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Analysis of the effect of HPGDS pathway on synaptic pruning and its involvement in autism by iPS cells and 3D co-culture

Research Project

Project/Area Number 18K15707
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionOsaka University

Principal Investigator

Tachibana Masaya  大阪大学, 連合小児発達学研究科, 特任准教授(常勤) (10722952)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsニューロン / ミクログリア / iPS細胞 / 自閉スペクトラム症 / 神経炎症 / プロスタグランジンD2 / シナプス / 自閉症 / HPGDS
Outline of Final Research Achievements

In this study, we focused on the inflammatory mediator prostaglandin D2 (PGD2) and hematopoietic prostaglandin D synthase (HPGDS), which is expressed strongly in microglia of autistic individuals, to investigate the involvement of the HPGDS-PGD2 pathway in the synapse formation of neurons and synaptic pruning. Forced expression of HPGDS in human iPS cells resulted in changes in differentiation speed. In addition, experiments in mice showed that PGD2 affects synaptic morphology and maturation of neurons; the effects of HPGDS-PGD2 on microglia will be continued in the succeeding project, Fundamental Research C.

Academic Significance and Societal Importance of the Research Achievements

自閉スペクトラム症(ASD)においてはシナプス刈込異常のその病態への関与が指摘されている。一方で自閉スペクトラム症への神経炎症の関与が繰り返し示唆されている。自閉スペクトラム症において強く発現するHPGDSとその合成産物であるHPGDS-PGD2経路については、その阻害薬が既に開発されており、そのニューロンやシナプスへの影響を明らかにすることにより、ASDに対する新規治療法開発にもつながりうる。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (27 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (5 results) Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 3 results) Presentation (15 results) (of which Int'l Joint Research: 1 results)

  • [Int'l Joint Research] Mayo Clinic(米国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Universitas Indonesia(インドネシア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] University of Malaya(マレーシア)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Phlippine Children's Medical Center(フィリピン)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] Mahidol University(タイ)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Effectiveness of a Parent Training Programme for Parents of Adolescents with Autism Spectrum Disorders: Aiming to Improve Daily Living Skills.2022

    • Author(s)
      Matsumura N, Fujino H, Yamamoto T, Tanida Y, Ishii A, Tatsumi A, Nakanishi M, Tachibana M, Mohri I, Okuno H.
    • Journal Title

      Int J Environ Res Public Health

      Volume: 19(4) Issue: 4 Pages: 2363-2363

    • DOI

      10.3390/ijerph19042363

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Japanese Sleep Questionnaire for Preschoolers within a Malaysian context.2022

    • Author(s)
      Jayanath S, Hamzah N, Ahmad Fauzi A, Syarinaz Ahmad Adlan A, Asiah Muhamad N, Zaiti Zainal A, Mohri I, Tachibana M.
    • Journal Title

      Pediatrics International

      Volume: - Issue: 1

    • DOI

      10.1111/ped.15123

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 発達評価(新版K式発達検査、WISC、M-CHAT、ASD、ADHDのスクリーニングスケール2022

    • Author(s)
      山本知加、橘 雅弥
    • Journal Title

      with NEO

      Volume: 35(2) Pages: 120-125

    • Related Report
      2021 Annual Research Report
  • [Journal Article] The relationship between multisensory hypersensitivity and behavioral problems in children with autism spectrum disorders2021

    • Author(s)
      Kamiya C, Kagitani-Shimono K, Iwatani Y, Tachibana M, Mohri I, Taniike M.
    • Journal Title

      Journal of Brain Science

      Volume: 50 Issue: 0 Pages: 63-100

    • DOI

      10.20821/jbs.50.0_63

    • NAID

      130008141265

    • ISSN
      1341-5301, 2432-2512
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationships between cortical, cardiac, and arousal-motor activities in the genesis of rhythmic masticatory muscle activity across sleep cycles in primary sleep bruxism children.2021

    • Author(s)
      Shiraishi Y, Tachibana M, Shirota A, Mohri I, Taniike M, Yamashiro T, Kato T.
    • Journal Title

      Sleep

      Volume: 44(11) Issue: 11 Pages: 0-0

    • DOI

      10.1093/sleep/zsab156

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] APOE2 is associated with longevity independent of Alzheimer’s disease2020

    • Author(s)
      Shinohara Mitsuru、Kanekiyo Takahisa、Tachibana Masaya、Kurti Aishe、Shinohara Motoko、Fu Yuan、Zhao Jing、Han Xianlin、Sullivan Patrick M、Rebeck G William、Fryer John D、Heckman Michael G、Bu Guojun
    • Journal Title

      eLife

      Volume: 9

    • DOI

      10.7554/elife.62199

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alzheimer’s Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways2020

    • Author(s)
      Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton LM,… , Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu CC, Storz P, Asmann YW, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, Bu G
    • Journal Title

      Neuron

      Volume: 106 Issue: 5 Pages: 727-742.e6

    • DOI

      10.1016/j.neuron.2020.02.034

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 胎児期におけるPGD2シグナル活性化による社会性行動や神経細胞形態への影響2021

    • Author(s)
      菊池泰河,早田敦子,毛利育子,橘 雅弥,谷池雅子,橋本 均
    • Organizer
      第140回日本薬理学会近畿部会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 双方向性スマートフォンアプリ「ねんねなび」による幼児の睡眠習慣への介入 ー社会実装による有用性検討ー2021

    • Author(s)
      吉崎亜里香,山本知加,村田絵美,花家竜三,平田郁子,橘 雅弥,毛利育子,谷池雅子
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中国語版「子どもの眠りの質問票」をつかった中国青海省における子どもの睡眠調査2021

    • Author(s)
      蘇 平,橘 雅弥,谷池雅子,毛利育子
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] どものこころの発達研究センターから展開するアジア発達障害共同研究拠点形成と共同利用推進2021

    • Author(s)
      橘 雅弥,片山泰一,谷池雅子,横山茂,土屋賢治,平野好幸,清水栄司,松﨑秀夫,友田明美,中村和彦,佐藤真
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 幼児の睡眠に影響を与える生活習慣の検討2021

    • Author(s)
      村田絵美,吉崎亜里香,毛利育子,橘 雅弥,谷池雅子
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中高大学生による発達障害に関する課題解決の取り組み ーinochi Gakusei Innovators' Program 2020の成果2021

    • Author(s)
      相良壮馬,村田七海,中原一帆,橘 雅弥
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 発達障害(ADHD/ASD)を有する患児の周術期心理支援~チャイルド・ライフ・スペシャリスト(CLS)による治癒的介入~2021

    • Author(s)
      馬戸史子,橘雅弥,石田秀和,平将生,細川清人,奥山宏臣
    • Organizer
      第31回小児外科QOL研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大学病院小児科における科内発達障害カンファレンスの意義2020

    • Author(s)
      橘雅弥, 中西真理子, 酒井佐枝子, 平田郁子, 下野九理子, 毛利育子, 大薗恵一, 谷池雅子
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 学業の過負荷がゲーム・ネット依存の引き金となった発達障害児2症例の検討2020

    • Author(s)
      毛利育子, 中西真理子, 橘雅弥, 下野九理子, 谷池雅子
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大学病院発達外来における受診のニーズと課題2020

    • Author(s)
      下野九理子, 平田郁子, 橘雅弥, 岩谷祥子, 富永康仁, 中西真理子, 毛利育子, 大薗恵一, 谷池雅子
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 当院におけるナルコレプシーの臨床経過2020

    • Author(s)
      平田郁子, 橘雅弥, 毛利育子, 大薗恵一, 谷池雅子
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 自閉スペクトラム症における脳波異常の検討2020

    • Author(s)
      岩谷祥子, 毛利育子, 中西真理子, 橘雅弥, 平田郁子, 富永康仁, 大薗恵一, 谷池雅子, 下野九理子
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Usefulness of sensory profile as a biomarker for autism spectrum disorder2020

    • Author(s)
      Kamiya C, Kagitani-Shimono K, Nakanishi M, Tachibana M, Mohri I, Taniike M
    • Organizer
      International Society for Autism Research 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prostaglandin D2 modulates neuronal morphological development via activation of DP1 receptor2019

    • Author(s)
      Hayata-Takano A, Mohri I, Okuda K, Tachibana M, Kikuchi T, Shintani Y, Nakazawa T, Taniike M, Hashimoto H
    • Organizer
      NEURO2019
    • Related Report
      2019 Research-status Report
  • [Presentation] マウス新生仔へのプロスタグランジンD2受容体DP1作動薬による神経細胞の形態や行動への影響2018

    • Author(s)
      早田 敦子、奥田 健太、毛利 育子、橘 雅弥、新谷 勇介、菊池 泰河、中澤 敬信、谷池 雅子、橋本 均
    • Organizer
      第48回日本神経精神薬理学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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