Role of anti-aging factor in cellular senescence and physical activity in chronic obstructive pulmonary disease

• Project/Area Number: 18K15916
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Tohoku University
• Principal Investigator: Onodera Katsuhiro 東北大学, 医学系研究科, 非常勤講師 (80814855)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 身体活動性 / COPD / 抗老化因子 / 急性増悪 / 細部老化 / GDF11 / 細胞老化

Outline of Final Research Achievements

Cellular senescence is known to be associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). I investigated the relationship between an anti-aging factor, Growth differentiation factor 11 (GDF11) and physical activity in COPD patients. Patients who maintained their plasma level of GDF11 showed higher physical activity and less frequent the acute deterioration of COPD symptoms. GDF11 could be a useful biomarker that reflects the physical activity in COPD.

Academic Significance and Societal Importance of the Research Achievements

COPD患者において身体活動性の低下はその後の寿命に最も影響を及ぼすことが知られている。抗老化因子と考えられているGDF11とCOPDにおける細胞老化、身体活動性の関係を解明することで、COPD患者の身体活動性の指標とできる可能性がある。一定期間にGDF11量が低下した患者に対して薬物治療やリハビリなどを行うことにより、身体活動性の低下を抑制し、COPD患者の予後の改善につなげられる可能性がある。

Research Products

• [Journal Article] Longitudinal Relationship Between Growth Differentiation Factor 11 and Physical Activity in Chronic Obstructive Pulmonary Disease (2021)
  • Author(s): Tanaka Rie、Koarai Akira、Yamada Mitsuhiro、Fujino Naoya、Ichikawa Tomohiro、Numakura Tadahisa、Onodera Katsuhiro、Kyogoku Yorihiko、Tamada Tsutomu、Miura Motohiko、Minakata Yoshiaki、Ichinose Masakazu、Sugiura Hisatoshi
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: Volume 16 Pages: 999-1006
  • DOI: 10.2147/copd.s301690
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Longitudinal relationship between growth differentiation factor 11 and physical activity in chronic obstructive pulmonary disease (2021)
  • Author(s): Rie Tanaka, Akira Koarai, Mitsuhiro Yamada, Naoya Fujino, Tomohiro Ichikawa, Tadahisa Numakura, Katushiro Onodera, Yorihiko Kyogoku, Tsutomu Tamada, Motohiko Miura, Yoshiaki Minakata, Masakazu Ichinose, HIsatoshi Sugiura
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: -
  • Peer Reviewed
• [Journal Article] Nitrosative stress in patients with asthma?chronic obstructive pulmonary disease overlap (2019)
  • Author(s): Kyogoku Yorihiko、Sugiura Hisatoshi、Ichikawa Tomohiro、Numakura Tadahisa、Koarai Akira、Yamada Mitsuhiro、Fujino Naoya、Tojo Yutaka、Onodera Katsuhiro、Tanaka Rie、Sato Kei、Sano Hirohito、Yamanaka Shun、Itakura Koji、Mitsune Ayumi、Tamada Tsutomu、Akaike Takaaki、Ichinose Masakazu
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 144 Issue: 4 Pages: 972-983
  • DOI: 10.1016/j.jaci.2019.04.023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease (2018)
  • Author(s): Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose
  • Journal Title: Int J Chron Obstruct Pulmon Dis. Volume: 13 Pages: 1333-1342
  • DOI: 10.2147/copd.s157035
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 最先端研究紹介(第2回) COPDにおける老化抑制因子Growth differentiation factor 11(GDF11)の関与に関する研究(解説) (2018)
  • Author(s): 小野寺 克洋, 杉浦 久敏, 山田 充啓, 一ノ瀬 正和
  • Journal Title: 分子呼吸器病 Volume: 22 Pages: 70-72
  • Peer Reviewed