Effect of LET of heavy ion beam on cancer metastasis

• Project/Area Number: 18K15632
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Osaka University
• Principal Investigator: Hayashi Kazuhiko 大阪大学, 医学系研究科, 特任助教(常勤) (70718981)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 炭素イオン線 / LET / 浸潤能 / 線エネルギー付与 / がん転移 / 細胞浸潤 / 細胞遊走

Outline of Final Research Achievements

LET contributes to the suppression of cancer invasive capabilities. The mechanism is the suppression of Rho family proteins involved in cell motility and invasion by the suppression of Calmodulin, which is involved in the regulation of intracellular calcium concentration by carbon-ion irradiation. In conclusion, the selection of LET for future carbon-ion therapy will be an important factor on not only cell killing effect but also inhibition of metastatic potentials.

Academic Significance and Societal Importance of the Research Achievements

炭素イオン線治療成績向上の為に、現在線エネルギー付与（LET）の増加が試みられている。一般的に、LETが増加すると同一線量であっても、殺細胞効果は高まる。
本研究課題では、LETの増加が殺細胞効果のみならずがん細胞の転移の一因となる、細胞浸潤能も抑制することを見出した。今後発展する粒子線治療の新たな有効性を見出したと言える。

Research Products

• [Journal Article] Carbon-ion radiotherapy for octogenarians with locally advanced non-small-cell lung cancer (2021)
  • Author(s): Hayashi Kazuhiko、Yamamoto Naoyoshi、Nakajima Mio、Nomoto Akihiro、Ishikawa Hitoshi、Ogawa Kazuhiko、Tsuji Hiroshi
  • Journal Title: Japanese Journal of Radiology Volume: X
  • DOI: 10.1007/s11604-021-01101-z
  • NAID: 210000177380
  • Peer Reviewed / Open Access
• [Journal Article] Safety and Efficacy of Carbon-ion Radiotherapy Alone for Stage III Non-small Cell Lung Cancer. (2020)
  • Author(s): Anzai M, Yamamoto N, Hayashi K, Nakajima M, Nomoto A, Ogawa K, Tsuji H.
  • Journal Title: Anticancer Res. Volume: 40(1) Issue: 1 Pages: 379-386
  • DOI: 10.21873/anticanres.13963
  • Peer Reviewed / Open Access
• [Journal Article] Stereotactic body radiotherapy feasibility for patients with peripheral stage I lung cancer and poor pulmonary function. (2020)
  • Author(s): Koba A, Hayashi K, Suzuki O, Kawaguchi Y, Ogawa K, Chatani M.
  • Journal Title: Oncol Lett. Volume: 19(3) Pages: 2515-2521
  • DOI: 10.3892/ol.2020.11333
• [Journal Article] Feasibility of Re-irradiation using carbon ions for recurrent head and neck malignancies after carbon-ion radiotherapy. (2019)
  • Author(s): Hayashi K, Koto M, Ikawa H, Hagiwara Y, Tsuji H, Ogawa K, Kamada T.
  • Journal Title: Radiother Oncol. Volume: 136 Pages: 148-153
  • DOI: 10.1016/j.radonc.2019.04.007
  • Peer Reviewed / Open Access