• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of a new fetal therapy for twin-to-twin transfusion syndrome using high intensity focused ultrasound

Research Project

Project/Area Number 18K15731
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionShowa University

Principal Investigator

Seo Kohei  昭和大学, 医学部, 講師 (70791440)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2018: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
KeywordsHIFU / TTTS / 分割トランスデューサー / 焦点可視化 / 可変焦点式 / 動物実験 / 6分割トランスデューサーの作成 / 焦点可視化プログラムの実装 / 委員会承認 / 集束超音波 / 双胎間輸血症候群 / 胎児治療
Outline of Final Research Achievements

Objectives are improving the HIFU system and establishing fetal treatment for TTTS. Planed methods were 1. introduction of divided transducer, 2. introduction of phase modulation method, 3. implementation of focus visualization program, 4. changing to variable focus method, 5. introduction of HIFU noise removal method, 6. introduction of treatment monitoring, animal experiments, clinical irradiation. 1. Successful reduction of skin burns in animal experiments, 3. Successful focus visualization and prediction of unintended fever in animal experiments, and 4. Successful performance improvement to variable focus type. On the other hand, the progress was not as planned due to COVID-19 pandemicthe, such as closure of the animal experiment facility, the restriction of movement, and the stagnation of delivery. Therefore, the research plan was changed to make the system safer, more accurate, and more efficient without rushing to start clinical practice.

Academic Significance and Societal Importance of the Research Achievements

多くの胎児治療は、子宮を穿刺し医療機器を羊水腔内へ挿入するため、穿刺に伴う合併症が、胎児治療成功の可否に拘らず出生児の予後を左右する可能性がある。HIFUは数ミリの範囲に超音波を収束させ組織を熱変性させる治療法である。本研究成果は子宮、胎盤に極めて低侵襲な胎児非接触治療法として、細かい血管焼灼を要するTTTSに対する胎児治療の確立を促進した。この成果は他の胎児疾患だけでなく、身体内深部の穿刺が危険な臓器への応用も期待され将来の医療発展へ貢献する可能性がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2020 2019 2018

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] High-intensity focused ultrasound for noninvasive fetal therapy2022

    • Author(s)
      Ichizuka Kiyotake、Seo Kohei、Izudepski Tetsuya、Nagatsuka Masaaki
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: -

    • DOI

      10.1007/s10396-022-01199-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of an HIFU exposure protocol for reducing skin burn risk2020

    • Author(s)
      Shogo Nishii, Kohei Seo(Corresponding author)
    • Journal Title

      Online ISSN : 2185-0968 Print ISSN : 0915-6380 ISSN-L : 0915-6380

      Volume: in publication

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Twin-Reversed Arterial Perfusion Sequence Using High-Intensity Focused Ultrasound Therapy2018

    • Author(s)
      Seo Kohei、Ichizuka Kiyotake、Okai Takashi、Dohi Satoshi、Nakamura Masamitsu、Hasegawa Junichi、Matsuoka Ryu、Yoshizawa Shin、Umemura Shin-ichiro、Nagatsuka Masaaki、Sekizawa Akihiko
    • Journal Title

      Ultrasound in Obstetrics & Gynecology

      Volume: 印刷中 Issue: 1 Pages: 128-134

    • DOI

      10.1002/uog.20101

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Twin‐reversed arterial perfusion sequence using high‐intensity focused ultrasound therapy2019

    • Author(s)
      Kohei Seo
    • Organizer
      ISUOG world congress 2018
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 焦点ナビゲーション法のHIFU治療への応用2019

    • Author(s)
      瀬尾晃平
    • Organizer
      日本超音波医学会学術集会2018
    • Related Report
      2019 Research-status Report
  • [Presentation] 皮膚熱傷を低減させるためのHIFU照射プロトコールの検証2019

    • Author(s)
      西井彰悟
    • Organizer
      日本超音波医学会学術集会2018
    • Related Report
      2019 Research-status Report
  • [Presentation] HIFU照射方式の違いによるブタ腎実質焼灼の比較検証2019

    • Author(s)
      イズデプスキ龍也
    • Organizer
      日本超音波医学会学術集会2018
    • Related Report
      2019 Research-status Report
  • [Presentation] Twin-Reversed Arterial Perfusion Sequence Using High-Intensity Focused Ultrasound Therapy.2018

    • Author(s)
      K Seo
    • Organizer
      ISUOG 2018- 28th World Congress - Singapore
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi