| Project/Area Number |
18K15905
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HDL機能 / ApoA1 / 動脈硬化 / 予後 / マイクロRNA / マクロファージ / バイオマーカー / 冠動脈疾患 / micro RNA / HDL |
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| Outline of Final Research Achievements |
Despite an established prognostic significance of low high-density cholesterol (HDL)level in the context of atherosclerotic cardiovascular disease, recent failure of clinical trials of HDL raising drugs, such as CETP inhibitors and niacin, have caused less enthusiasm regarding its clinical and mechanistic exploration. However, since the functionality of HDL has been suggested to be further significant compared to its amount (serum concentration), we identified micro RNA (miRNA) specifically on HDL of patients underwent percutaneous coronary intervention (PCI) and performed their unbiased screening, which might have an impact on occurrence of cardiovascular mortality. Consequently, we identified 529 miRNAs in total. Among those,125 miRNAs were different more than 50%. Then, Mir-1914-3p, which has never been reported in association with cardiovascular disease, was identified as a potential prognostic marker or a therapeutic target for atherosclerotic cardiovascular disease.
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| Academic Significance and Societal Importance of the Research Achievements |
HDL(high density lipoprotein)は、その低値が動脈硬化リスクであることがエビデンスとして確立されているものの、LDL(low density lipoprotein)や中性脂肪に比べ、冠動脈疾患や脳血管疾患など動脈硬化性疾患の治療標的としての地位は高くない。本研究ではそのHDLの機能、ひいては予後にも影響する可能性のある、HDL上のmiRNAをスクリーニングし、これまで全く報告されていない新たなmiRNA、Mir-1914-3pを見出した。HDL機能をコントロール因子は未だに見出されておらず、今回の発見が新たな知見を加える可能性がある。
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