• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Myelin Imaging for Visualization and Clinical Application to Diagnosis of Demyelinating Disorders

Research Project

Project/Area Number 18K15643
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionJuntendo University

Principal Investigator

Maekawa Tomoko  順天堂大学, 医学部, 非常勤助手 (30813448)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsSynthetic MRI / ミエリン / 髄鞘 / 多発性硬化症 / 脱髄疾患 / 脱髄
Outline of Final Research Achievements

Myelin plays an important role in neurotransmission, and its evaluation may be useful in assessing brain diseases. Recently, myelin imaging by MRI has been developed and applied clinically. In particular, synthetic MRI enables quantitative values to be obtained in a single imaging scan, and myelin maps can be created in addition to any weighted Images without prolonging the scan time. The purpose of this study is to establish the best method for noninvasive assessment of myelin content in the body by performing and comparing Synthetic MRI and other myelin imaging techniques. In addition, I aim to create an imaging biomarker that will enable the diagnosis of demyelinating diseases such as multiple sclerosis, differentiation from other diseases, assessment of temporal changes, and determination of therapeutic efficacy.

Academic Significance and Societal Importance of the Research Achievements

Synthetic MRI(SyMRI)と最新の拡散イメージングを組み合わせた解析で脱髄プラークではミエリンの方が軸索よりも慢性的な障害が強いことが示唆された。また、SyMRIで得られるmyelin volume fraction (SyMRIMVF)と従来法のミエリン評価には強い相関を見出した。
加えて、SyMRIによる脳組織容量とミエリン量の推定において造影剤の影響により見かけ上の脳組織容量が変化しミエリンは増加して計測されることを見出した。これらの研究成果から、SyMRIによるミエリンイメージングは非侵襲的な生体内のミエリン量の評価や脱髄疾患における経時的評価に有用であることが示された。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (2 results) Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (6 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] Reims Champagne-Ardennes University(フランス)

    • Related Report
      2018 Research-status Report
  • [Int'l Joint Research] SyntheticMR AB(スウェーデン)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Multiple sclerosis plaques may undergo continuous myelin degradation: a cross-sectional study with myelin and axon-related quantitative magnetic resonance imaging metrics2021

    • Author(s)
      Maekawa Tomoko、Hagiwara Akifumi、Yokoyama Kazumasa、Hori Masaaki、Andica Christina、Fujita Shohei、Kamagata Koji、Wada Akihiko、Abe Osamu、Tomizawa Yuji、Hattori Nobutaka、Aoki Shigeki
    • Journal Title

      Neuroradiology

      Volume: 64 Issue: 3 Pages: 465-471

    • DOI

      10.1007/s00234-021-02781-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myelin Measurement Using Quantitative Magnetic Resonance Imaging: A Correlation Study Comparing Various Imaging Techniques in Patients with Multiple Sclerosis2020

    • Author(s)
      Saccenti Laetitia、Hagiwara Akifumi、Andica Christina、Yokoyama Kazumasa、Fujita Shohei、Kato Shimpei、Maekawa Tomoko、Kamagata Koji、Le Berre Alice、Hori Masaaki、Wada Akihiko、Tateishi Ukihide、Hattori Nobutaka、Aoki Shigeki
    • Journal Title

      Cells

      Volume: 9 Issue: 2 Pages: 393-393

    • DOI

      10.3390/cells9020393

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Gadolinium on the Estimation of Myelin and Brain Tissue Volumes Based on Quantitative Synthetic MRI.2019

    • Author(s)
      Maekawa T, Hagiwara A, Hori M, Andica C, Haruyama T, Kuramochi M, Nakazawa M, Koshino S, Irie R, Kamagata K, Wada A, Abe O, Aoki S.
    • Journal Title

      Am J Neuroradiol.

      Volume: 40 Issue: 2 Pages: 231-237

    • DOI

      10.3174/ajnr.a5921

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Advantage of Synthetic MRI for the Visualization of Anterior Temporal Pole Lesions on Double Inversion Recovery (DIR), Phase-sensitive Inversion Recovery (PSIR), and Myelin Images in a Patient with CADASIL2018

    • Author(s)
      Wallaert L, Hagiwara A, Andica C, Hori M, Yamashiro K, Koshino S, Maekawa T, Kamagata K, Aoki S.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 4 Pages: 275-276

    • DOI

      10.2463/mrms.ci.2017-0110

    • NAID

      130007496908

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myelin Measurement: Comparison Between Simultaneous Tissue Relaxometry, Magnetization Transfer Saturation Index, and T(1)w/T(2)w Ratio Methods.2018

    • Author(s)
      Hagiwara A, Hori M, Kamagata K, Warntjes M, Matsuyoshi D, Nakazawa M, Ueda R, Andica C, Koshino S, Maekawa T, Irie R, Takamura T, Kumamaru KK, Abe O, Aoki S
    • Journal Title

      Sci Rep.

      Volume: 8 Issue: 1 Pages: 10554-10554

    • DOI

      10.1038/s41598-018-28852-6

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Time-dependent Diffusion in Acute and Chronic Plaques of Multiple Sclerosis Investigated with Oscillating-gradient Spin-echo.2023

    • Author(s)
      Tomoko Maekawa
    • Organizer
      32th ISMRM International Society for Magnetic Resonance in Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oscillating-gradient spin-echo法を用いた多発性硬化症の急性期脱髄プラークの拡散時間依存性の評価2022

    • Author(s)
      前川朋子
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Association of estimated time from the onset of multiple sclerosis plaques with myelin and axon-related quantitative MRI measurement.2021

    • Author(s)
      前川朋子、萩原彰文、堀正明、Christina Andica、藤田翔平、明石敏昭、鎌形康司、和田昭彦、青木茂樹
    • Organizer
      30th ISMRM International Society for Magnetic Resonance in Medicine
    • Related Report
      2021 Research-status Report
  • [Presentation] 多発性硬化症プラークの発生からの推定経過時間とミエリン・軸索のMRIによる定量評価の関係性2020

    • Author(s)
      前川朋子 , 萩原彰文 , 堀正明 , Christina Andica , 藤田翔平 , 明石敏昭 , 鎌形康司 , 和田昭彦 , 青木茂樹
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Pitfall of synthetic MRI: Effect of gadolinium on the estimation of brain tissue volumes and myelin based on rapid simultaneous relaxometry2018

    • Author(s)
      Maekawa T, Hagiwara A, Hori M, Kamagata K, Andica C, Haruyama T, Sato K, Koshino S, Irie R, Wada A, Aoki S
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Rapid Myelin Measurement: Comparison Between SyMRI (Simultaneous Tissue Relaxometry), Magnetization Transfer Saturation Index, and T1w/T2w Ratio Methods2018

    • Author(s)
      Hagiwara A, Hori M, Kamagata K, Nakazawa M, Andica C, Maekawa T, Koshino S, Irie R, Chougar L, Abe O, Aok S
    • Organizer
      International Society for Magnetic Resonance in Medicine
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi