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Exploring he dysfunction of glymphatic system in glaucoma using a novel MR imaging PADRE

Research Project

Project/Area Number 18K15580
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionTohoku University

Principal Investigator

Tatewaki yasuko  東北大学, 加齢医学研究所, 助教 (40722202)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords緑内障 / 認知症 / glymphatic system / アミロイドβ / 海馬 / 血管周囲腔 / MRI / アルツハイマー病 / 認知心理検査
Outline of Final Research Achievements

1. There was no difference in hippocampal volume, which is related to cognitive function, between glaucoma and normal groups. On the other hand, a significant correlation was found between equivalent spherical power, a measure of myopia, and hippocampal volume especially in the glaucoma group.
2. We have developed new MRI images which enable to visualize of amyloid-β, and the image-processing program has been in domestic patent-pending and PCT filed. We have collected the special MRI images of approximately 200 glaucoma and normal subjects, and data analysis is currently underway.
3. There was no significant difference in parameters reflecting perivascular space volume between glaucoma and healthy groups. However, the reproducibility and reliability of the parameter we used in this analysis could not be established, and we create our own AI program for automatic measurement of the perivascular space for the sake of reanalyzing the data.

Academic Significance and Societal Importance of the Research Achievements

本研究は画像というアプローチから緑内障と認知症の共通病態の検証を行った。研究期間中、コロナ禍のためにデータ収集や解析が予定通り進まず、解析が可能だった範囲においては、緑内障と認知症を強く結びつける知見は得られなかった。
一方で、本検討に関連して、MRIでアミロイドβを可視化する新規画像を開発するという大きな成果を得た。非侵襲かつ廉価な本技術が実用化することで、本研究だけではなく、認知症臨床や各種認知症研究、治験などにおいても大きなブレークスルーとなることが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (44 results)

All 2022 2021 2020 2019 2018

All Journal Article (15 results) (of which Peer Reviewed: 13 results,  Open Access: 10 results) Presentation (27 results) (of which Int'l Joint Research: 7 results,  Invited: 3 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Alzheimer’s Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet.2021

    • Author(s)
      Takeishi J, Tatewaki Y, Nakase T, Takano Y, Tomita N, Yamamoto S, Mutoh T, Taki Y.
    • Journal Title

      Int J Mol Sci.

      Volume: 22 Issue: 22 Pages: 12310-12310

    • DOI

      10.3390/ijms222212310

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 認知症の一次予防、二次予防を目指した最新MRI画像解析-AIとモルフォロジー解析の活用2021

    • Author(s)
      舘脇康子, 瀧靖之
    • Journal Title

      Clinical Neuroscience

      Volume: 39 Pages: 1251-1253

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Defining the Optimal Method for Measuring Metabolic Tumor Volume on Preoperative 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography as a Prognostic Predictor in Patients With Pancreatic Ductal Adenocarcinoma2020

    • Author(s)
      Tatewaki Y, Terao MC, Ariake K, Saito R, Mutoh T, Shimomura H, Motoi F, Mizuma M, Odagiri H, Unno M, Taki Y
    • Journal Title

      Front Oncol.

      Volume: 11 Pages: 646141-646141

    • DOI

      10.3389/fonc.2021.646141

    • Related Report
      2021 Annual Research Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alzheimer’s Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?2020

    • Author(s)
      Miyazawa Keishi、Fukunaga Hisanori、Tatewaki Yasuko、Takano Yumi、Yamamoto Shuzo、Mutoh Tatsushi、Taki Yasuyuki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 16 Pages: 5783-5783

    • DOI

      10.3390/ijms21165783

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voxel-Based Morphometry Reveals a Correlation Between Bone Mineral Density Loss and Reduced Cortical Gray Matter Volume in Alzheimer’s Disease2020

    • Author(s)
      Takano Yumi、Tatewaki Yasuko、Mutoh Tatsushi、Morota Naoya、Matsudaira Izumi、Thyreau Benjamin、Nagasaka Tatsuo、Odagiri Hayato、Yamamoto Shuzo、Arai Hiroyuki、Taki Yasuyuki
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 12 Pages: 1-8

    • DOI

      10.3389/fnagi.2020.00178

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoperfusion in the posterior cingulate cortex is associated with lower bone mass density in elderly women with osteopenia and Alzheimer's disease.2020

    • Author(s)
      Takano Y, Mutoh T, Tatewaki Y, Seki T, Yamamoto S, Odagiri H, Arai H, Taki Y.
    • Journal Title

      Clin Exp Pharmacol Physiol. 2020 Mar;47(3):365-371

      Volume: 47(3) Issue: 3 Pages: 365-371

    • DOI

      10.1111/1440-1681.13217

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images.2019

    • Author(s)
      Tatewaki Y, Mutoh T, Omodaka K, Thyreau B, Matsudaira I, Furukawa H, Yamada K, Kunitoki K, Kawashima R, Nakazawa T, Taki Y.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 15148-15148

    • DOI

      10.1038/s41598-019-51611-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical Utility of a Semiquantitative Method Using Lumbar Radiography as a Screening Tool for Osteoporosis in Elderly Subjects.2019

    • Author(s)
      Kunitoki K, Mutoh T, Tatewaki Y, Takano Y, Yamamoto S, Shimomura H, Nakagawa M, Arai H, Taki Y.
    • Journal Title

      Med Sci Monit

      Volume: 25 Pages: 6928-6934

    • DOI

      10.12659/msm.917035

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assessment of Gait Symmetry in Elderly Women with Low Bone Mineral Density Using a Portable Trunk Accelerometer: A Pilot Study2019

    • Author(s)
      Takano Yumi、Mutoh Tatsushi、Tatewaki Yasuko、Yamamoto Shuzo、Shimomura Hideo、Nakagawa Manabu、Arai Hiroyuki、Taki Yasuyuki
    • Journal Title

      Medical Science Monitor

      Volume: 25 Pages: 6669-6674

    • DOI

      10.12659/msm.916763

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-invasive three-dimensional power Doppler imaging for the assessment of acute cerebral blood flow alteration in a mouse model of subarachnoid haemorrhage.2019

    • Author(s)
      Yamamoto S, Mutoh T, Sasaki K, Mutoh T, Tatewaki Y, Taki Y.
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 46 Pages: 99-102

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 特集 画像診断医のための認知症画像診断 正常加齢の画像所見2018

    • Author(s)
      舘脇康子, 瀧靖之
    • Journal Title

      画像診断

      Volume: 38 Issue: 9 Pages: 866-878

    • DOI

      10.15105/GZ.0000000613

    • ISSN
      0285-0524, 2432-1281
    • Year and Date
      2018-07-25
    • Related Report
      2018 Research-status Report
  • [Journal Article] Quantitative MRI evaluation of glaucomatous changes in the visual pathway.2018

    • Author(s)
      Fukuda M, Omodaka K, Tatewaki Y, Himori N, Matsudaira I, Nishiguchi KM, Murata T, Taki Y, Nakazawa T.
    • Journal Title

      PLoS One

      Volume: 13 Issue: 7 Pages: 0-0

    • DOI

      10.1371/journal.pone.0197027

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preceding functional tooth loss delays recovery from acute cerebral hypoxia and locomotor hypoactivity after murine subarachnoid haemorrhage.2018

    • Author(s)
      Mutoh T, Sasaki K, Tatewaki Y, Kunitoki K, Takano Y, Taki Y
    • Journal Title

      Clin Exp Pharmacol Physiol

      Volume: 45 Pages: 344-348

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of non-convulsive status epilepticus with bradylalia using arterial spin-labeling magnetic resonance imaging.2018

    • Author(s)
      Yamamoto S, Mutoh T, Tatewaki Y, Tsurutani H, Watabe N, Saito H, Yasui N, Taki Y
    • Journal Title

      Acute Med Surg

      Volume: 23 Issue: 1 Pages: 73-77

    • DOI

      10.1002/ams2.369

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolated Fornix Infarction with Damage to the Limbic System as a Cause of Persistent Amnesia: A Case Report.2018

    • Author(s)
      Takano Y, Tatewaki Y, Mutoh T, Ohara Y, Yamamoto S, Taki Y.
    • Journal Title

      Am J Case Rep

      Volume: 19 Pages: 1382-1385

    • DOI

      10.12659/ajcr.912508

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Impact of social activity on depressive symptoms and brain regional gray matter.2021

    • Author(s)
      Yingxu Liu, Benjamin Thyreau, Yasuko Tatewaki, Ye Zhang, Izumi Matsudaira, Yuji Takano, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Toshiharu Ninomiya, Yasuyuki Taki.
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アルツハイマー病の進行に関与する便秘の影響についての検討.2021

    • Author(s)
      中瀬泰然, 舘脇康子, Thyreau Benjamin, 武藤達士, 冨田尚希, 山本修三, 髙野由美, 村中美千帆, 瀧靖之.
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 認知症病態に関わる心房細動の影響についての検討.2021

    • Author(s)
      中瀬泰然, 竹石潤平, 舘脇康子, Thyreau Benjamin, 武藤達士, 冨田尚希, 山本修三, 髙野由美, 村中美千帆, 瀧靖之.
    • Organizer
      第40回日本認知症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] コロナワクチン接種後に多臓器の障害が見られた高齢認知症の1例.2021

    • Author(s)
      村中美千帆, 冨田尚希, 中瀬泰然, 髙野由美, 山本修三, 舘脇康子, 武藤達士, 瀧靖之.
    • Organizer
      第32回日本老年医学会東北地方会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Altruistic Social Activity Impacts on Depressive Symptoms and Brain Regional Gray Matter Volume: Voxel-Based Morphometry Analysis from 8695 Old Adults.2021

    • Author(s)
      LIU Y, Zhang Y, Tatewaki Y, Matsudaira I, Takano Y, Hirabayashi N, Furuta Y, Hata J, Ninomiya T, Taki Y.
    • Organizer
      第16回生命医科学研究所ネットワーク国際シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] 位相差強調画像化法におけるアミロイド斑評価の精度・再現性の向上:モルフォロジー演算の応用2021

    • Author(s)
      荒井晃、舘脇康子、米田哲也、武藤達士、Benjamin Thyreau、石木愛子、永坂竜男、明石敏明、荒井啓行、瀧靖之
    • Organizer
      第80回日本医学放射線学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Voxel-based morphometry reveals cerebellar brain volume differences associated with subclinical ADHD.2021

    • Author(s)
      Asaoka H, TatewakiY, Matsudaira I, Takeushi H, Kawashima R, Taki Y.
    • Organizer
      The Organization for Human Brain Mapping annual meeting The 27th
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Voxel-Based Morphometry Reveals That Different Subtypes of Bully Victimization Have Different Effects on the Brain.2021

    • Author(s)
      Fujiwara S, Matsudaira I, Tatewaki Y, Takeuchi H, Kawashima R, Taki Y.
    • Organizer
      The American Academy of Child & Adolescent Psychiatry annual meeting The 68th
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catheter Ablation Improves Quasar-Arterial Spin Labeling Based Regional Brain Perfusion in the Posterior Cingulate Cortex and Auditory-verbal Memory Function in Elderly Patients With Atrial Fibrillation2020

    • Author(s)
      Tatewaki Y, Mutoh T, Sato H, Enoki R, Kobayashi A, Muranaka M, yagi T
    • Organizer
      American Heart Association 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 心房細動のアブレーション治療による認知機能改善効果と局所脳血流の変化に関する検討2020

    • Author(s)
      榎亮、舘脇康子、武藤達士、佐藤弘和、高野由美、山本修三、小林亜希子、八木哲夫、瀧靖之
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 非痙攣性てんかん重積の早期診断に MRIASL 灌流画像が有用であった症例2020

    • Author(s)
      山本修三、武藤達士、髙野由美、舘脇康子、荒井啓行、瀧靖之
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] アルツハイマー病早期検出を目指したMRI 位相情報を用いる帯状回アミロイド蓄積検出の感度向上の試み2020

    • Author(s)
      田中 隆太郎、瀧石龍太、舘脇康子、武藤達士、石木愛子、冨田尚希、髙野由美、山本修三、荒井啓行、瀧靖之、米田哲也
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Hypoperfusion in the posterior cingulate cortex is associated with lower bone mass density in elderly women with osteopenia and Alzheimer’s disease2020

    • Author(s)
      Takano Y, Tatsushi M, Tatewaki Y, Seki T, Yamamoto S, Odagiri H, Arai H, Taki Y
    • Organizer
      European Congress of Radiology 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 非痙攣性てんかん重積の早期診断にMRI-ASL灌流画像が有用であった症例2020

    • Author(s)
      山本修三, 武藤達士, 舘脇康子, 高野由美, 鶴谷尚信, 渡部憲昭, 斎藤博, 米谷元裕, 荒井啓行, 瀧靖之, 安井信之.
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Study on feasible elemental statistics of MR-phase information for AD diagnosis2020

    • Author(s)
      Shinohara S, Yoneda T, Tatewaki Y, Thyreau B, Nagasaka T, Mutoh T, Arai H, Taki Y.
    • Organizer
      European Congress of Radiology 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRI を用いた脳一次視覚野の部位別の緑内障性変化の検出2019

    • Author(s)
      山田 晃生, 面高 宗子, 舘脇 康子, 檜森 紀子, 松平 泉 瀧 靖之, 中澤 徹
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高齢女性の骨量減少とアルツハイマー型認知症の脳血流低下領域との関係2019

    • Author(s)
      関 俊樹, 武藤 達士, 髙野 由美, 山本 修三, 舘脇 康子, 荒井 啓行, 瀧 靖之
    • Organizer
      第38回 日本認知症学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 高齢女性の骨量減少と認知機能に関連した脳血流低下領域との関係-医用画像による骨-脳連関の視覚化2019

    • Author(s)
      髙野 由美, 武藤 達士, 舘脇 康子, 山本 修三, 荒井 啓行, 瀧 靖之
    • Organizer
      第21回 日本骨粗鬆症学会
    • Related Report
      2019 Research-status Report
  • [Presentation] Positive correlation between trait anxiety and gray matter volume in the right temporal pole in Japanese glaucoma patients.2019

    • Author(s)
      Izumi Matsudaira, Yasuko Tatewaki, Kazuko Omodaka, Ryuta Kawashima, Toru Nakazawa, and Yasuyuki Taki
    • Organizer
      25th Organization for Human Brain Mapping
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 正常加齢の脳画像~性差や生活習慣に根差した形態変化~2019

    • Author(s)
      舘脇 康子
    • Organizer
      第8回あおば心・肺・脳カンファレンス
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 認知症診断におけるアミロイド-PADRE およびPiB の整合性の初期検討2018

    • Author(s)
      戸恒智子, 舘脇康子 , 石木愛子 , 米田哲也 , 犬童大貴, 呉花楠,明石敏昭, 永坂竜男, 高野由美, 荒井啓行 , 瀧靖之
    • Organizer
      第37回日本認知症学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Quantitative MR-Phase Information Enables Classification of AD stages2018

    • Author(s)
      Hiroki Indo, Tetsuya Yoneda, Nan Kurehana, Yasuko Tatewaki, Tatsushi Mutoh, Aiko Ishiki, Naoki Tomita, Hiroyuki Arai, Yasuyuki Taki
    • Organizer
      ECR
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] MRI位相画像情報を用いた定量的認知症評価法の基礎検討2018

    • Author(s)
      犬童大貴、米田哲也、舘脇康子、荒井啓行、呉花楠、瀧靖之
    • Organizer
      第8回日本認知症予防学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 臨床評価と相関する新しいMRI位相画像情報の探索2018

    • Author(s)
      米田哲也、犬童大貴、舘脇康子、荒井啓行、呉花楠、瀧靖之
    • Organizer
      第8回日本認知症予防学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Detect the glaucomatous nerve changes in optic radiation by DTI-NODDI2018

    • Author(s)
      山田晃生、 面高宗子, 舘脇康子, 松平泉, 下地啓五, 齊藤麻美, 川島隆太, 瀧靖之, 中澤徹
    • Organizer
      第29回日本緑内障学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 認知症診療における画像診断2018

    • Author(s)
      舘脇 康子
    • Organizer
      第3回 仙台北部地域連携セミナー
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 日常検査で役立つ脳神経領域画像の読み方2018

    • Author(s)
      舘脇 康子
    • Organizer
      宮城/山形MAGNETOM研究会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Patent(Industrial Property Rights)] 画像処理方法、プログラム、および画像処理装置2022

    • Inventor(s)
      舘脇康子、荒井晃、米田哲也
    • Industrial Property Rights Holder
      舘脇康子、荒井晃、米田哲也
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 画像処理方法、プログラム、および画像処理装置2021

    • Inventor(s)
      舘脇康子、荒井晃、米田哲也
    • Industrial Property Rights Holder
      舘脇康子、荒井晃、米田哲也
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-029161
    • Filing Date
      2021
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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