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Development of treatment strategy of pulmonary alveolar microlithiasis

Research Project

Project/Area Number 18K15956
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionSapporo Medical University

Principal Investigator

Saito Atsushi  札幌医科大学, 医学部, 助教 (00768939)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肺胞微石症 / 動物モデル / ナトリウムリン酸共輸送体 / 治療法開発 / 肺胞マクロファージ / 肺サーファクタント / 疾患モデル動物 / ナトリウムリン共輸送体 / マウスモデル
Outline of Final Research Achievements

Alveolar pulmonary microlithiasis (PAM) is an autosomal recessive rare lung disease that causes microliths in the alveolar space due to the deficiency of sodium phosphate cotransporter 2b(Npt2b). We have already reported that a low-phosphate diet prevented and/or diminished microlith formation in PAM mouse model. However, although phosphate dietary restriction is easily accomplished in mice, phosphate is ubiquitous in the human diet and attempts to limit intake are often unsuccessful. Phosphate binders are widely used in hyperphosphatemic patients with CKD. We found that oral administration of phosphate binders to PAM mice attenuated the microlith burden in the lung without appreciable adverse effects. Also, lipidomics analysis revealed a marked increase in eicosanoids such as arachidonic acid and COX-2. These results help to elucidate the molecular mechanism and may be used as a marker that reflects the pathological condition of PAM.

Academic Significance and Societal Importance of the Research Achievements

肺胞微石症は非常にまれな遺伝性の呼吸器疾患です。これまでに治療法がなく健康な人と比較して短命であることもわかっています。私達はこれまでにマウスモデルを作成して治療法についての検討をおこなってきましたが、今回の研究でさらに一歩前進してすでに他の疾患で臨床応用されている薬剤であるリン酸吸着剤を用いて検討しマウスにおける病態を改善することができました。さらに先進的な解析技術を用いることで患者さんの病勢を把握するマーカーとなる物質もいくつか発見することができました。今後はさらにこれらの結果を臨床応用できるように研究を推進したいと思っています。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (11 results)

All 2019 2018

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Autoimmune Pulmonary Alveolar Proteinosis Diagnosed after Exposure to a Fire Extinguisher Containing Silica Powder2019

    • Author(s)
      Yorozuya Takafumi、Ikeda Kimiyuki、Chiba Hirofumi、Saito Atsushi、Kuronuma Koji、Nishikiori Hirotaka、Miyajima Satsuki、Takahashi Mamoru、Yoshikawa Takumi、Takahashi Youhei、Taya Tetsuya、Mori Yuki、Umeda Yasuaki、Otsuka Mitsuo、Moriyama Hiroshi、Takahashi Hiroki
    • Journal Title

      Internal Medicine

      Volume: 58 Issue: 14 Pages: 2067-2072

    • DOI

      10.2169/internalmedicine.1557-18

    • NAID

      130007679540

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2019-07-15
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Insufficient serum L-ficolin is associated with disease presence and extent of pulmonary Mycobacterium avium complex disease2019

    • Author(s)
      Kobayashi Tomofumi、Kuronuma Koji、Saito Atsushi、Ikeda Kimiyuki、Ariki Shigeru、Saitou Atsushi、Otsuka Mitsuo、Chiba Hirofumi、Takahashi Satoshi、Takahashi Motoko、Takahashi Hiroki
    • Journal Title

      Respiratory Research

      Volume: 20 Issue: 1 Pages: 224-224

    • DOI

      10.1186/s12931-019-1185-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of therapeutic effects of inhaled corticosteroids on three subtypes of cough variant asthma as classified by the impulse oscillometry system2019

    • Author(s)
      Sugawara Hiroyuki、Saito Atsushi (Corresponding Author)、Yokoyama Saori、Tsunematsu Kazunori、Takahashi Hiroki
    • Journal Title

      Respiratory Research

      Volume: 20 Issue: 1 Pages: 41-50

    • DOI

      10.1186/s12931-019-1005-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of distal airway stem-like cells expressing N-terminally truncated p63 and thyroid transcription factor-1 in the human lung.2018

    • Author(s)
      Tanaka Y, Yamaguchi M, Hirai S, Sumi T, Tada M, Saito A, Chiba H, Kojima T, Watanabe A, Takahashi H, Sakuma Y.
    • Journal Title

      Exp Cell Res.

      Volume: 372(2) Issue: 2 Pages: 141-149

    • DOI

      10.1016/j.yexcr.2018.09.020

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Response to pneumococcal vaccine in interstitial lung disease patients: Influence of systemic immunosuppressive treatment2018

    • Author(s)
      Kuronuma Koji、Honda Hiroyuki、Mikami Tessei、Saito Atsushi、Ikeda Kimiyuki、Otsuka Mitsuo、Chiba Hirofumi、Yamada Gen、Sato Toyotaka、Yokota Shin-ichi、Takahashi Hiroki
    • Journal Title

      Vaccine

      Volume: 36 Issue: 33 Pages: 4968-4972

    • DOI

      10.1016/j.vaccine.2018.06.062

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 臨床応用を目指した肺胞微石症の基礎および治療法の検討2019

    • Author(s)
      齋藤充史、高宮里奈、藤谷直樹、有木茂、黒沼幸治、千葉弘文、高橋素子、高橋弘毅
    • Organizer
      日本肺サーファクタント界面医学会 第55回学術研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 臨床応用を目指した肺胞微石症の基礎および治療法の検討2019

    • Author(s)
      齋藤充史、齋藤淳、藤谷直樹、有木茂、高橋素子、高橋弘毅
    • Organizer
      日本呼吸器学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pulmonary Alveolar Microlithiasis ~ Epidemiology in Japan and Developing treatment strategies in a novel mouse model ~2019

    • Author(s)
      A. Saito, R. Takamiya, N. Fujitani, S. Ariki, K. Kuronuma, H. Chiba, M. Takahashi, H. Takahashi
    • Organizer
      The European Respiratory Society International Congress
    • Related Report
      2019 Annual Research Report
  • [Presentation] 臨床応用を目指した肺胞微石症の基礎および治療法の検討2019

    • Author(s)
      齋藤充史、齋藤淳、藤谷直樹、有木茂、高橋素子、高橋弘毅
    • Organizer
      日本呼吸器学会年次学術集会 2019年4月
    • Related Report
      2018 Research-status Report
  • [Presentation] Pulmonary Alveolar Microlithiasis ~ Epidemiology in Japan and Developing treatment strategies in a novel mouse model2018

    • Author(s)
      Atsushi Saito, Yusuke Tanaka, Shigeru Ariki, Motoko Takahashi, Hiroki Takahashi
    • Organizer
      Rare lung Disease Consortium 2018, Cincinnati, OH, USA
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 臨床応用に向けた肺胞微石症の病態解析2018

    • Author(s)
      齋藤充史
    • Organizer
      日本呼吸器学会年次学術集会 2018年4月
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2021-02-19  

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