| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In our university, we assessed 96 cases of kidney biopsy findings including arterial hyalinosis, arteriosclerosis, interstitial fibrosis and tubular atrophy (IFTA), global sclerosis rate (GS), and CKD-MBD biomarkers, cardiac biomarkers, and insulin resistance biomarkers. In multivariate analysis, IFTA was significantly associated with 1,25 vitamin D and BNP, and GS was significantly associated with FGF23, BNP and FGF21. There was no association with biomarkers and arterial hyalinosis. Next, we examined 54 cases following up for 2 years. There was no significant association between the histological findings including arterial hyalinosis, arteriosclerosis, and IFTA and the renal endpoints (increased serum creatinine 1.5-fold, induction of dialysis, renal transplantation).
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