Role of cell adhesion molecule 1 (CADM1) in chronic kidney disease
| Project/Area Number |
18K16014
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 慢性腎臓病 / CADM1 / 尿細管間質炎 / NK細胞 / T細胞 / バイオマーカー / 細胞間接着分子 / CRTAM / 血管内皮細胞障害 / 細胞障害性因子 / 腎移植 / 接着分子 |
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| Outline of Final Research Achievements |
Elevation of urinary CADM1 concentration was seen in the patient (n=44) based on various glomerulonephritis and nephropathy, but not in the rest of patients (n=83). Although urinary CADM1 concentration didn`t have no correlations with pathological tubulointerstitial injuries (epithelial degeneration, interstitial inflammation, and fibrosis), there was a weak inverse correlation between pathological injury scores and estimated glomerular filtration ratio. Notably, this correlation gradually increased in patients with high level CADM1 concentrations, and reached a maximum at a cutoff of 1,569 pg/ml. These results suggest that urinary CADM1 may be a useful marker indicating tubulointerstitial damage.
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| Academic Significance and Societal Importance of the Research Achievements |
尿中CADM1 shedding産物は尿細管でのCADM1 shedding状態を反映すると推定され、尿細管変性を直接的に推測しうる新マーカーとして意義深いと考える。今後、CADM1と相互作用を示すと推定されるCRTAM陽性細胞障害性Tリンパ球やCRTAM陽性NK（Natural killer）細胞の尿細管間質病変形成への関与を証明できれば、CADM1が慢性腎臓病の病態理解に新機軸をもたらすと期待される。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Urinary cell adhesion molecule 1 is a novel biomarker that links tubulointerstitial damage to glomerular filtration rates in chronic kidney disease.2019
Author(s)
Hagiyama M, Nakatani Y, Takashima Y, Kato T, Inoue T, Kimura R, Otani T, Sato Y, Mori H, Arima S, Ito A
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Journal Title
Frontiers in Cell and Development Biology
Volume: 7
Pages: 111-111
DOI
Related Report
Peer Reviewed / Open Access
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