Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Outline of Final Research Achievements |
We developed a new hepatocarcinogenesis model (DEN+AMLN model) with obesity, insulin resistance, and liver fibrosis using the AMLN model, which is a food-induced model similar to the human NAFLD/NASH. We used the liver chemo-carcinogen diethylnitrosamine and B6C3F1 mice for chemoprevention using SGLT2 inhibitors and PPARα, which are potential therapeutic agents for NAFLD, and also examined differences in carcinogenesis due to differences in diet.
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