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Investigation of the effect of contrast media on radiation exposure in cardiac CT and establishment of methods to reduce radiation dose

Research Project

Project/Area Number 18K15593
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKumamoto University

Principal Investigator

Kidoh Masafumi  熊本大学, 大学院生命科学研究部, 特任助教 (40744909)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心臓CT / 冠動脈CTA / 被曝 / 造影剤 / 冠動脈 / 心筋 / CT / 冠動脈CT / 心臓
Outline of Final Research Achievements

The purpose of this study was to clarify the relationship between contrast enhancement and radiation exposure in coronary CTA using Monte Carlo simulation. The results of the study suggested an increase in organ dose in contrast-enhanced CT (coronary CTA) using contrast agents compared to unenhanced CT without contrast agents.
This finding is expected to lead to optimization and individualization of CT scanning and contrast injection methods, and to enable coronary CTA with less burden on patients.

Academic Significance and Societal Importance of the Research Achievements

冠動脈CTAは冠動脈疾患の非侵襲的診断法の中心的役割を担い、本邦において年間42万件以上が施行されている。一方でX線による胸部領域の医療被曝は大きな問題であり、特に若年者の乳腺の被曝は将来の乳癌のリスクになりえるとの報告がある。近年、体幹部CTを中心に造影剤使用による被曝増加が懸念されているが、冠動脈CTAにおいての報告は認められない。本研究結果からは造影剤を使用しない単純CTと比較して、造影剤を使用する造影CT(冠動脈CTA)では臓器線量の増加が示唆された。冠動脈CTAにおいて造影剤(造影効果)と臓器被曝の関係が示されたことにより、撮像・造影方法の最適化、被曝低減につながるものと期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results)

  • [Journal Article] Effects of tube voltage and iodine contrast medium on radiation dose of whole-body CT2021

    • Author(s)
      Yoshida Morikatsu、Nakaura Takeshi、Oda Seitaro、Kidoh Masafumi、Nagayama Yasunori、Uetani Hiroyuki、Azuma M、Sakabe Daisuke、Hirai Toshinori、Funama Yoshinori
    • Journal Title

      Acta Radiologica

      Volume: 0 Issue: 4 Pages: 1-1

    • DOI

      10.1177/02841851211001539

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreasing the radiation dose for contrast-enhanced abdominal spectral CT with a half contrast dose: a matched-pair comparison with a 120 kVp protocol2020

    • Author(s)
      Daisuke Sakabe, Takeshi Nakaura, Seitaro Oda, Masafumi Kidoh, Daisuke Utsunomiya, Masahiro Hatemura, Yoshinori Funama
    • Journal Title

      British Journal Open

      Volume: 11 Issue: 1 Pages: 1-7

    • DOI

      10.1259/bjro.20200006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic evaluation of myocardial extracellular volume fraction using dual-layer spectral detector computed tomography2020

    • Author(s)
      Kidoh Masafumi、Oda Seitaro、Takashio Seiji、Tsujita Kenichi
    • Journal Title

      European Heart Journal - Case Reports

      Volume: 4 Issue: 6 Pages: 1-2

    • DOI

      10.1093/ehjcr/ytaa309

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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