Pathophysiology of acute encephalopathy associated with cytokine storm using clinical samples combined with clinical database
| Project/Area Number |
18K15711
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | acute encephalopathy / cytokine / inflammation / status epilepticus / 急性脳症 / 炎症 / サイトカイン / 熱性けいれん / けいれん重積 / 病態 |
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| Outline of Final Research Achievements |
Acute encephalopathy is a major neurological syndrome characterized by acute onset of severe and long-lasting disturbance of consciousness, which typically occur in previously healthy children. Acute encephalopathy associated with cytokine storm is the most severe syndrome among those syndromes. However, specific treatment strategy for this conditions yet to be established. Therefore, we have researched the pathophysiology of acute encephalopathy associated with cytokine storm using clinical samples combined with clinical database. In this research, we have provided the new insights on the pathophysiology and a detailed clinical picture of acute encephalopathy associated with cytokine by a comprehensive analysis of inflammatory biomarkers. Further, we have suggested that earlier aggressive anti-inflammation treatment might prevent sequelae in these conditions. More comprehensive analysis on pathophysiology and specific treatment strategy for each pathophysiology are needed.
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| Academic Significance and Societal Importance of the Research Achievements |
急性脳症は、生来健康であった乳幼児に認知障害・麻痺・てんかんなどの重篤な後遺症を残す疾患で、年間700人の発症があると推定されている。本研究では、急性脳症における炎症病態のダイナミックな変化が明らかとなった。臨床情報とともに解析できたことで、至適時期に抗炎症治療を行うための重要な知見も得られた。本研究で得られた成果をもとに、急性脳症の治療戦略確立が期待される。予後不良なサイトカインストーム型急性脳症の死亡・後遺症軽減を達成することは、患児本人や家族はもちろん、社会全体にとっても重要である。
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Prediction of AESD and neurological sequelae in febrile status epilepticus2021
Author(s)
Nishiyama M, Ishida Y, Yamaguchi H, Tokumoto S, Tomioka K, Hongo H, Toyoshima D, Maruyama A, Kurosawa H, Tanaka R, Nozu K, Iijima K, Nagase H
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Journal Title
Brain Dev
Volume: 43
Issue: 5
Pages: 616-625
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Thiamylal anaesthetic therapy for febrile refractory status epilepticus in children2020
Author(s)
Ishida Y, Nishiyama M, Yamaguchi H, Tomioka K, Tanaka T, Takeda H, Tokumoto S, Toyoshima D, Maruyama A, Seino Y, Aoki K, Nozu K, Nishimura N, Kurosawa H, Iijima K, Nagase H
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Journal Title
Seizure
Volume: 80
Pages: 12-17
DOI
Related Report
Peer Reviewed
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[Journal Article] Acute rhabdomyolysis following viral infection with coxsackie A4 in a 50-day-old infant with Fukuyama congenital muscular dystrophy2020
Author(s)
Yamaguchi H, Taniguchi-Ikeda M, Nagase H, Ito Y, Tokumoto S, Toyoshima D, Enkhjargal S, Nishiyama M, Awano H, Kurosawa H, Kasai M, Maruyama A, Iijima K
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Journal Title
J Infect Chemother
Volume: 26
Issue: 5
Pages: 516-519
DOI
Related Report
Peer Reviewed
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[Journal Article] Detailed characteristics of acute encephalopathy with biphasic seizures and late reduced diffusion: 18-year data of a single-center consecutive cohort.2020
Author(s)
Yamaguchi H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Aoki K, Seino Y, Toyoshima D, Takeda H, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Iijima K, Nagase H.
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Journal Title
J Neurol Sci.
Volume: 411
Pages: 116684-116684
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Detailed clinical course of fatal acute encephalopathy in children.2019
Author(s)
Tomioka K, Nishiyama M, Nagase H, Ishida Y, Tanaka T, Tokumoto S, Yamaguchi H, Toyoshima D, Maruyama A, Fujita K, Aoki K, Seino Y, Nozu K, Nishimura N, Kurosawa H, Iijima K.
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Journal Title
Brain Dev.
Volume: 41
Issue: 8
Pages: 691-698
DOI
NAID
Related Report
Peer Reviewed
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