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Programmed cell death in ANCA-associated vasculitis

Research Project

Project/Area Number 18K15968
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53040:Nephrology-related
Research InstitutionHokkaido University

Principal Investigator

Nakazawa Daigo  北海道大学, 大学病院, 助教 (60724135)

Project Period (FY) 2018-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords血管炎 / 腎炎 / ANCA / NETs / リコモジュリン / プログラム細胞死 / 好中球 / プログラムネクローシス / 自己免疫疾患 / 好中球細胞死
Outline of Final Research Achievements

We focused on the effect of recomodulin in ANCA associated vasculitis (AAV). Neutrophil extracellular traps (NETs) are deeply involved in the pathogenesis of AAV and lead to the vascular injury. We showed that in vitro experiment recomodulin inhibit NETs formation and protect endothelium during vascular injury. Furthermore, rTM ameliorated AAV manifestation in AAV model animal. The treatment of rTM would be novel therapeutic agent in AAV patients.

Academic Significance and Societal Importance of the Research Achievements

ANCA関連腎炎は壊死性半月体形成性糸球体腎炎や肺出血を呈する重篤な疾患であり、近年強力な免疫抑制治療により寛解導入率は向上してきたが、治療関連感染症死が60%と非常に多いため、依然として予後は不良であり、特異的な治療の開発が必要である。本治療は、過剰な免疫抑制を引き起こさずに病態を改善する可能性があり、またすでに敗血症/DIC病態に対して臨床使用され安全性も確認されており、新規治療薬として臨床応用できる可能性がある。

Report

(3 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2020

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Recombinant thrombomodulin ameliorates autoimmune vasculitis via immune response regulation and tissue injury protection.2020

    • Author(s)
      Kanako Watanabe-Kusunoki
    • Journal Title

      J Autoimmun.

      Volume: 108 Pages: 102390-102390

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2018-04-23   Modified: 2021-02-19  

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