Elucidation of the pathogenesis of neurological deficits associated with neonatal chronic lung disease and development of novel therapeutic strategies using cells

• Project/Area Number: 18K15705
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Nagoya University
• Principal Investigator: Muramatsu Yukako 名古屋大学, 医学部附属病院, 病院助教 (10581522)
• Project Period (FY): 2018-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 新生児慢性肺疾患 / 神経学的障害

Outline of Final Research Achievements

Chronic lung disease (CLD) is a serious and frequent complication in neonatal medicine. The neurodevelopmental delay seen in the patients with CLD is an one of the most important problem, and there are no treatments for the neurological consequences of CLD.
The purpose of this study is to investigate the pathogenesis of the neurological consequences in detail and to conduct basic research that will lead to novel treatments.

Academic Significance and Societal Importance of the Research Achievements

CLDにともなう精神運動発達遅滞は重要な問題であるが、その方策は皆無である。詳細に病態を解明し、新規治療法の開発を目指す本研究の成果は、新生児医療の向上に大きく寄与すると考えられる。