Elucidation of molecular expression in patients with idiopathic interstitial pneumonia using multidisciplinary proteomic analysis and its clinical application

• Project/Area Number: 18K15947
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Hozumi Hironao 浜松医科大学, 医学部附属病院, 助教 (40771457)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 特発性肺線維症 / プロテオミクス / バイオマーカー / 特発性間質性肺炎 / グライコプロテオミクス

Outline of Final Research Achievements

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease with a poor prognosis characterized by irreversible fibrosis of the lung. However, the clinical course of patients with IPF is variable and unpredictable. A biomarker that can predict disease progression and poor prognosis would help to determine the treatment strategy at an appropriate time. In this study, we explored biomarkers associated with disease progression using comprehensive proteomic analyses of　specimens from patients with IPF, and found several promising molecules among a number of candidates. In particular, cold-inducible RNA-binding protein (CIRBP) was highly expressed in the blood and lung fibrotic tissues of patients with IPF and was validated in two independent IPF cohorts to be a promising biomarker for predicting disease progression and mortality.

Academic Significance and Societal Importance of the Research Achievements

IPF患者の臨床経過は多様であり、進行が早く予後不良な患者もいれば、無治療でも進行に乏しい患者もいる。抗線維化薬や肺移植は重要な治療選択肢であるが、有害事象・合併症や生活の質の低下、医療コスト等が問題となるため、治療介入決定には重症度や疾患進行速度を考慮する必要がある。血清CIRBPの測定は、ハイリスクなIPF患者の早期同定によって治療方針の早期決定に役立ち、予後の改善に貢献できるものと考えられる。またIPF肺の線維化組織におけるCIRBPの高発現は、CIRBPとIPFの病態との関連性が示唆され、CIRBPが将来的な治療標的となる可能性も考えられた。

Research Products

• [Journal Article] Clinical Significance of Interstitial Lung Disease and Its Acute Exacerbation in Microscopic Polyangiitis (2021)
  • Author(s): Hozumi H, Kono M, Hasegawa H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Yokomura K, Nakamura H, Suda T.
  • Journal Title: Chest . Volume: S0012-3692(21) Issue: 6 Pages: 00259-2
  • DOI: 10.1016/j.chest.2021.01.083
  • Peer Reviewed
• [Journal Article] Risk Factors for Pneumonia and Death in Adult Patients With Seasonal Influenza and Establishment of Prediction Scores: A Population-Based Study (2021)
  • Author(s): Miyashita Koichi、Nakatani Eiji、Hozumi Hironao、Sato Yoko、Miyachi Yoshiki、Suda Takafumi
  • Journal Title: Open Forum Infectious Diseases Volume: 8 Issue: 3
  • DOI: 10.1093/ofid/ofab068
  • Peer Reviewed / Open Access
• [Journal Article] Conventional type 2 lung dendritic cells are potent inducers of follicular helper T cells in the asthmatic lung (2021)
  • Author(s): Sakurai S, Furuhashi K, Horiguchi R, Nihashi F, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T,
  • Journal Title: Allergology International Volume: - Issue: 3 Pages: 351-359
  • DOI: 10.1016/j.alit.2021.01.008
  • NAID: 130008064053
  • Peer Reviewed / Open Access
• [Journal Article] Cluster analysis-based clinical phenotypes of idiopathic interstitial pneumonias: associations with acute exacerbation and overall survival (2021)
  • Author(s): Aoshima Y, Karayama M, Horiike Y, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: BMC Pulm Med. Volume: 21(1) Issue: 1 Pages: 63-63
  • DOI: 10.1186/s12890-021-01428-3
  • Peer Reviewed / Open Access
• [Journal Article] Predictors for bronchoalveolar lavage recovery failure in diffuse parenchymal lung disease (2021)
  • Author(s): Koda K, Hozumi H, Yasui H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Sci Rep . Volume: 11(1) Issue: 1 Pages: 1682-1682
  • DOI: 10.1038/s41598-021-81313-5
  • Peer Reviewed / Open Access
• [Journal Article] Pneumothorax in Patients with Idiopathic Pleuroparenchymal Fibroelastosis: Incidence, Clinical Features, and Risk Factors (2021)
  • Author(s): Kono Masato、Nakamura Yutaro、Enomoto Yasunori、Yasui Hideki、Hozumi Hironao、Karayama Masato、Suzuki Yuzo、Furuhashi Kazuki、Miki Yoshihiro、Hashimoto Dai、Fujisawa Tomoyuki、Enomoto Noriyuki、Inui Naoki、Suda Takafumi
  • Journal Title: Respiration Volume: 100 Issue: 1 Pages: 19-26
  • DOI: 10.1159/000511965
  • Peer Reviewed
• [Journal Article] Quality of dying and death in patients with interstitial lung disease compared with lung cancer: an observational study (2020)
  • Author(s): Koyauchi Takafumi、Suzuki Yuzo、Sato Kazuki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Yokomura Koshi、Imokawa Shiro、Nakamura Hidenori、Morita Tatsuya、Suda Takafumi
  • Journal Title: Thorax Volume: 76 Issue: 3 Pages: 248-255
  • DOI: 10.1136/thoraxjnl-2020-215917
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of Immune-Related Interstitial Lung Disease in Patients With NSCLC Treated with Immune Checkpoint Inhibitors: A Multicenter Prospective Study (2020)
  • Author(s): Suzuki Y, Karayama M, Uto T, Fujii M, Matsui T, Asada K, Kusagaya H, Kato M, Matsuda H, Matsuura S, Toyoshima M, Mori K, Ito Y, Koyauchi T, Yasui H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Suda T.
  • Journal Title: Journal of Thoracic Oncology Volume: S1556 Issue: 8 Pages: 1317-1327
  • DOI: 10.1016/j.jtho.2020.04.002
  • Peer Reviewed
• [Journal Article] Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer (2020)
  • Author(s): Karayama M.、Masuda J.、Mori K.、Yasui H.、Hozumi H.、Suzuki Y.、Furuhashi K.、Fujisawa T.、Enomoto N.、Nakamura Y.、Inui N.、Suda T.、Maekawa M.、Sugimura H.、Takada A.
  • Journal Title: Clinical and Translational Oncology Volume: 23 Issue: 2 Pages: 418-423
  • DOI: 10.1007/s12094-020-02421-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Palliative Care for Idiopathic Pulmonary Fibrosis Patients: Pulmonary Physicians' View (2020)
  • Author(s): Akiyama N, Fujisawa T, Morita T, Mori K, Yasui H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: J Pain Symptom Manage. Volume: 60(5) Issue: 5 Pages: 933-940
  • DOI: 10.1016/j.jpainsymman.2020.06.012
  • NAID: 120007173433
  • Peer Reviewed
• [Journal Article] Acute exacerbation of unclassifiable idiopathic interstitial pneumonia: comparison with idiopathic pulmonary fibrosis (2020)
  • Author(s): Enomoto N, Naoi H, Aono Y, Katsumata M, Horiike Y, Yasui H, Karayama M, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Ther Adv Respir Dis. Volume: 14
  • DOI: 10.1177/1753466620935774
  • Peer Reviewed / Open Access
• [Journal Article] Pneumothorax in connective tissue disease-associated interstitial lung disease. (2020)
  • Author(s): Nishimoto K, Fujisawa T, Yoshimura K, Enomoto Y, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Sumikawa H, Johkoh T, Suda T.
  • Journal Title: PLoS One. Volume: 15(7) Issue: 7 Pages: e0235624-e0235624
  • DOI: 10.1371/journal.pone.0235624
  • Peer Reviewed / Open Access
• [Journal Article] Development of a novel T cell‐oriented vaccine using CTL/Th‐hybrid epitope long peptide and biodegradable microparticles, against an intracellular bacterium (2020)
  • Author(s): Tanaka Kazuki、Enomoto Noriyuki, et al.
  • Journal Title: Microbiology and Immunology Volume: 64 Issue: 10 Pages: 666-678
  • DOI: 10.1111/1348-0421.12836
  • Peer Reviewed
• [Journal Article] Erlotinib and bevacizumab in elderly patients ?75?years old with non-small cell lung cancer harboring epidermal growth factor receptor mutations (2020)
  • Author(s): Aoshima Yoichiro、Karayama Masato、Inui Naoki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Mikamo Masashi、Matsuura Shun、Kusagaya Hideki、Kaida Yusuke、Uto Tomohiro、Hashimoto Dai、Matsui Takashi、Asada Kazuhiro、Suda Takafumi
  • Journal Title: Investigational New Drugs Volume: 39 Issue: 1 Pages: 210-216
  • DOI: 10.1007/s10637-020-00988-1
  • NAID: 120007143503
  • Peer Reviewed / Open Access
• [Journal Article] Disease course and prognosis of pleuroparenchymal fibroelastosis compared with idiopathic pulmonary fibrosis (2020)
  • Author(s): Suzuki Yuzo、Fujisawa Tomoyuki、Sumikawa Hiromitsu、Tanaka Tomonori、Sugimoto Chikatoshi、Kono Masato、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respiratory Medicine Volume: 171 Pages: 106078-106078
  • DOI: 10.1016/j.rmed.2020.106078
  • NAID: 120007165670
  • Peer Reviewed
• [Journal Article] Prognostic significance of forced vital capacity decline prior to and following antifibrotic therapy in idiopathic pulmonary fibrosis (2020)
  • Author(s): Aono Yuya、Nakamura Yutaro, et al.
  • Journal Title: Therapeutic Advances in Respiratory Disease Volume: 14
  • DOI: 10.1177/1753466620953783
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of Programmed Death Ligand 1 (PD-L1) Gene Amplification and Response to Nivolumab Monotherapy in Non-small Cell Lung Cancer (2020)
  • Author(s): Inoue Y, Yoshimura K, Nishimoto K, Inui N, Karayama M, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Asada K, Uto T, Fujii M, Matsui T, Matsuura S, Hashimoto D, Toyoshima M, Kusagaya H, Matsuda H, Inami N, Kaida Y, Niwa M, Ito Y, Sugimura H, Suda T.
  • Journal Title: JAMA Netw Open. Volume: 3(9) Issue: 9 Pages: e2011818-e2011818
  • DOI: 10.1001/jamanetworkopen.2020.11818
  • Peer Reviewed / Open Access
• [Journal Article] Cause of mortality and sarcopenia in patients with idiopathic pulmonary fibrosis receiving antifibrotic therapy (2020)
  • Author(s): Suzuki Yuzo、Aono Yuya、Kono Masato、Hasegawa Hirotsugu、Yokomura Koushi、Naoi Hyogo、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respirology Volume: 26 Issue: 2 Pages: 171-179
  • DOI: 10.1111/resp.13943
  • NAID: 120007159867
  • Peer Reviewed
• [Journal Article] Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium. (2020)
  • Author(s): Kamiya Y, Fujisawa T, Katsumata M, Yasui H, Suzuki Y, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Setou M, Ito M, Suzuki T, Ikegami K, Suda T.
  • Journal Title: Respir Res. Volume: 21 Issue: 1 Pages: 282-282
  • DOI: 10.1186/s12931-020-01555-1
  • Peer Reviewed / Open Access
• [Journal Article] Clinical, radiological, and pathological evaluation of "NSIP with OP overlap" pattern compared with NSIP in patients with idiopathic interstitial pneumonias (2020)
  • Author(s): Enomoto N, Sumikawa H, Sugiura H, Kitani M, Tanaka T, Hozumi H, Fujisawa T, Suda T.
  • Journal Title: Respiratory Medicine Volume: 174 Pages: 106201-106201
  • DOI: 10.1016/j.rmed.2020.106201
  • NAID: 120007181707
  • Peer Reviewed
• [Journal Article] Prednisolone and tacrolimus versus prednisolone and cyclosporin A to treat polymyositis/dermatomyositis‐associated ILD : A randomized, open‐label trial (2020)
  • Author(s): Fujisawa Tomoyuki、Hozumi Hironao、Kamiya Yosuke、Kaida Yusuke、Akamatsu Taisuke、Kusagaya Hideki、Satake Yasuomi、Mori Kazutak、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Respirology Volume: 26 Issue: 4 Pages: 370-377
  • DOI: 10.1111/resp.13978
  • Peer Reviewed
• [Journal Article] Predictors of acute exacerbation in biopsy-proven idiopathic pulmonary fibrosis. (2020)
  • Author(s): Kishaba T, Hozumi H, Fujisawa T, Nei Y, Enomoto N, Sugiura H, Kitani M, Suda T.
  • Journal Title: Respiratory Investigation Volume: - Issue: 3 Pages: 177-184
  • DOI: 10.1016/j.resinv.2020.02.004
  • NAID: 120007097009
  • Peer Reviewed
• [Journal Article] Intravoxel incoherent motion magnetic resonance imaging for predicting the long-term efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer. (2020)
  • Author(s): Karayama M, Yoshizawa N, Sugiyama M, Mori K, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Inui N, Goshima S, Suda T, Takehara Y.
  • Journal Title: Lung Cancer Volume: 143 Pages: 47-54
  • DOI: 10.1016/j.lungcan.2020.03.013
  • NAID: 120007041512
  • Peer Reviewed
• [Journal Article] Pulse oximetric saturation to fraction of inspired oxygen (SpO2/FIO2) ratio 24 hours after high-flow nasal cannula (HFNC) initiation is a good predictor of HFNC therapy in patients with acute exacerbation of interstitial lung disease. (2020)
  • Author(s): Koyauchi T, Yasui H, Enomoto N, Hasegawa H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Fujisawa T, Nakamura Y, Inui N, Yokomura K, Suda T.
  • Journal Title: Therapeutic Advances in Respiratory Disease Volume: 14
  • DOI: 10.1177/1753466620906327
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of serum S100 calcium-binding protein A4 in idiopathic pulmonary fibrosis. (2019)
  • Author(s): Akiyama N, Hozumi H, Isayama T, Okada J, Sugiura K, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respirology Volume: 0 Issue: 7 Pages: 0-0
  • DOI: 10.1111/resp.13707
  • NAID: 120007097006
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Macrophage Mannose Receptor CD206 Predicts Prognosis in Community-acquired Pneumonia. (2019)
  • Author(s): Tsuchiya K, Suzuki Y, Yoshimura K, Yasui H, Karayama M, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Yokomura K, Suda T.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1
  • DOI: 10.1038/s41598-020-58958-9
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic factors for primary Sjögren's syndrome-associated interstitial lung diseases. (2019)
  • Author(s): Kamiya Y, Fujisawa T, Kono M, Nakamura H, Yokomura K, Koshimizu N, Toyoshima M, Imokawa S, Sumikawa H, Johkoh T, Yasui H, Hozumi H, Suzuki Y, Karayama M, Furuhashi K, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Respiratory Medicine Volume: 159 Pages: 105811-105811
  • DOI: 10.1016/j.rmed.2019.105811
  • Peer Reviewed
• [Journal Article] Effect of PD-1 inhibitor on exhaled nitric oxide and pulmonary function in non-small cell lung cancer patients with and without COPD. (2019)
  • Author(s): Suzuki Y, Inui N, Karayama M, Imokawa S, Yamada T, Yokomura K, Asada K, Kusagaya H, Kaida Y, Matsuda H, Koshimizu N, Toyoshima M, Masuda M, Hayakawa H, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Suda T.
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: 14 Pages: 1867-1877
  • DOI: 10.2147/copd.s214610
  • Peer Reviewed / Open Access
• [Journal Article] Once-daily fluticasone furoate/vilanterol combination versus twice-daily budesonide/formoterol combination in the treatment of controlled stable asthma: a randomized crossover trial. (2019)
  • Author(s): Furuhashi K, Fujisawa T, Hashimoto D, Kamiya Y, Yasui H, Karayama M, Suzuki Y, Hozumi H, Enomoto N, Nakamura Y, Inui N, Suda T.
  • Journal Title: Journal of Asthma and Allergy Volume: 12 Pages: 253-261
  • DOI: 10.2147/jaa.s223093
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of an early marginal decline in forced vital capacity in idiopathic pulmonary fibrosis patients treated with pirfenidone. (2019)
  • Author(s): Kono M, Nakamura Y, Enomoto N, Saito G, Koyanagi Y, Miyashita K, Tsutsumi A, Kobayashi T, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Miki Y, Hashimoto D, Fujisawa T, Inui N, Suda T, Nakamura H.
  • Journal Title: Respir Investig. Volume: 57 Issue: 6 Pages: 552-560
  • DOI: 10.1016/j.resinv.2019.07.003
  • Peer Reviewed / Open Access
• [Journal Article] Body composition changes successfully classify prognosis in patients with mycobacterium avium complex lung disease. (2019)
  • Author(s): Akahori D, Suzuki Y, Yokomura K, Shirai M, Yasui H, Hozumi H, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Hayakawa H, Suda T.
  • Journal Title: Journal of Infection Volume: 79 Issue: 4 Pages: 341-348
  • DOI: 10.1016/j.jinf.2019.07.014
  • Peer Reviewed
• [Journal Article] Analysis of serum adiponectin and leptin in patients with acute exacerbation of idiopathic pulmonary fibrosis. (2019)
  • Author(s): Enomoto N, Oyama Y, Yasui H, Karayama M, Hozumi H, Suzuki Y, Kono M, Furuhashi K, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 10484-10484
  • DOI: 10.1038/s41598-019-46990-3
  • Peer Reviewed / Open Access
• [Journal Article] Clinical features of three-dimensional computed tomography-based radiologic phenotypes of chronic obstructive pulmonary disease. (2019)
  • Author(s): Karayama M, Inui N, Yasui H, Kono M, Hozumi H, Suzuki Y, Furuhashi K, Hashimoto D, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: International Journal of Chronic Obstructive Pulmonary Disease Volume: 14 Pages: 1333-1342
  • DOI: 10.2147/copd.s207267
  • Peer Reviewed / Open Access
• [Journal Article] Frequency and clinical relevance of anti-cyclic citrullinated peptide antibody in idiopathic interstitial pneumonias (2019)
  • Author(s): Katsumata M, Hozumi H, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Suda T.
  • Journal Title: Respir Med Volume: 154 Pages: 102-108
  • DOI: 10.1016/j.rmed.2019.06.016
  • Peer Reviewed
• [Journal Article] Successful classification of macrophage-mannose receptor CD206 in severity of anti-MDA5 antibody positive dermatomyositis associated ILD (2019)
  • Author(s): Horiike Yasuoki, Suzuki Yuzo, Fujisawa Tomoyuki, Yasui Hideki, Karayama, Masato, Hozumi Hironao, Furuhashi Kazuki, Enomoto Noriyuki, Nakamura Yutaro, Inui Naoki, Ogawa Noriyoshi, Suda Takafumi
  • Journal Title: Rheumatology Volume: 印刷中 Issue: 12 Pages: 2143-2152
  • DOI: 10.1093/rheumatology/kez185
  • Peer Reviewed
• [Journal Article] Physiological and morphological differences of airways between COPD and asthma?COPD overlap (2019)
  • Author(s): Karayama Masato、Inui Naoki、Yasui Hideki、Kono Masato、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Hashimoto Dai、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Watanabe Hiroshi、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 7818-7818
  • DOI: 10.1038/s41598-019-44345-6
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Serum Chitotriosidase Level in Anti-MDA5 Antibody?positive Dermatomyositis-associated Interstitial Lung Disease (2019)
  • Author(s): Fujisawa Tomoyuki、Hozumi Hironao、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: The Journal of Rheumatology Volume: 46 Issue: 8 Pages: 935-942
  • DOI: 10.3899/jrheum.180825
  • Peer Reviewed
• [Journal Article] Olanzapine-containing antiemetic therapy for the prevention of carboplatin-induced nausea and vomiting. (2019)
  • Author(s): Tanaka K, Inui N, Karayama M, Yasui H, Hozumi H, Suzuki Y, Furuhashi K, Fujisawa T, Enomoto N, Nakamura Y, Kusagaya H, Matsuura S, Uto T, Hashimoto D, Matsui T, Asada K, Suda T.
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 84 Issue: 1 Pages: 147-153
  • DOI: 10.1007/s00280-019-03868-5
  • Peer Reviewed
• [Journal Article] Nationwide cloud-based integrated database of idiopathic interstitial pneumonias for multidisciplinary discussion. (2019)
  • Author(s): Fujisawa T, Mori K, Mikamo M, Ohno T, Kataoka K, Sugimoto C, Kitamura H, Enomoto N, Egashira R, Sumikawa H, Iwasawa T, Matsushita S, Sugiura H, Hashisako M, Tanaka T, Terasaki Y, Kunugi S, Kitani M, Okuda R, Horiike Y, Enomoto Y, Yasui H, Hozumi H, Suzuki Y, Nakamura Y, Fukuoka J, Johkoh T, Kondoh Y, Ogura T,,, Suda T.
  • Journal Title: Eur Respir J. Volume: 3 Issue: 5 Pages: 1802243-1802243
  • DOI: 10.1183/13993003.02243-2018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Efficacy of corticosteroid and intravenous cyclophosphamide in acute exacerbation of idiopathic pulmonary fibrosis: A propensity score‐matched analysis (2019)
  • Author(s): Hozumi Hironao、Hasegawa Hirotsugu、Miyashita Koichi、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Hashimoto Dai、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Yokomura Koshi、Nakamura Hidenori、Suda Takafumi
  • Journal Title: Respirology Volume: 印刷中 Issue: 8 Pages: 792-798
  • DOI: 10.1111/resp.13506
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Switch maintenance therapy with S-1 after induction therapy with carboplatin and nanoparticle albumin-bound paclitaxel in advanced lung squamous cell carcinoma (2019)
  • Author(s): Akiyama Norimichi、Karayama Masato、Inui Naoki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inami Nao、Matsuura Shun、Kaida Yusuke、Uto Tomohiro、Matsui Takashi、Asada Kazuhiro、Matsuda Hiroyuki、Fujii Masato、Toyoshima Mikio、Suda Takafumi
  • Journal Title: Investigational New Drugs Volume: 印刷中 Issue: 3 Pages: 531-537
  • DOI: 10.1007/s10637-019-00747-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correlation of the modified Medical Research Council dyspnea scale with airway structure assessed by three-dimensional CT in patients with chronic obstructive pulmonary disease (2019)
  • Author(s): Yasui Hideki、Inui Naoki、Karayama Masato、Mori Kazutaka、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Watanabe Hiroshi、Suda Takafumi
  • Journal Title: Respiratory Medicine Volume: 146 Pages: 76-80
  • DOI: 10.1016/j.rmed.2018.11.020
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody?positive Polymyositis/dermatomyositis?associated Interstitial Lung Disease: A Propensity Score?matched Analysis (2019)
  • Author(s): Hozumi Hironao、Fujisawa Tomoyuki、Nakashima Ran、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Inui Naoki、Nakamura Yutaro、Mimori Tsuneyo、Suda Takafumi
  • Journal Title: The Journal of Rheumatology Volume: 印刷中 Issue: 5 Pages: 509-517
  • DOI: 10.3899/jrheum.180778
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Methotrexate-associated Lymphoproliferative Disorder with Diffuse Ground-Glass Opacities (2019)
  • Author(s): Tsuchiya Kazuo、Suzuki Yuzo、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Baba Satoshi、Suda Takafumi
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 199 Issue: 8 Pages: 1031-1033
  • DOI: 10.1164/rccm.201806-1115im
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An Acquired Epidermal Growth Factor Receptor T790M Mutation after the Addition of Bevacizumab to Preceding Erlotinib Monotherapy in a Lung Cancer Patient with Leptomeningeal Metastases (2018)
  • Author(s): Tsuchiya Kazuo、Karayama Masato、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Internal Medicine Volume: 57 Issue: 23 Pages: 3423-3427
  • DOI: 10.2169/internalmedicine.1062-18
  • NAID: 130007539653
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-12-01
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Anti-PL-7 Antisynthetase Syndrome with Eosinophilic Pleural Effusion (2018)
  • Author(s): Saito G, Kono M, Tsutsumi A, Koyanagi Y, Miyashita K, Kobayashi T, Hozumi H, Miki Y, Arai Y, Otsuki Y, Hashimoto D, Fujisawa T, Nakamura T, Suda T, Nakamura H.
  • Journal Title: Internal Medicine Volume: 57 Issue: 15 Pages: 2227-2232
  • DOI: 10.2169/internalmedicine.0302-17
  • NAID: 130007429162
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-08-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neurogenic Pulmonary Edema without Norepinephrine Elevation (2018)
  • Author(s): Yasui Hideki、Arima Hideyuki、Hozumi Hironao、Suda Takafumi
  • Journal Title: Internal Medicine Volume: 57 Issue: 14 Pages: 2097-2098
  • DOI: 10.2169/internalmedicine.9825-17
  • NAID: 130007404919
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2018-07-15
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differences in clinical features of acute exacerbation between connective tissue disease-associated interstitial pneumonia and idiopathic pulmonary fibrosis (2018)
  • Author(s): Enomoto Noriyuki、Oyama Yoshiyuki、Enomoto Yasunori、Yasui Hideki、Karayama Masato、Kono Masato、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: Chronic Respiratory Disease Volume: 16
  • DOI: 10.1177/1479972318809476
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis (2018)
  • Author(s): Suzuki Yuzo、Yoshimura Katsuhiro、Enomoto Yasunori、Yasui Hideki、Hozumi Hironao、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 14074-14074
  • DOI: 10.1038/s41598-018-32478-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-17A Attenuates IFN-λ Expression by Inducing Suppressor of Cytokine Signaling Expression in Airway Epithelium (2018)
  • Author(s): Niwa Mitsuru、Fujisawa Tomoyuki、Mori Kazutaka、Yamanaka Katsumasa、Yasui Hideki、Suzuki Yuzo、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suzuki Tetsuro、Maekawa Masato、Suda Takafumi
  • Journal Title: The Journal of Immunology Volume: 201 Issue: 8 Pages: 2392-2402
  • DOI: 10.4049/jimmunol.1800147
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prophylactic aprepitant is better than salvage for carboplatin-based chemotherapy: a propensity score-matched analysis (2018)
  • Author(s): Karayama Masato、Inui Naoki、Tanaka Kazuki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: Medical Oncology Volume: 35 Issue: 11 Pages: 139-139
  • DOI: 10.1007/s12032-018-1199-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis (2018)
  • Author(s): Suzuki Yuzo、Shirai Masahiro、Asada Kazuhiro、Yasui Hideki、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Shirai Toshihiro、Hayakawa Hiroshi、Suda Takafumi
  • Journal Title: Scientific Reports Volume: 8 Issue: 1 Pages: 13129-13129
  • DOI: 10.1038/s41598-018-31565-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Differences in airway structural changes assessed by 3-dimensional computed tomography in asthma and asthma?chronic obstructive pulmonary disease overlap (2018)
  • Author(s): Niwa Mitsuru、Fujisawa Tomoyuki、Karayama Masato、Furuhashi Kazuki、Mori Kazutaka、Hashimoto Dai、Yasui Hideki、Suzuki Yuzo、Hozumi Hironao、Enomoto Noriyuki、Nakamura Yutaro、Inui Naoki、Suda Takafumi
  • Journal Title: Annals of Allergy, Asthma & Immunology Volume: 121 Issue: 6 Pages: 704-710.e1
  • DOI: 10.1016/j.anai.2018.08.006
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Clinical significance of myeloperoxidase-anti-neutrophil cytoplasmic antibody in idiopathic interstitial pneumonias (2018)
  • Author(s): Hozumi Hironao、Oyama Yoshiyuki、Yasui Hideki、Suzuki Yuzo、Kono Masato、Karayama Masato、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: PLOS ONE Volume: 13 Issue: 6 Pages: e0199659-e0199659
  • DOI: 10.1371/journal.pone.0199659
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Switch maintenance therapy with docetaxel and bevacizumab after induction therapy with cisplatin, pemetrexed, and bevacizumab in advanced non-squamous non-small cell lung cancer: a phase II study (2018)
  • Author(s): Nishimoto Koji、Karayama Masato、Inui Naoki、Yasui Hideki、Hozumi Hironao、Suzuki Yuzo、Furuhashi Kazuki、Fujisawa Tomoyuki、Enomoto Noriyuki、Nakamura Yutaro、Inami Nao、Matsuura Shun、Kaida Yusuke、Matsui Takashi、Asada Kazuhiro、Matsuda Hiroyuki、Fujii Masato、Toyoshima Mikio、Imokawa Shiro、Suda Takafumi
  • Journal Title: Medical Oncology Volume: 35 Issue: 7 Pages: 108-108
  • DOI: 10.1007/s12032-018-1172-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognostic evaluation of serum ferritin in acute exacerbation of idiopathic pulmonary fibrosis (2018)
  • Author(s): Enomoto Noriyuki、Oyama Yoshiyuki、Enomoto Yasunori、Mikamo Masashi、Karayama Masato、Hozumi Hironao、Suzuki Yuzo、Kono Masato、Furuhashi Kazuki、Fujisawa Tomoyuki、Inui Naoki、Nakamura Yutaro、Suda Takafumi
  • Journal Title: The Clinical Respiratory Journal Volume: 12 Issue: 8 Pages: 2378-2389
  • DOI: 10.1111/crj.12918
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Utility of serum Aspergillus-galactomannan antigen to evaluate the risk of severe acute exacerbation in chronic obstructive pulmonary disease (2018)
  • Author(s): Yoshimura Katsuhiro、Suzuki Yuzo、Inoue Yusuke、Nishimoto Koji、Mori Kazutaka、Karayama Masato、Hozumi Hironao、Furuhashi Kazuki、Enomoto Noriyuki、Fujisawa Tomoyuki、Nakamura Yutaro、Inui Naoki、Yokomura Koushi、Imokawa Shiro、Suda Takafumi
  • Journal Title: PLOS ONE Volume: 13 Issue: 6 Pages: e0198479-e0198479
  • DOI: 10.1371/journal.pone.0198479
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinctive characteristics and prognostic significance of interstitial pneumonia with autoimmune features in patients with chronic fibrosing interstitial pneumonia. (2018)
  • Author(s): Yoshimura K, Kono M, Enomoto Y, Nishimoto K, Oyama Y, Yasui H, Hozumi H, Karayama M, Suzuki Y, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Inui N, Sumikawa H, Johkoh T, Colby TV, Sugimura H, Suda T.
  • Journal Title: Respiratory Medicine Volume: 137 Pages: 167-175
  • DOI: 10.1016/j.rmed.2018.02.024
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neutrophil gelatinase-associated lipocalin in patients with sarcoidosis. (2018)
  • Author(s): Kato S, Inui N, Hozumi H, Inoue Y, Yasui H, Karayama M, Kono M, Suzuki Y, Furuhashi K, Enomoto N, Fujisawa T, Nakamura Y, Watanabe H, Suda T.
  • Journal Title: Respiratory Medicine Volume: 印刷中 Pages: S20-S23
  • DOI: 10.1016/j.rmed.2018.01.004
  • Peer Reviewed / Int'l Joint Research
• [Presentation] 14-3-3γ Protein: A Novel Serum Biomarker for Predicting Prognosis in Idiopathic Pulmonary Fibrosis. (2020)
  • Author(s): Hozumi H, Isayama T, Okada J, Sugiura K, Yasui H, Suzuki Y, Kono M, Karayama M, Furuhashi K, Enomoto N, Fujisawa T, Inui N, Nakamura Y, Hayakawa H, Suda T
  • Organizer: American Thoracic Society 2020 International Conference
  • Int'l Joint Research
• [Presentation] 特発性肺線維症における14-3-3γ蛋白の臨床的有用性 (2020)
  • Author(s): 穗積宏尚, 安井秀樹, 鈴木勇三, 河野雅人, 柄山正人, 古橋一樹, 榎本紀之, 藤澤朋幸, 乾直輝, 中村祐太郎, 須田隆文
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] Clinical Utility of Serum S100 Calcium Binding Protein A4 in Idiopathic Pulmonary Fibrosis (2019)
  • Author(s): N. Akiyama, H. Hozumi, H. Yasui, M. Kono, Y. Suzuki, M. Karayama, K. Furuhashi, N. Enomoto, T. Fujisawa, N. Inui, Y. Nakamura, T. Suda
  • Organizer: ATS Conference 2019 - American Thoracic Society
  • Int'l Joint Research
• [Patent(Industrial Property Rights)] 特発性肺線維症の予後予測方法 (2019)
  • Inventor(s): 穗積宏尚
  • Industrial Property Rights Holder: 浜松医科大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2019-111310
  • Filing Date: 2019