| Project/Area Number |
18K15828
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
Suzuki Hiroka 愛知学院大学, 薬学部, 講師 (00581026)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Piezo1チャネル / 肝線維化 |
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| Outline of Final Research Achievements |
We showed that functional expression of Piezo1 in hepatic stellate cells and examined the effect of transforming growth factor-β (TGF-β) to functional expression of Piezo1. Also, we investigated the effect of Piezo1 agonist to activation of hepatic stellate cells by TGF-β. Furthermore, we found out intracellular localization of Piezo1 in hepatic stellate cells and investigated contractile activity of activated hepatic stellate cells caused by enhancement of intracellular Ca2+ level.
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| Academic Significance and Societal Importance of the Research Achievements |
肝星細胞は肝線維化進展において非常重要な役割を担っている。そのため、肝星細胞の細胞機能を解析することは、肝線維化治療および肝硬変など様々な肝疾患治療につながる。
本研究によりPiezo1が肝線維化に及ぼす影響を明らかにすることで、新たな肝線維化治療薬開発につながることが期待される。また、未だ不明な点が多いPiezo1について新たな知見が得られると考えられる。
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