Elucidation of the pathophysiology of chronic obstructive pulmonary disease and control of inflammation and emphysema focusing on neuropeptide Y

• Project/Area Number: 18K15950
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Okayama University
• Principal Investigator: Taniguchi Akihiko 岡山大学, 医歯薬学総合研究科, 助教 (90751123)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: ニューロペプチドY / 慢性閉塞性肺疾患 / 肺気腫 / NPY / COPD / IL-17 / 3型自然リンパ球 / ILC3 / 気道炎症

Outline of Final Research Achievements

To clarify how neuropeptide Y is involved in airway inflammation and development of emphysema in chronic obstructive pulmonary disease (COPD), we utilized mouse elastase-induced emphysema model and evaluated the airway inflammation, respiratory function, and lung histology.
These data suggest the protective effects of NPY against elastase-induced airway inflammation and pulmonary emphysema in this model.

Academic Significance and Societal Importance of the Research Achievements

慢性閉塞性肺疾患（COPD）におけるニューロペプチドYの役割を調べた研究報告は未だなく、世界初の研究となる。
COPDのさらなる病態解明や新たな治療開発につながる可能性がある。

Research Products

• [Presentation] Protective effect of neuropeptide Y against elastase-induced emphysema (2019)
  • Author(s): 谷口暁彦，小田尚廣，森近大介，妹尾賢，藤井詩子，板野純子，金廣有彦，木浦勝行，前田嘉信，宮原信明
  • Organizer: 米国胸部学会（ATS）
  • Int'l Joint Research