clinical exmination on eosinophilic inflammation caused by NSAIDs and PGE2 / EP3 gene polymorphism.
| Project/Area Number |
18K15957
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Kaneko Yoshiko 京都府立医科大学, 医学(系)研究科(研究院), 助教 (30768825)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Stevens-Johnson症候群 / 閉塞性細気管支炎 / 好酸球性炎症 / PTGER遺伝子多型 / Steven-Jhonson症候群 / 早期増悪型 / 慢性期進行型 / PGE2/EP3受容体 / アスピリン喘息 / 遺伝子多型 |
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| Outline of Final Research Achievements |
We confirmed that bronchiolitis obliterans, which is one of the respiratory complications secondary to SJS / TEN, has various clinical features such as acute onset, subacute progression, and chronic progression over 10 years. We showed that a quantitative analysis of a chest CT scan matched the increase in total lung volume with airway remodeling and hyperinflation changes. In the PTGER polymorphism rs 7543182, the aspirin asthma population was associated with T allele, which was positively correlated with EP3 protein expression. The result was the opposite of SJS / TEN ocular sequelae.
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| Academic Significance and Societal Importance of the Research Achievements |
アスピリン喘息ではEP3蛋白発現において正の相関が示唆され、EP3発現の豊富な血小板を介した炎症経路や気道粘膜におけるPGE2-EP3を介した気道炎症制御機構など本疾患の病態の理解を支持する結果を認めた。本研究により、SJS/TEN呼吸器合併症、特に閉塞性細気管支炎の多彩な臨床像が明らかになり、胸部CT定量的解析により気道病変の詳細な画像的検討を行った。日本アレルギー学会・日本呼吸器学会等の基盤学会における本研究の学会発表及び誌上報告により、診療及び研究両面での診療科横断的な協力基盤（皮膚科・眼科・内科）が構築された。
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to atopy2020
Author(s)
Haruna Kitazawa, Hironori Masukoa Jun Kanazawaa,Rie Shigemasa, Kentaro Hyodoa, Hideyasu Yamada, Yohei Yatagai, Yoshiko Kaneko, Hiroaki Iijima, Takashi Naito, Takefumi Saito, Emiko Noguchi, Satoshi Konno, Tomomitsu Hirota, Mayumi Tamari, Tohru Sakamoto, Nobuyuki Hizawa
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Journal Title
Allergology International
Volume: -
Related Report
Peer Reviewed / Open Access
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[Journal Article] A cis-eQTL allele regulating reduced expression of CHI3L1 is associated with late-onset adult asthma in Japanese cohorts.2019
Author(s)
Kanazawa J, Kitazawa H, Masuko H, Yatagai Y, Sakamoto T, Kaneko Y, Iijima H, Naito T, Saito T, Noguchi E, Konno S, Nishimura M, Hirota T, Tamari M, Hizawa N
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Journal Title
BMC Medical Genetics
Volume: 20
Pages: 58-58
DOI
NAID
Related Report
Peer Reviewed / Open Access
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