Development of immunological test using recombinant antigen for diagnosis of bird-related hypersensitivity pneumonitis.
| Project/Area Number |
18K15920
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHIRAI TSUYOSHI 東京医科歯科大学, 東京医科歯科大学病院, 助教 (00796617)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2020: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2019: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 過敏性肺炎 / アレルギー性胞隔炎 / 特異抗体 / 鳥抗原 / 鳥関連過敏性肺炎 / 抗原タンパク / ハト |
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| Outline of Final Research Achievements |
Bird-related hypersensitivity pneumonitis (BRHP), the most common type of hypersensitivity pneumonitis (HP) in Japan, could be caused by inhalation of bird dropping or feather/down. There was no standardized test for evaluating the disease-specific immune response of BRHP. As a results of our research, serum specific-IgG antibody against pigeon and budgerigar antigen with ImmunoCAP was approved by Japanese insurance in 2021.
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| Academic Significance and Societal Importance of the Research Achievements |
間質性肺炎は、根治療法がない難治性の病気であり、原因が特定できない場合が多いが、一部は鳥フンや羽毛の吸入によるアレルギーが原因となる。アレルギーが原因の場合を過敏性肺炎と呼び、原因物質の除去・回避により病気の進行が抑えられる。これまで鳥に対するアレルギーの有無を評価する検査方法は存在しなかったが、我々の検討の結果、鳥抗原に対するIgG抗体の測定が保険収載され、全国の病院で実施が可能となった。
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Report
(5 results)
Research Products
(12 results)
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[Journal Article] Predictors associated with clinical improvement of SARS-CoV-2 pneumonia2021
Author(s)
Mitsumura Takahiro、Okamoto Tsukasa、Shirai Tsuyoshi、Iijima Yuki、Sakakibara Rie、Honda Takayuki、Ishizuka Masahiro、Aiboshi Junichi、Tateishi Tomoya、Tamaoka Meiyo、Shigemitsu Hidenobu、Arai Hirokuni、Otomo Yasuhiro、Tohda Shuji、Anzai Tatsuhiko、Takahashi Kunihiko、Yasuda Shinsuke、Miyazaki Yasunari
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Journal Title
Journal of Infection and Chemotherapy
Volume: 27
Issue: 6
Pages: 857-863
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Screening and diagnosis of acute and chronic bird-related hypersensitivity pneumonitis by serum IgG and IgA antibodies to bird antigens with ImmunoCAP®2021
Author(s)
Shirai T, Tanino Y, Nikaido T, Takaku Y, Hashimoto S, Taguchi Y, Baba T, Ogura T, Kataoka K, Nakayama M, Yamada Y, Matsushima S, Nakayama S, Miyazaki Y
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Journal Title
Allergology International
Volume: 70
Issue: 2
Pages: 208-214
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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