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Assessment of hybrid therapy of endvascular therapy and transfusion of adipose-derived stem cell for critical limb ischemia

Research Project

Project/Area Number 18K15885
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionShinshu University

Principal Investigator

Ebisawa Soichiro  信州大学, 医学部附属病院, 講師(特定雇用) (50645439)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords重症虚血肢 / 再生医療 / 事務手続き中 / 動脈硬化
Outline of Final Research Achievements

When we started this investigation, we could not perform the transfusion of adipose-derived stem cell for patient with critical limb ischemia. Now, we are preparing this therapy by the system of advanced medicine with multi-facility.
Current situation around treatment of critical limb ischemia is still poor, epic strategy was still not established, that improve the long-term out come of the patient with critical limb ischemia. So, this investigation is still important for this field. In near future, we will perform this hybrid therapy for the patient with indication of endovascular therapy however the blood run-off is poor immediately after transfusion of adipose-derived stem cell therapy is available.

Academic Significance and Societal Importance of the Research Achievements

動脈硬化性疾患の一つである閉塞性動脈硬化症が進行すると重症虚血肢となり、下肢の切断が必要になることがある。こうなってしまうと従来の血管内治療や薬物療法では一時的に創傷治癒が得られても極めて再発率が高い状況となり、複数回の入院後には結局膝下切断をしないと救命できない状況に陥り得る。
一方、脂肪幹細胞移植による再生医療も効果の検証段階であり施行できる施設は少なく昨今の再生医療新法により今は施行が出来ない状態である。本研究により血管内治療+脂肪幹細胞移植のハイブリッド治療は重症虚血肢により大事な足を失う危機にある患者を救う画期的な治療として期待している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2021 2020

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (5 results)

  • [Journal Article] Association of the Prognosis of Ankle-brachial Index Improvement One Year Following Endovascular Therapy in Patients with Peripheral Artery Disease: Data from the I-PAD NAGANO Registry2021

    • Author(s)
      Senda Keisuke、Miura Takashi、Kato Tamon、Kanzaki Yusuke、Abe Naoyuki、Yokota Daisuke、Yanagisawa Takashi、Okina Yoshiteru、Wakabayashi Tadamasa、Oyama Yushi、Karube Kenichi、Itagaki Tadashi、Yoda Hidetsugu、Shoin Kyoko、Oguchi Yasutaka、Aizawa Katsuyuki、Suzuki Chihiro、Kuwahara Koichiro
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 13 Pages: 1999-2006

    • DOI

      10.2169/internalmedicine.6117-20

    • NAID

      130008060446

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-07-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful bailout of stent graft stuck in stent occlusion lesion.2021

    • Author(s)
      Kato T, Nagae A, Sakai T, Saigusa T, Ebisawa S, Kuwahara K
    • Journal Title

      Cardiovasc Interv Ther

      Volume: in press Issue: 4 Pages: 535-536

    • DOI

      10.1007/s12928-020-00695-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of nutritional index on long-term outcomes of elderly patients with coronary artery disease: sub-analysis of the SHINANO 5 year registry.2021

    • Author(s)
      Maruyama S, Ebisawa S, Miura T, Yui H, Kashiwagi D, Nagae A, Sakai T, Kato T, Saigusa T, Okada A, Motoki H, Kuwahara K.
    • Journal Title

      Heart Vessels

      Volume: 36 Issue: 1 Pages: 7-13

    • DOI

      10.1007/s00380-020-01659-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hallucal thenar index: A new index to detect peripheral arterial disease using laser speckle flowgraphy2020

    • Author(s)
      Tsunekawa Kazuhiro、Nagai Fumio、Kato Tamon、Takashimizu Ikkei、Yanagisawa Daisuke、Yuzuriha Shunsuke
    • Journal Title

      Vascular

      Volume: 29 Issue: 1 Pages: 100-107

    • DOI

      10.1177/1708538120938935

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Limb-Based Patency After Surgical vs Endovascular Revascularization in Patients with Chronic Limb-Threatening Ischemia2020

    • Author(s)
      Utsunomiya Makoto、Takahara Mitsuyoshi、Iida Osamu、Soga Yoshimitsu、Hata Yosuke、Shiraki Tatsuya、Nagae Ayumu、Kato Tamon、Kobayashi Norihiro、Suematsu Nobuhiro、Tasaki Junichi、Horie Kazunori、Uchida Daiki、Kodama Akio、Azuma Nobuyoshi、Nakamura Masato
    • Journal Title

      Journal of Endovascular Therapy

      Volume: 27 Issue: 4 Pages: 584-594

    • DOI

      10.1177/1526602820923388

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] Impact of Residual SYNTAX Score of Coronary Artery Disease in Patients with Peripheral Arterial Disease after Endovascular Treatment in I-PAD-Registry.2021

    • Author(s)
      Kanzaki Y, Miura T, Kato T, Oyama Y, Yokota D, Senda K, OkinaY, Hoshizume N, Karube K, Itagaki T, Nomi H, Maruyama S, Nagae A, Sakai T, Saigusa T, Ebisawa S, Motoki H, Kuwahara K
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The Impact of hyperuricemia on all patients and low-BMI patients after endovascular treatments: From I-PAD Registry.2020

    • Author(s)
      Nagae A, Miura T, Kato T, Kanzaki Y, Abe N, Yokota D, Yanagisawa T, Senda K, Ide S, Takamatsu T, Inoue M, Yui H, Maruyama S, Kashiwagi D, Sakai T, Saigusa T, Ebisawa S, Okada A, Motoki H, Kuwahara K
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Association Between Statin Therapy and Body Mass Index After Undergoing Endovascular Treatment : Insight from I-PAD Study.2020

    • Author(s)
      Sakai T, Miura T, Kato K, Kanzaki Y, Abe N, Yokota D, Yanagisawa T, Senda K, Okina Y, Wakabayashi T, Oyama Y, Karube K, Itagaki T, Ide S, Inoue M, Takamatsu T, Kanai M, Yui H, Maruyama S, Kashiwagi D, Nagae A, Ebisawa S. Okada A, Motoki H, Kuwahara K
    • Organizer
      第84回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Association of Statin Therapy and Body Mass Index After Undergoing Endovascular Treatment : Insight from IPAD Study.2020

    • Author(s)
      酒井貴弘、三浦 崇、加藤太門、阿部直之、横田大介、井出翔吾、井上未奈美、高松利文、金井将史、由井寿典、丸山周作、柏木大輔、永江 歩、三枝達也、海老澤聡一朗、岡田綾子、元木博彦、桑原宏一郎
    • Organizer
      第29回日本心血管インターベンション治療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Is polypharmacy worsen prognosis of patients with peripheral artery disease? : From 3 years I-PAD NAGANO registry.2020

    • Author(s)
      井上未奈美、三浦 崇、加藤太門、神崎佑介、阿部直之、横田大介、柳澤 聖、千田啓介、翁 佳輝、井出翔吾、高松利文、由井寿典、丸山周作、柏木大輔、永江 歩、酒井貴弘、三枝達也、海老澤聡一朗、岡田綾子、桑原宏一郎
    • Organizer
      第29回日本心血管インターベンション治療学会
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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