A multicenter study focusing on coronary artery disease in patients with heart failure

• Project/Area Number: 18K15862
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Juntendo University
• Principal Investigator: Matse Yuya 順天堂大学, 医学部, 准教授 (50811642)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心不全 / 冠動脈疾患 / 疫学研究 / 多施設レジストリ研究 / 予後 / 高齢者 / 疫学

Outline of Final Research Achievements

Using the REALITY-AHF database, a prospective, multicenter acute heart failure registry study conducted from 2014 to 2016, we investigated the rate of performing coronary catheterization and its association with prognosis among hospitalized patients with heart failure in Japan. The results showed that 38% of patients were catheterized and that patients who were catheterized had a higher survival rate than those who were not catheterized. In a newly initiated prospective multicenter registry study focusing on coronary catheterization at four institutions in Japan, 300 hospitalized patients with heart failure have been already enrolled, and the results were very similar to those of the REALITY-AHF database in terms of coronary catheterization rates.

Academic Significance and Societal Importance of the Research Achievements

これまで冠動脈疾患合併心不全患者は、心不全患者に焦点を当てた研究においては主に過去の冠動脈疾患歴の有無のみで虚血性・非虚血性心不全のサブグループとして扱われ、一方、冠動脈疾患患者に焦点を当てた研究においては心不全合併サブグループとして扱われてきた。しかし、これでは冠動脈疾患合併心不全患者について詳細に記述する事は不可能であり、本研究はこの疾患群を中心に据えた上で詳細にその特徴などを記述しているという点においてこれまでの研究とは異なり学術的意義が高いと考えられる。今後はどのような患者でより冠動脈カテーテル検査が勧められるかを症例を蓄積し検討する必要がある。

Research Products

• [Journal Article] Usefulness of Incorporating Hypochloremia into the Get With The Guidelines?Heart Failure Risk Model in Patients With Acute Heart Failure (2022)
  • Author(s): Misumi Kayo、Matsue Yuya、et al.
  • Journal Title: The American Journal of Cardiology Volume: 162 Pages: 122-128
  • DOI: 10.1016/j.amjcard.2021.09.020
  • Peer Reviewed
• [Journal Article] Inaccurate recognition of own comorbidities is associated with poor prognosis in elderly patients with heart failure (2022)
  • Author(s): Maeda Daichi、Matsue Yuya、et al.
  • Journal Title: ESC Heart Failure Volume: 9 Issue: 2 Pages: 1351-1359
  • DOI: 10.1002/ehf2.13824
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endomyocardial Biopsy for the Diagnosis of Transthyretin Cardiac Amyloidosis in the Era of Multimodality Imaging (2021)
  • Author(s): Sunayama Tsutomu、Matsue Yuya、Doi Shinichiro、Okai Iwao、Dohi Tomotaka、Aoshima Chihiro、Miyazaki Sakiko、Hayashi Hidemori、Kasai Takatoshi、Fujimoto Shinichiro、Okazaki Shinya、Shimada Kazunori、Daida Hiroyuki
  • Journal Title: Circulation Reports Volume: 3 Issue: 10 Pages: 627-628
  • DOI: 10.1253/circrep.CR-21-0051
  • NAID: 130008102380
  • ISSN: 2434-0790
  • Year and Date: 2021-10-08
  • Peer Reviewed
• [Journal Article] Standardized gait speed ratio in elderly patients with heart failure (2021)
  • Author(s): Ozawa Tetsuya、Matsue Yuya et al.
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 5 Pages: 3557-3565
  • DOI: 10.1002/ehf2.13392
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence and prognostic implications of malnutrition as defined by GLIM criteria in elderly patients with heart failure. (2021)
  • Author(s): Hirose S, Matsue Y*, Kamiya K, Kagiyama N, Hiki M, Dotare T, Sunayama T, Konishi M, Saito H, Saito K, Ogasahara Y, Maekawa E, Kitai T, Jujo K, Wada H, Kasai T, Momomura SI, Minamino T.
  • Journal Title: Clin Nutr. Volume: in-press Issue: 6 Pages: 4334-4340
  • DOI: 10.1016/j.clnu.2021.01.014
  • Peer Reviewed
• [Journal Article] Impact of Social Frailty in Hospitalized Elderly Patients With Heart Failure: A FRAGILE‐HF Registry Subanalysis (2021)
  • Author(s): Jujo Kentaro、Matsue Yuya、et al.
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 17
  • DOI: 10.1161/jaha.120.019954
  • Peer Reviewed / Open Access
• [Journal Article] Multidomain Frailty in Heart Failure: Current Status and Future Perspectives (2021)
  • Author(s): Tanaka Shinya、Yamashita Masashi、Saito Hiroshi、Kamiya Kentaro、Maeda Daichi、Konishi Masaaki、Matsue Yuya
  • Journal Title: Current Heart Failure Reports Volume: 18 Issue: 3 Pages: 107-120
  • DOI: 10.1007/s11897-021-00513-2
  • Peer Reviewed / Open Access
• [Journal Article] Aspartate aminotransferase to alanine aminotransferase ratio is associated with frailty and mortality in older patients with heart failure (2021)
  • Author(s): Maeda Daichi、Matsue Yuya、et al.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-91368-z
  • Peer Reviewed / Open Access
• [Journal Article] Standardized gait speed ratio in elderly patients with heart failure. (2021)
  • Author(s): Ozawa T, Yamashita M, Seino S, Kamiya K, Kagiyama N, Konishi M, Saito H, Saito K, Ogasahara Y, Maekawa E, Kitai T, Iwata K, Jujo K, Wada H, Kasai T, Momomura SI, Hamazaki N, Nozaki K, Kim HK, Obuchi S, Kawai H, Kitamura A, Shinkai S, Matsue Y.
  • Journal Title: ESC Heart Fail. Volume: - Pages: 296-303
  • DOI: 10.1016/j.ijcard.2017.02.016
  • Peer Reviewed / Open Access
• [Journal Article] Impact of social frailty in hospitalized elderly patients with heart failure: A FRAGILE-HF registry subanalysis. (2021)
  • Author(s): Jujo K, Kagiyama N, Saito K, Kamiya K, Saito H, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Wada H, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Yonezawa R, Oka K, Makizako H, Momomura SI, Matsue Y
  • Journal Title: J Am Heart Assoc. Volume: -
  • Peer Reviewed
• [Journal Article] Safety and Prognostic Impact of Early Treatment With Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers in Patients With Acute Heart Failure (2019)
  • Author(s): oshioka K, Matsue Y, Yamaguchi T, Kitai T, Kagiyama N, Okumura T, Kida K, Oishi S, Akiyama E, Suzuki S, Yamamoto M, Kuroda S, Matsumura A, Hirao K.
  • Journal Title: Am J Cardiovasc Drugs . Volume: 19 Pages: 597-605
  • Peer Reviewed
• [Presentation] Massage from Japanese Heart Failure Registry- How should We Change in the Current Practice of HF? (2020)
  • Author(s): Matsue Y.
  • Organizer: 第84回日本循環器学会学術集会
  • Int'l Joint Research / Invited
• [Presentation] Controversies on the Management of Heart Failure. (2020)
  • Author(s): Matsue Y.
  • Organizer: 第84回日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] 急性心不全治療のコントラバーシー (2020)
  • Author(s): 末永 祐哉
  • Organizer: 第84回日本循環器学会学術集会
  • Int'l Joint Research