• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Fuction of m6A RNA modifications in human placenta.

Research Project

Project/Area Number 18K15737
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionNational Center for Child Health and Development

Principal Investigator

Taniguchi Kosuke  国立研究開発法人国立成育医療研究センター, メディカルゲノムセンター, 研究員 (90808718)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsmRNAメチル化 / N6メチルアデノシン / 胎盤 / 胎児発育 / 妊娠高血圧腎症 / エピトランスクリプトーム / トランスクリプトーム / RNAメチル化 / RNA / N6-Methyladenosine / epitranscriptome / N6-メチルアデノシン / 転写後修飾
Outline of Final Research Achievements

The association between N6-methyladenosine (m6A) -a typical mRNA methylation modification- and disease have begun to be reported. However, the function of m6A modification in human placenta has not been elucidated.
In this study, we performed a comprehensive m6A analysis using the human placenta of various birth weight neonates and a pregnancy complication in order to elucidate the function of m6A modification in the human placenta.
The m6A at the 5'UTR of placental mRNA had unique m6A modification in each fetal development group and a pregnancy complication group. We identified a number of mRNAs that showed a significant difference in the amount of m6A in each fetal development group and a pregnancy complication group compared with the control group, although there was no difference in the expression level. Our results suggested that the m6A at the 5'UTR might promote protein translation, which could affect placental function.

Academic Significance and Societal Importance of the Research Achievements

本研究では、ヒト胎盤でのm6A修飾の機能を世界で初めて報告した。様々な胎児発育例や妊娠合併症の病態解明において、mRNA量の比較では同定できなかった関連遺伝子を多数同定し得た。mRNAメチル化修飾による転写後調節を考慮することで、詳細や原因が未だ不明である生体現象や疾患の病態解明に役立つことが予想される。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2020

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Epitranscriptomic profiling in human placenta: N6‐methyladenosine modification at the 5′‐untranslated region is related to fetal growth and preeclampsia2020

    • Author(s)
      Taniguchi Kosuke、Kawai Tomoko、Kitawaki Jo、Tomikawa Junko、Nakabayashi Kazuhiko、Okamura Kohji、Sago Haruhiko、Hata Kenichiro
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 1 Pages: 494-512

    • DOI

      10.1096/fj.201900619rr

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi