A new mechanism of coronary spastic angina: Possible role of beta-arrestin
| Project/Area Number |
18K15875
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Hirosaki University |
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Principal Investigator |
Hanada Kenji 弘前大学, 医学研究科, 客員研究員 (90632993)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 冠攣縮性狭心症 / βアレスチン |
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| Outline of Final Research Achievements |
To elucidate the mechanism of coronary spastic angina, we focused on the role of beta-arrestin on vascular smooth muscle cells. The increase of intracellular calcium concentration in response to acetylcholine, an inducer of coronary spasm, was enhanced by beta-arrestin 1 knockdown (the concentration of intracellular calcium is commonly correlated with the strength of smooth muscle cell contraction). In contrast, overexpression of beta-arrestin 1 reduced the enhancement of intracellular calcium concentration in response to acetylcholine. Thus, beta-arrestin 1 may have inhibitory effect for coronary spasm.
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| Academic Significance and Societal Importance of the Research Achievements |
冠攣縮性狭心症は日本人に多い疾患で、典型的には朝方の安静時胸痛を特徴とし、時に若年性の突然死の原因となる。冠拡張薬の内服により症状が改善することが多いが、少なからず難治例も存在し、対症療法であるため、内服薬を中断すると再発する。また、病因も未だ解明されていない。今回、我々は冠攣縮性狭心症の発症機序にβアレスチンが関与している可能性を明らかにした。この疾患におけるβアレスチンの役割が解明されることによって、将来的には新薬の開発の一助となる可能性がある。
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Report
(4 results)
Research Products
(1 results)
