| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We retrospectively analyzed 205 lung adenocarcinoma patients treated at Kyushu University Hospital. MOB1 expression in tumor cells of surgical specimens was evaluated by immunohistochemistry. Expression of MOB1 was classified as high in 105 of the 205 tumor specimens, and such high expression was significantly associated with poor disease-free survival. Among the various clinicopathologic parameters examined, high MOB1 expression was significantly associated only with intratumoral vascular invasion. Multivariate analysis also identified high MOB1 expression as a significant independent risk factor for disease-free survival. Invasive activity of cell lines in vitro was measured with a transwell assay and the invasiveness of H1299 cells was increased or attenuated by overexpression or knockdown of MOB1, respectively.
Our results suggest that MOB1 might promote early recurrence of adenocarcinoma by increasing vascular invasion by tumor cells.
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