| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Acute Rapid Respiratory Distress Syndrome (ARDS) is a poor prognosis disease characterized by a rapid inflammatory response to cytokine storms associated with pulmonary and systemic inflammation. However, the pathophysiology has not been clearly defined. In this study, we investigated the relationship between basophils and the pathogenesis of ARDS.
IL4 has been known to be a cytokine associated with ARDS. In our study, we found that removal of basophils aggravated or delayed the pathogenesis of ARDS as well as in IL4-deficient mice.
Network analysis by FACS and single-cell analysis suggested that IL4 produced by basophils is involved in macrophages and neutrophils.
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