Role of anti-aging factor in cellular senescence and physical activity in chronic obstructive pulmonary disease
| Project/Area Number |
18K15916
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 身体活動性 / COPD / 抗老化因子 / 急性増悪 / 細部老化 / GDF11 / 細胞老化 |
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| Outline of Final Research Achievements |
Cellular senescence is known to be associated with the pathogenesis of chronic obstructive pulmonary disease (COPD). I investigated the relationship between an anti-aging factor, Growth differentiation factor 11 (GDF11) and physical activity in COPD patients. Patients who maintained their plasma level of GDF11 showed higher physical activity and less frequent the acute deterioration of COPD symptoms. GDF11 could be a useful biomarker that reflects the physical activity in COPD.
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| Academic Significance and Societal Importance of the Research Achievements |
COPD患者において身体活動性の低下はその後の寿命に最も影響を及ぼすことが知られている。抗老化因子と考えられているGDF11とCOPDにおける細胞老化、身体活動性の関係を解明することで、COPD患者の身体活動性の指標とできる可能性がある。一定期間にGDF11量が低下した患者に対して薬物治療やリハビリなどを行うことにより、身体活動性の低下を抑制し、COPD患者の予後の改善につなげられる可能性がある。
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Report
(5 results)
Research Products
(5 results)
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[Journal Article] Longitudinal relationship between growth differentiation factor 11 and physical activity in chronic obstructive pulmonary disease2021
Author(s)
Rie Tanaka, Akira Koarai, Mitsuhiro Yamada, Naoya Fujino, Tomohiro Ichikawa, Tadahisa Numakura, Katushiro Onodera, Yorihiko Kyogoku, Tsutomu Tamada, Motohiko Miura, Yoshiaki Minakata, Masakazu Ichinose, HIsatoshi Sugiura
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Journal Title
International Journal of Chronic Obstructive Pulmonary Disease
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease2018
Author(s)
Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose
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Journal Title
Int J Chron Obstruct Pulmon Dis.
Volume: 13
Pages: 1333-1342
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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