Exploring he dysfunction of glymphatic system in glaucoma using a novel MR imaging PADRE
Project/Area Number |
18K15580
|
Research Category |
Grant-in-Aid for Early-Career Scientists
|
Allocation Type | Multi-year Fund |
Review Section |
Basic Section 52040:Radiological sciences-related
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2022-03-31
|
Project Status |
Completed (Fiscal Year 2021)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 緑内障 / 認知症 / glymphatic system / アミロイドβ / 海馬 / 血管周囲腔 / MRI / アルツハイマー病 / 認知心理検査 |
Outline of Final Research Achievements |
1. There was no difference in hippocampal volume, which is related to cognitive function, between glaucoma and normal groups. On the other hand, a significant correlation was found between equivalent spherical power, a measure of myopia, and hippocampal volume especially in the glaucoma group. 2. We have developed new MRI images which enable to visualize of amyloid-β, and the image-processing program has been in domestic patent-pending and PCT filed. We have collected the special MRI images of approximately 200 glaucoma and normal subjects, and data analysis is currently underway. 3. There was no significant difference in parameters reflecting perivascular space volume between glaucoma and healthy groups. However, the reproducibility and reliability of the parameter we used in this analysis could not be established, and we create our own AI program for automatic measurement of the perivascular space for the sake of reanalyzing the data.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究は画像というアプローチから緑内障と認知症の共通病態の検証を行った。研究期間中、コロナ禍のためにデータ収集や解析が予定通り進まず、解析が可能だった範囲においては、緑内障と認知症を強く結びつける知見は得られなかった。 一方で、本検討に関連して、MRIでアミロイドβを可視化する新規画像を開発するという大きな成果を得た。非侵襲かつ廉価な本技術が実用化することで、本研究だけではなく、認知症臨床や各種認知症研究、治験などにおいても大きなブレークスルーとなることが期待される。
|
Report
(5 results)
Research Products
(44 results)
-
-
-
[Journal Article] Defining the Optimal Method for Measuring Metabolic Tumor Volume on Preoperative 18 F-Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography as a Prognostic Predictor in Patients With Pancreatic Ductal Adenocarcinoma2020
Author(s)
Tatewaki Y, Terao MC, Ariake K, Saito R, Mutoh T, Shimomura H, Motoi F, Mizuma M, Odagiri H, Unno M, Taki Y
-
Journal Title
Front Oncol.
Volume: 11
Pages: 646141-646141
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
[Journal Article] Morphological prediction of glaucoma by quantitative analyses of ocular shape and volume using 3-dimensional T2-weighted MR images.2019
Author(s)
Tatewaki Y, Mutoh T, Omodaka K, Thyreau B, Matsudaira I, Furukawa H, Yamada K, Kunitoki K, Kawashima R, Nakazawa T, Taki Y.
-
Journal Title
Sci Rep
Volume: 9
Issue: 1
Pages: 15148-15148
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
[Presentation] Impact of social activity on depressive symptoms and brain regional gray matter.2021
Author(s)
Yingxu Liu, Benjamin Thyreau, Yasuko Tatewaki, Ye Zhang, Izumi Matsudaira, Yuji Takano, Naoki Hirabayashi, Yoshihiko Furuta, Jun Hata, Toshiharu Ninomiya, Yasuyuki Taki.
Organizer
第40回日本認知症学会
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 非痙攣性てんかん重積の早期診断にMRI-ASL灌流画像が有用であった症例2020
Author(s)
山本修三, 武藤達士, 舘脇康子, 高野由美, 鶴谷尚信, 渡部憲昭, 斎藤博, 米谷元裕, 荒井啓行, 瀧靖之, 安井信之.
Organizer
第39回日本認知症学会学術集会
Related Report
-
-
-
-
-
-
-
[Presentation] 認知症診断におけるアミロイド-PADRE およびPiB の整合性の初期検討2018
Author(s)
戸恒智子, 舘脇康子 , 石木愛子 , 米田哲也 , 犬童大貴, 呉花楠,明石敏昭, 永坂竜男, 高野由美, 荒井啓行 , 瀧靖之
Organizer
第37回日本認知症学会学術集会
Related Report
-
-
-
-
-
-
-
-