| Project/Area Number |
18K15782
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 炎症性腸疾患 / ATP |
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| Outline of Final Research Achievements |
Dextran Sulfate Sodium (DSS) colitis was induced in the GO-ATeam expressed mice, and the ATP concentration in the intestine was measured by in vivo observation by the fluorescence stereomicroscop. The intestinal ATP concentration in the DSS colitis model mice was significantly higher than in the control mice. The ATP concentration was higher not only in the intestine but also in the brain of the DSS colitis model mice. The observation by transmission electron microscope revealed the aberration of the neural mitochondria of the brain in the DSS colitis model mice compared with the control mice.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は炎症性腸疾患(IBD)モデルマウスにおいて細胞内ATP濃度が細胞・臓器の機能に与える影響について明らかにし、エネルギー産生異常の観点からIBDの病態の解明の端緒とすることを目的とした。本研究結果から腸炎に伴って中枢神経でのエネルギー代謝異常が生じている事が示唆された。中枢神経系でのミトコンドリア機能異常は様々な精神疾患メカニズムの一つとして着目されており、この結果は腸と脳の他臓器連関のメカニズムの解明における重要な糸口となる可能性がある。
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