• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Functional and structural regulations of small conductance Ca2+-activated K+ channels with Ca2+/calmodulin-dependent protein kinase

Research Project

Project/Area Number 18K15874
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionHokkaido University

Principal Investigator

Temma Taro  北海道大学, 医学研究院, 客員研究員 (00801614)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords致死的不整脈 / SKチャネル / CaMKII / 虚血心 / 肥大心 / 分子標的治療
Outline of Final Research Achievements

SK channels were activated in the several diseased hearts. The function of SK channels was regulated with activatedCaMKII. These results were published at peer reviewed journals (Am J Physiol Heart Circ Physiol. 2018;315(2):H262-H272, Eur J Pharmacol. 2019;844:110-117). The inhibition of the hearts with CaMKII inhibitor made the SK channels expression decreased in the cell membrane fractions.
CaMKII regulated the both function and structure of SK channels.

Academic Significance and Societal Importance of the Research Achievements

本研究により、病的心における致死的不整脈に関する新たな機序、つまりは病的心における致死的不整脈には、従来心室筋での機能が不明確であったSKチャネルの活性化が関与しており、このチャネルはCaMKIIによって機能・構造制御をうけているという機序があきらかとなった。この研究結果を発展させることにより、致死的不整脈の分子標的治療薬の開発に結び付くことが期待される。さらにSKチャネルの活性を未然に防ぐことに着目することで病的心の致死的不整脈に対する予防治療にも大きく寄与すると考える。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2019 2018

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Arrhythmogenic β-adrenergic signaling in cardiac hypertrophy: The role of small-conductance calcium-activated potassium channels via activation of CaMKII2019

    • Author(s)
      Kamada Rui、Yokoshiki Hisashi、Mitsuyama Hirofumi、Watanabe Masaya、Mizukami Kazuya、Tenma Taro、Takahashi Masayuki、Takada Shingo、Anzai Toshihisa
    • Journal Title

      European Journal of Pharmacology

      Volume: 844 Pages: 110-117

    • DOI

      10.1016/j.ejphar.2018.12.011

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small-conductance Ca2+-activated K+ channel activation deteriorates hypoxic ventricular arrhythmias via CaMKII in cardiac hypertrophy2018

    • Author(s)
      Tenma Taro、Mitsuyama Hirofumi、Watanabe Masaya、Kakutani Naoya、Otsuka Yutaro、Mizukami Kazuya、Kamada Rui、Takahashi Masayuki、Takada Shingo、Sabe Hisataka、Tsutsui Hiroyuki、Yokoshiki Hisashi
    • Journal Title

      American Journal of Physiology-Heart and Circulatory Physiology

      Volume: 315 Issue: 2 Pages: H262-H272

    • DOI

      10.1152/ajpheart.00636.2017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Small-conductance Ca2+-activated K+ channel blockade prevents hypoxia-induced ventricular arrhythmias through inhibition of Ca2+/Voltage uncoupling in hypertrophied hearts2019

    • Author(s)
      Masayuki Takahashi, Hisashi Yokoshiki, Hirofumi Mitsuyama, Masaya Watanabe, Taro Tenma, Rui Kamada, Hikaru Hagiwara, Yumi Takahashi
    • Organizer
      Heart Rhythm Society 40th Annual Scientific Sessions 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Small-conductance Ca2+-activated K+ channel blockade prevents hypoxia-induced ventricular arrhythmias through inhibition of Ca2+/Voltage uncoupling in hypertrophied hearts2019

    • Author(s)
      Masayuki Takahashi, Hisashi Yokoshiki, Hirofumi Mitsuyama, Masaya Watanabe, Taro Tenma, Rui Kamada, Hikaru Hagiwara, Yumi Takahashi, Toshihisa Anzai
    • Organizer
      第66回 日本不整脈心電学会学術大会
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi