| Project/Area Number |
18K16014
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 慢性腎臓病 / CADM1 / 尿細管間質炎 / NK細胞 / T細胞 / バイオマーカー / 細胞間接着分子 / CRTAM / 血管内皮細胞障害 / 細胞障害性因子 / 腎移植 / 接着分子 |
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| Outline of Final Research Achievements |
Elevation of urinary CADM1 concentration was seen in the patient (n=44) based on various glomerulonephritis and nephropathy, but not in the rest of patients (n=83). Although urinary CADM1 concentration didn`t have no correlations with pathological tubulointerstitial injuries (epithelial degeneration, interstitial inflammation, and fibrosis), there was a weak inverse correlation between pathological injury scores and estimated glomerular filtration ratio. Notably, this correlation gradually increased in patients with high level CADM1 concentrations, and reached a maximum at a cutoff of 1,569 pg/ml. These results suggest that urinary CADM1 may be a useful marker indicating tubulointerstitial damage.
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| Academic Significance and Societal Importance of the Research Achievements |
尿中CADM1 shedding産物は尿細管でのCADM1 shedding状態を反映すると推定され、尿細管変性を直接的に推測しうる新マーカーとして意義深いと考える。今後、CADM1と相互作用を示すと推定されるCRTAM陽性細胞障害性Tリンパ球やCRTAM陽性NK（Natural killer）細胞の尿細管間質病変形成への関与を証明できれば、CADM1が慢性腎臓病の病態理解に新機軸をもたらすと期待される。
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