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Identification of Longitudinal Brain Maturation Patterns in Preterm Infants Using Quantitative Assessment

Research Project

Project/Area Number 18K15677
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionKyushu University

Principal Investigator

Sonoda Yuri  九州大学, 大学病院, 特任助教 (10813909)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords早産児 / 脳波定量的解析 / 脳成熟パターン / てんかん / 正期産児 / MRI定量解析 / NIRS / 定量的解析 / 脳成熟
Outline of Final Research Achievements

The purpose of this study is to quantitatively evaluate the brain by integrating functional connectivity and brain volume data, thereby elucidating precise brain maturation patterns for each preterm infant. In practice, due to difficulties in analyzing brain functional connectivity using near-infrared spectroscopy (NIRS), we identified EEG patterns reflecting the brain maturation process in children with epilepsy syndrome born at full term, aiming to evaluate functional connectivity. Quantitative analysis of the EEG shapes revealed morphological differences in EEG patterns by age. This suggests that these patterns may reflect the maturation process of the developing brain and could be useful for understanding the pathology of brain maturation patterns.

Academic Significance and Societal Importance of the Research Achievements

正期産児のてんかん症候群の児について、脳波形状を定量的に解析し、脳の成熟過程を反映していると考えられる脳波パターンを見出した。年齢による脳波の形態的差異が明らかとなったことは、発達期の脳の成熟過程を反映している可能性および、脳成熟パターンの病態解明に有用であるとともに、発達障害などの神経発達症の早期診断・早期介入や予後予測に今後有用となる可能性が示唆された。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (29 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (22 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 22 results,  Open Access: 17 results) Presentation (7 results)

  • [Journal Article] Progressive myoclonic epilepsy as an expanding phenotype of NGLY1-associated congenital deglycosylation disorder: A case report and review of the literature2024

    • Author(s)
      Sonoda Y, Fujita A, Torio M, Mukaino T, Sakata A, Matsukura M, Yonemoto K, Hatae K, Ichimiya Y, Chong PF, Ochiai M, Wada Y, Kadoya M, Okamoto N, Murakami Y, Suzuki T, Isobe N, Shigeto H, Matsumoto N, Sakai Y, Ohga S
    • Journal Title

      Eur J Med Genet

      Volume: 67 Pages: 104895-104895

    • DOI

      10.1016/j.ejmg.2023.104895

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-Titer Anti-ZSCAN1 Antibodies in a Toddler Clinically Diagnosed with Apparent Rapid-Onset Obesity with Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Syndrome2024

    • Author(s)
      Tocan V, Nakamura-Utsunomiya A, Sonoda Y, Matsuoka W, Mizuguchi S, Muto Y, Hijioka T, Nogami M, Sasaoka D, Nagamatsu F, Oba U, Kawakubo N, Hamada H, Mushimoto Y, Chong PF, Kaku N, Koga Y, Sakai Y, Oda Y, Tajiri T, Ohga S.
    • Journal Title

      Int J Mol Sci

      Volume: 29 Issue: 5 Pages: 2820-2820

    • DOI

      10.3390/ijms25052820

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Etiology and Outcome of Area Postrema Syndrome in Childhood: Two Cases and a Literature Review2024

    • Author(s)
      Tomari Y, Igata Y, Chong PF, Kajiwara K, Hatai E, Sonoda Y, Oba U, Kaku N, Koga Y, Sakai Y, Ohga S.
    • Journal Title

      Pediatr Neurol

      Volume: 152 Pages: 11-15

    • DOI

      10.1016/j.pediatrneurol.2023.12.010

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Persistent intracranial hyper-inflammation in ruptured cerebral aneurysm after COVID-19: case report and review of the literature2024

    • Author(s)
      Chong PF, Higashi K, Matsuoka W, Arimura K, Sangatsuda Y, Iwaki K, Sonoda Y, Ichimiya Y, Kamori A, Kawakami A, Mizuguchi S, Kaku N, Sakai Y, Ohga S.
    • Journal Title

      BMC Neurol

      Volume: 2 Issue: 1 Pages: 17-17

    • DOI

      10.1186/s12883-023-03493-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pediatric leukemia and maternal occupational exposure to anticancer drugs: the Japan Environment and Children’s Study2024

    • Author(s)
      Yamamoto Shunsuke、Sanefuji Masafumi、Suzuki Maya、Sonoda Yuri、Hamada Norio、Kato Wakako、Ono Hiroaki、Oba Utako、Nakashima Kentaro、Ochiai Masayuki、Kusuhara Koichi、Koga Yuhki、Ohga Shouichi
    • Journal Title

      Blood

      Volume: 143 Issue: 4 Pages: 311-319

    • DOI

      10.1182/blood.2023021008

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Divergent neurodevelopmental profiles of very-low-birth-weight infants2024

    • Author(s)
      Ogata R, Watanabe K, Chong PF, Okamoto J, Sakemi Y, Nakashima T, Ohno T, Nomiyama H, Sonoda Y, Ichimiya Y, Inoue H, Ochiai M, Yamashita H, Sakai Y, Ohga S.
    • Journal Title

      Pediatr Res

      Volume: 95 Issue: 1 Pages: 233-240

    • DOI

      10.1038/s41390-023-02778-w

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells2023

    • Author(s)
      Yonemoto K, Fujii F, Taira R, Ohgidani M, Eguchi K, Okuzono S, Ichimiya Y, Sonoda Y, Chong PF, Goto H, Kanemasa H, Motomura Y, Ishimura M, Koga Y, Tsujimura K, Hashiguchi T, Torisu H, Kira R, Kato TA, Sakai Y, Ohga S.
    • Journal Title

      Clin Immunol

      Volume: 255 Pages: 109756-109756

    • DOI

      10.1016/j.clim.2023.109756

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prenatal metal levels and congenital anomalies of the kidney and urinary tract: The Japan Environment and Children's Study2023

    • Author(s)
      Iwaya Yuka、Sanefuji Masafumi、Nishiyama Kei、Sonoda Yuri、Hamada Norio、Suga Reiko、Ochiai Masayuki、Shimono Masayuki、Kusuhara Koichi、Ohga Shouichi
    • Journal Title

      Science of The Total Environment

      Volume: 890 Pages: 164356-164356

    • DOI

      10.1016/j.scitotenv.2023.164356

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-lasting pain and somatosensory disturbances in children with myelin oligodendrocyte glycoprotein antibody-associated disease2023

    • Author(s)
      Ichimiya Yuko、Chong Pin Fee、Sonoda Yuri、Tocan Vlad、Watanabe Mitsuru、Torisu Hiroyuki、Kira Ryutaro、Takahashi Toshiyuki、Kira Jun-Ichi、Isobe Noriko、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      European Journal of Pediatrics

      Volume: 182 Issue: 7 Pages: 3175-3185

    • DOI

      10.1007/s00431-023-04989-z

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stroke in a protein C-deficient infant after stem cell transplant for CHARGE syndrome.2023

    • Author(s)
      Tanaka A, Sakaguchi Y, Inoue H, Egami N, Sonoda Y, Sonoda M, Ishimura M, Ochiai M, Hotta T, Uchiumi T, Sakai Y, Ohga S.
    • Journal Title

      Pediatr Blood Cancer

      Volume: 70 Issue: 4

    • DOI

      10.1002/pbc.30047

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children’s Study2022

    • Author(s)
      Inoue Hirosuke、Sanefuji Masafumi、Sonoda Yuri、et al.
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 15305-15305

    • DOI

      10.1038/s41598-022-19509-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between early formula and reduced risk of cow’s milk allergy during the first three year of life: a Japanese cohort study2022

    • Author(s)
      Ikari Kota、Tezuka Junichiro、Sanefuji Masafumi、et al.
    • Journal Title

      Allergy, Asthma & Clinical Immunology

      Volume: 18 Issue: 1 Pages: 71-71

    • DOI

      10.1186/s13223-022-00712-z

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes2022

    • Author(s)
      P. F. Chong, M. Torio, F. Fujii, Y. Hirata, W. Matsuoka, Y. Sonoda, et al.
    • Journal Title

      Eur J Clin Nutr

      Volume: 76 Issue: 11 Pages: 1618-1621

    • DOI

      10.1038/s41430-022-01170-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study2022

    • Author(s)
      Nishiyama Kei、Sanefuji Masafumi、Kurokawa Mari、et al.
    • Journal Title

      American Journal of Kidney Diseases

      Volume: 80 Issue: 5 Pages: 619-628

    • DOI

      10.1053/j.ajkd.2022.03.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age-related morphological differences in the spike-and-wave complexes of absence epilepsy2021

    • Author(s)
      Sonoda Yuri、Sanefuji Masafumi、Ichimiya Yuko、Torio Michiko、Watanabe Eriko、Sakata Ayumi、Ishizaki Yoshito、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Epilepsy Research

      Volume: 174 Pages: 106647-106647

    • DOI

      10.1016/j.eplepsyres.2021.106647

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis2021

    • Author(s)
      Sonoda Yuri、Sonoda Motoshi、Yonemoto Kousuke、Sanefuji Masafumi、Taira Ryoji、Motomura Yoshitomo、Ishimura Masataka、Torisu Hiroyuki、Kira Ryutaro、Kusuhara Koichi、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Journal of Neuroimmunology

      Volume: 358 Pages: 577656-577656

    • DOI

      10.1016/j.jneuroim.2021.577656

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Physical growth and neurodevelopment during the first year of life: a cohort study of the Japan Environment and Children’s Study2021

    • Author(s)
      Sanefuji Masafumi、Sonoda Yuri、Ito Yoshiya、Ogawa Masanobu、Tocan Vlad、Inoue Hirosuke、Ochiai Masayuki、Shimono Masayuki、Suga Reiko、Senju Ayako、Honjo Satoshi、Kusuhara Koichi、Ohga Shouichi、Kusuhara Koichi、Katoh Takahiko、Japan Environment and Children’s Study Group
    • Journal Title

      BMC Pediatrics

      Volume: 21 Issue: 1 Pages: 360-360

    • DOI

      10.1186/s12887-021-02815-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Breast feeding and infant development in a cohort with sibling pair analysis: the Japan Environment and Children’s Study2021

    • Author(s)
      Sanefuji Masafumi、Senju Ayako、Shimono Masayuki、Ogawa Masanobu、Sonoda Yuri、Torio Michiko、Ichimiya Yuko、Suga Reiko、Sakai Yasunari、Honjo Satoshi、Kusuhara Koichi、Ohga Shouichi
    • Journal Title

      BMJ Open

      Volume: 11 Issue: 8 Pages: e043202-e043202

    • DOI

      10.1136/bmjopen-2020-043202

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamin A deficiency?associated corneal perforation in a boy with autism spectrum disorder: A case report and literature review2021

    • Author(s)
      Adachi Shunichi、Torio Michiko、Okuzono Sayaka、Motomura Yoshitomo、Ichimiya Yuko、Sonoda Yuri、Nagata Jyunya、Okamoto Misato、Notomi Shoji、Sanefuji Masafumi、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Nutrition

      Volume: 90 Pages: 111275-111275

    • DOI

      10.1016/j.nut.2021.111275

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] De novo ATP1A3 variants cause polymicrogyria2021

    • Author(s)
      Miyatake Satoko、Kato Mitsuhiro、Kumamoto Takuma、Hirose Tomonori、他
    • Journal Title

      Science Advances

      Volume: 7 Issue: 13 Pages: 2368-2368

    • DOI

      10.1126/sciadv.abd2368

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possible association between early formula and reduced risk of cow’s milk allergy: The Japan Environment and Children’s Study2020

    • Author(s)
      Tezuka Junichiro、Sanefuji Masafumi、Ninomiya Takahito、Kawahara Takahiro、Matsuzaki Hiroshi、Sonoda Yuri、Ogawa Masanobu、Shimono Masayuki、Suga Reiko、Honjo Satoshi、Kusuhara Koichi、Ohga Shouichi、The Japan Environment, Children’s Study (JECS) Group
    • Journal Title

      Clinical & Experimental Allergy

      Volume: 51 Issue: 1 Pages: 99-107

    • DOI

      10.1111/cea.13761

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Child with Prostaglandin I<sub>2</sub>-associated Thyrotoxicosis: Case Report2019

    • Author(s)
      Sonoda Yuri、Yamamura Kenichiro、Ishii Kanako、Ohkubo Kazuhiro、Ihara Kenji、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Journal of Clinical Research in Pediatric Endocrinology

      Volume: 11 Issue: 2 Pages: 207-210

    • DOI

      10.4274/jcrpe.galenos.2018.2018.0169

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 先天性心疾患のフォローアップ中に硬膜動静脈瘻と診断された21 trisomyの6歳女児2023

    • Author(s)
      園田有里, 石倉稔也, 一宮優子, チョンピンフィー, 金政光, 本村良知, 平田悠一郎, 有村公一, 中溝 玲, 酒井康成, 大賀正一
    • Organizer
      第65回日本小児神経学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 神経変性ランゲルハンス細胞組織球症に対する大量免疫グロブリン療法の有効性2022

    • Author(s)
      園田有里、藤井史彦、園田素史、石村匡崇、一宮優子、チョンピンフィー、 米元耕輔、平良遼志、實藤雅文、古賀友紀、酒井康成、大賀正一
    • Organizer
      第64回日本小児神経学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 欠神てんかんの棘徐波複合における年齢依存性の形態的差異2022

    • Author(s)
      園田有里、實藤雅文、一宮優子、チョンピンフィー、酒井康成、大賀正一
    • Organizer
      第517回日本小児科学会福岡地方会例会
    • Related Report
      2022 Research-status Report
  • [Presentation] インターフェロンα脳室内投与により良好な長期経過を示した亜急性硬化性全脳炎の男児2021

    • Author(s)
      園田 有里, 園田 素史, 實藤 雅文, 一宮 優子, 鳥尾 倫子, 石崎 義人, 米元 耕輔, 平良 遼志, 藤井 史彦, 金政 光, 奥園 清香, 本村 良知, 酒井 康成, 大賀 正一
    • Organizer
      日本小児神経学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 欠神てんかんの棘徐波複合の形態は年齢によって異なる2021

    • Author(s)
      園田有里, 實藤雅文, 一宮優子, 鳥尾倫子, 渡邉恵利子, 酒田あゆみ, 石崎義人, 酒井康成, 大賀 正一
    • Organizer
      日本てんかん学会九州地方会
    • Related Report
      2021 Research-status Report
  • [Presentation] インターフェロンα脳室内投与により良好な長期経過を示した亜急性硬化性全脳炎の男児例2021

    • Author(s)
      園田有里、園田素史、實藤雅文、一宮優子、鳥尾倫子、石崎義人、米元耕輔, 平良遼志、藤井史彦、金政光、奥園清香、本村良知、酒井康成、大賀 正一
    • Organizer
      日本小児神経学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 当院小児神経外来における小児欠神てんかんの検討2020

    • Author(s)
      園田有里,實藤雅文,一宮優子、鳥尾倫子,米元耕輔,平良遼志,酒井康成,大賀正一
    • Organizer
      日本小児神経学会
    • Related Report
      2020 Research-status Report

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Published: 2018-04-23   Modified: 2025-01-30  

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