Kanehira Takahiro、Tamura Masaya、Takao Seishin、Matsuura Taeko、Kobashi Keiji、Kato Fumi、Aoyama Hidefumi、Shimizu Shinichi
    • Journal Title

      Physics and Imaging in Radiation Oncology

      Volume: 20 Pages: 23-29

    • DOI

      10.1016/j.phro.2021.09.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Are simple verbal instructions sufficient to ensure that bladder volume does not deteriorate prostate position reproducibility during spot scanning proton therapy?2021

    • Author(s)
      Nishioka Kentaro、Gotoh Kento、Hashimoto Takayuki、Abe Takashige、Osawa Takahiro、Matsumoto Ryuji、Yokota Isao、Katoh Norio、Kinoshita Rumiko、Yasuda Koichi、Yakabe Toshiaki、Yoshimura Takaaki、Takao Seishin、Shinohara Nobuo、Aoyama Hidefumi、Shimizu Shinichi、Shirato Hiroki
    • Journal Title

      BJR|Open

      Volume: 3 Issue: 1

    • DOI

      10.1259/bjro.20210064

    • NAID

      120007171672

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative analysis of treatments using real‐time image gated spot‐scanning with synchrotron‐based proton beam therapy system log data2020

    • Author(s)
      Yoshimura Takaaki、Shimizu Shinichi、Hashimoto Takayuki、Nishioka Kentaro、Katoh Norio、Taguchi Hiroshi、Yasuda Koichi、Matsuura Taeko、Takao Seishin、Tamura Masaya、Tanaka Sodai、Ito Yoichi M.、Matsuo Yuto、Tamura Hiroshi、Horita Kenji、Umegaki Kikuo、Shirato Hiroki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 12 Pages: 10-19

    • DOI

      10.1002/acm2.13029

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The urethral position may shift due to urethral catheter placement in the treatment planning for prostate radiation therapy2019

    • Author(s)
      Dekura Yasuhiro、Nishioka Kentaro、Hashimoto Takayuki、Miyamoto Naoki、Suzuki Ryusuke、Yoshimura Takaaki、Matsumoto Ryuji、Osawa Takahiro、Abe Takashige、Ito Yoichi M.、Shinohara Nobuo、Shirato Hiroki、Shimizu Shinichi
    • Journal Title

      Radiation Oncology

      Volume: 14 Issue: 1 Pages: 226-226

    • DOI

      10.1186/s13014-019-1424-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of treatment process time for real‐time‐image gated‐spot‐scanning proton‐beam therapy (RGPT) system2019

    • Author(s)
      Yoshimura Takaaki、Shimizu Shinichi、Hashimoto Takayuki、Nishioka Kentaro、Katoh Norio、Inoue Tetsuya、Taguchi Hiroshi、Yasuda Koichi、Matsuura Taeko、Takao Seishin、Tamura Masaya、Ito Yoichi M.、Matsuo Yuto、Tamura Hiroshi、Horita Kenji、Umegaki Kikuo、Shirato Hiroki
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 21 Issue: 2 Pages: 38-49

    • DOI

      10.1002/acm2.12804

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The Impact of Daily Urinary Volume Variations and Prostate Volume on Prostate Position During Radiotherapy.2021

    • Author(s)
      Nishioka K, Hashimoto T, Yokota I, Katoh N, Kinoshita R, Yasuda K, Takao S, Yoshimura T, Aoyama T, Shimizu S
    • Organizer
      The 80th Annual meeting of the Japan Radiological Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dosimetric impact of the adaptive planning frequency for IMPT of prostate cancer using daily in-room CT images2021

    • Author(s)
      Tamura H, Maeda Y, Nishioka K, Yoshimura T, Hashimoto T, Shimizu S, Sasaki M, Yamamoto K, Tamamura H, Aoyama H, Shirato H
    • Organizer
      The 9th Korea-Japan Joint Meeting on Medical Physics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Urethra-sparing intensity modulated proton therapy for localized prostate cancer woith non-invassive urethra visualization method2021

    • Author(s)
      Yoshimura T
    • Organizer
      The 5th FHS International Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Preliminary study of methods for estimating Gleason score using deep learning2021

    • Author(s)
      Manabe K, Yoshimura T, Yamada T, Asammi Y, Sugimori H
    • Organizer
      The 5th FHS International Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Deep learning を用いた前立腺がん検出の精度向上に関する基礎的検討2021

    • Author(s)
      Manabe K, Yoshimura T, Yamada T, Asami Y, Sugimori H
    • Organizer
      第49回日本放射線技術学会秋季学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Evaluation of visualizing the prostatic urinary tract in MRI with a super resolution deep learning model for urethra sparing radiotherapy2021

    • Author(s)
      Yoshimura T, Nishioka K, Hashimoto T, Kogame S, Seki K, Sugimori H, Yamashina H, Kato F, Aoyama H, Kudo K, Shimizu S
    • Organizer
      The 63rd Annual meeting for American Society for Radiation Oncology (ASTRO)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Urethra Sparing Intensity Modulated Proton Therapy for Localized Prostate Cancer: A simulation study2021

    • Author(s)
      Seki K, Yoshimura T, Nishioka K, Hashimoto T, Kogame S, Tanaka S, Kanehira T, Tamura M, Takao S, Matsuura T, Kobashi K, Kato F, Aoyama H, Shimizu S
    • Organizer
      日本放射線腫瘍学会第34回学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dose Volume Statistics of daily adaptive IMPT for prostate cancer using daily in-room CT images2021

    • Author(s)
      Tamura H, Maeda Y, Nishioka K, Kobashi K, Yoshimrua T, Hashimoto T, Shimizu S, Sasaki M, yamamoto K, Tamamura H, Aoyama H, Shirato H
    • Organizer
      Dose Volume Statistics of daily adaptive IMPT for prostate cancer using daily in-room CT images. 日本放射線腫瘍学会第34回学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Visualizing the prostatic urinary tract with post-urination MRI: Inter-operator contouring accuracy2020

    • Author(s)
      Yoshimura T, Nishioka K, Hashimoto T, Fujiwara T, Ishizaka K, Sugimori H, Kogame S, Seki K, Tamura H, Tanaka S, Matsuo Y, Dekura Y, Kato F, Aoyama H, Shimizu S
    • Organizer
      第33回日本放射線腫瘍学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Quantitative analysis of treatment process flow using real-time-image gated-spot-scanning proton-beam delivery log system2019

    • Author(s)
      Yoshimura T, Tanaka S, Shimizu S, Hashimoto T, Katoh N, Matsuura T, Takao S, Matsuo Y, Tamura H, Shirato H
    • Organizer
      58th Annual Meeting for the Particle Therapy Co-operative Group (PTCOG)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 北海道大学病院における強度変調陽子線治療(IMPT)の経験2018

    • Author(s)
      Yoshimura T, Shimizu S, Hashimoto T, NIshioka K, Katoh N, Yasuda K, Matsuura T, Takao S, Tamura M, Matsuo Y, Horita K, Nannkumo J, Tamura H, Umegaki K, Shirato H
    • Organizer
      第15回日本粒子線治療臨床研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] Analysis of Beam Delivery Times and Dose Rates for the Treatment of Mobile Tumors Using Real Time Image Gated Spot-Scanning Proton Beam Therapy2018

    • Author(s)
      Shimizu S, Yoshimura T, Katoh N, Inoue T, Hashimoto T, Nishioka K, Takao S, Matsuura T, Miyamoto N, Ito M. Y, Umegaki K, Shirato H
    • Organizer
      The 60th Annual meeting for American Society for Radiation Oncology (ASTRO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Big Data Analysis of Treatment Process Time for the Real-time-image Gated-spot-scanning Proton-beam Therapy (RGPT) System2018

    • Author(s)
      Yoshimura T, Shimizu S, Hashimoto T, Katoh N, Inoue T, Nishioka K, Matsuura T, Takao S, Tamumra M, Tamura H, Horita K, Umegaki K, Shirato H
    • Organizer
      The 60th Annual meeting for American Society for Radiation Oncology (ASTRO)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2023-01-30  

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