| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Recent studies show that prolonged carotid baroreflex activation produces sustained hypotension mediated by sympathoinhibition and subsequent inhibition of the renin-angiotensin system. An atheroma developed in the carotid sinus impairs the baroreflex sensitivity and leads to sustained excessive sympathetic nerve activation (SNA). However, the effects of carotid artery revascularization (CAR) on cardiovascular profiles have not been thoroughly examined. In this study, MIBG scintigraphy showed that the H/M ratio after CAR was significantly higher than that before CAR, suggesting the improvement of cardiac SNA. E/e’ significantly decreased after CAR. This result suggests that CAR reduced the left atrial pressure. This study showed that CAR improved the left ventricular diastolic function, which is partly mediated by modified cardiac sympathetic nerve activity.
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