| Project/Area Number |
18K15978
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Okayama University |
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Principal Investigator |
Tsuji Kenji 岡山大学, 医歯薬学総合研究科, 助教 (10816995)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 糸球体上皮細胞 / Semaphorin3A / 蛋白尿 / アポトーシス / Semaphorin / Podocyte |
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| Outline of Final Research Achievements |
In this study, we identified that the upregulation of Semaphorin3A in glomerular epithelial cells is involved in the development of glomerular epithelial cell damage. In a mouse model of Adriamycin-induced glomerular epithelial cell injury, we identified that the increased expression of Semaphorin3A in glomerular epithelial cells induces apoptosis, and that the disorder is alleviated by a Semaphorin3A inhibitor.
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| Academic Significance and Societal Importance of the Research Achievements |
糸球体上皮細胞障害の病態機序をSemaphorin3Aに着目して明らかにし、さらにSemaphorin3A阻害剤を用いた糸球体上皮細胞保護効果を証明した。これらの研究成果は、国内外において初めて報告された独創的な研究成果であり、Semaphorin3A制御による糸球体上皮細胞障害に対する新規治療法につながる治験である。
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