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Studies on the annual change of biomarkers in severe asthmatics.

Research Project

Project/Area Number 18K15939
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionHokkaido University

Principal Investigator

Kimura Hirokazu  北海道大学, 大学病院, 医員 (90789330)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords難治性喘息 / バイオマーカー / 増悪 / 個別化治療 / 経年変化 / 喫煙 / 病型分類
Outline of Final Research Achievements

We conducted various analyzes using data from a prospective 6-year refractory asthma cohort study, including smokers. In this study, we used the terms 'biomarker' as not only the molecules such as cytokines, but also the asthma associated indices such as respiratory function or exacerbation.
We focused on the annual changes in several indices. To date, we obtained no significant results for annual change of cytokine in blood or sputum. We will continue to analyze. Regarding respiratory function, we are currently analyzing, and we will present the result in this year. In 3-year exacerbation study, the group with consistently frequent exacerbators was associated with eosinophil and fractional exhaled nitric oxide, so called 'Th2 markers'. We are trying to identify the phenotype using cut-off value, and now we are preparing a paper.

Academic Significance and Societal Importance of the Research Achievements

本研究では喫煙者を含む集団を対象として、より実臨床を反映している質の高いコホートである。現在の喘息治療における課題は、治療が難しい「難治性喘息」の患者を、いかに早期に見つけ出して介入するか、というところにあると考えられる。こういった意味では、本研究の結果から、将来の増悪リスクが高い患者群を見つけ出すことができるようになる可能性があり、そういった患者群に対してはより注意して治療介入を行うことができよう。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2019 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up2018

    • Author(s)
      Kimura H.、Konno S.、Makita H.、Taniguchi N.、Shimizu K.、Suzuki M.、Kimura H.、Goudarzi H.、Nakamaru Y.、Ono J.、Ohta S.、Izuhara K.、Ito Y.?M.、Wenzel S. E.、Nishimura M.、for the Hi-CARAT investigators
    • Journal Title

      Clinical & Experimental Allergy

      Volume: 48 Issue: 9 Pages: 1137-1146

    • DOI

      10.1111/cea.13170

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 重症喘息コホートにおける増悪状況とその関連因子についての検討2019

    • Author(s)
      木村孔一、今野哲、牧田比呂仁、谷口菜津子、木村裕樹、清水薫子、鈴木雅、西村正治、Hi-CARAT Investigators
    • Organizer
      第116回日本内科学会総会・講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Determination of cut-off value of Th2 markers for prediction of future exacerbation in severe asthma: an analysis from the Hokkaido Severe Asthma Cohort Study2019

    • Author(s)
      Hirokazu Kimura, Hironi Makita, Natsuko Taniguchi, Hiroki Kimura, Kaoruko Shimizu, Masaru Suzuki, Masaharu Nishimura, Satoshi Konno, and for the Hi-CARAT investigators
    • Organizer
      American Thoracic Society 2019 International Conference
    • Related Report
      2019 Annual Research Report
  • [Presentation] 重症喘息患者における増悪状況とTh2マーカー陽性数の検討2019

    • Author(s)
      木村孔一、牧田比呂仁、谷口菜津子、木村裕樹、清水薫子、鈴木雅、武井望、松本宗大、Houman Goudarzi、西村正治、今野哲
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 難治性喘息における増悪頻度及びその予測因子の検討2018

    • Author(s)
      木村孔一, 今野哲, 牧田比呂仁, 谷口菜津子, 清水薫子, 鈴木雅, 小野純也, 出原賢治, 西村正治
    • Organizer
      第27回 Pneumo Forum
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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