Research for biomarkers for early diagnosis of severe drug eruption by proteome analysis
| Project/Area Number |
18K16020
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Niigata University |
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Principal Investigator |
Hama Natsumi 新潟大学, 医歯学総合病院, 講師 (50529625)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 重症薬疹 / バイオマーカー / スティーブンス・ジョンソン症候群 / 中毒性表皮壊死症 / Stevens-Johnson症候群 / プロテオミクス / スティーブンスジョンソン症候群 / プロテオーム解析 |
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| Outline of Final Research Achievements |
Severe drug eruptions, mainly Stevens-Johnson syndrome and toxic epidermal necrolysis, are rare but can cause sequelae and be lethal. Until now, research on biomarkers for early diagnosis and prediction of severity has not been sufficient. In this study, galectin-7, a new biomarker candidate, was identified by a comprehensive search using proteome analysis. Galectin-7 has high disease specificity and is considered to be effective for early diagnosis.
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| Academic Significance and Societal Importance of the Research Achievements |
本邦の最近の統計によると中毒性表皮壊死症の致死率は未だ約30％と高い。Stevens-Johnson症候群および中毒性表皮壊死症では、いかに確実に早期診断を行い、早期治療を開始するかということが最重要であるものの、発症早期に正確な診断をすることは非常に困難である。そこで今回同定したgalectin-7のようなバイオマーカーが診断の補助として有用である可能性があり、早期診断に寄与できれば救命率が上昇する可能性がある。今後は臨床応用を目指していきたい。
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Galectin-7 as a potential biomarker of Stevens-Johnson syndrome/ toxic epidermal necrolysis: Identification by targeted proteomics using causative drug-exposed peripheral blood cells2019
Author(s)
Natsumi Hama, Keiko Nishimura, Akito Hasegawa, Akihiko Yuki, Hideaki Kume, Jun Adachi, Manao Kinoshita, Youichi Ogawa, Saeko Nakajima, Takashi Nomura, Hideaki Watanabe, Yoshiko Mizukawa, Takeshi Tomonaga, Hiroshi Shimizu, Riichiro Abe
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Journal Title
J Allergy Clin Immunol Pract
Volume: 印刷中
Issue: 8
Pages: 2894-2897
DOI
Related Report
Peer Reviewed
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