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Analysis of the mechanism of exacerbation of psoriasis by the epidermal basal cell proliferation-enhancing effect of diet-derived oxidized sterols

Research Project

Project/Area Number 18K16026
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53050:Dermatology-related
Research InstitutionOsaka University

Principal Investigator

Saga Ayami  大阪大学, 医学系研究科, 特任研究員(常勤) (10535925)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords7-ketocholesterol / 乾癬 / IL-23 / IL-17 / 酸化コレステロール / 酸化ステロール / コレステロール / T細胞
Outline of Final Research Achievements

We analyzed whether 7-ketocholesterol (7-KC), a dietary exogenous oxidized sterol, exacerbate psoriasis-like dermatitis in mice. After mice fed with high-fat, high-cholesterol bile acid ± 7-KC for 3 weeks, which induced psoriasis-like dermatitis by treated with imiquimod cream to the auricle and back skin for 4 days. At 7-KC (+), the auricular thickness increased and the epidermal layer of the back skin thickened. The amount of IL-23a and IL-17 mRNA increased in the 7-KC (+) in the back skin. These suggest that 7-KC contributed to the acceleration of psoriasis-like dermatitis.

Academic Significance and Societal Importance of the Research Achievements

乾癬、動脈硬化、非アルコール性脂肪肝炎 (NASH) は、疫学的に重複して発症すると示唆されているが、共通する特定の背景は報告されていない。食餌由来の外因性酸化ステロールである7-ketocholesterol (7-KC)は、様々な慢性炎症性疾患を惹起する可能性があることが報告されている。しかし、7-KCが乾癬を促進させるとの報告はなかった。今回の研究で、7-KCの摂取・蓄積により乾癬様皮膚炎の病態が悪化すること、並びにその分子メカニズムが明らかになれば、腸管での吸収に着目した新しい食事・薬物療法を提案できると考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (13 results)

All 2021 2020 2019

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (12 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Dietary oxysterol, 7-Ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese Mice2021

    • Author(s)
      J. Chang, M. oseki, A. Saga, K. Kanno, T. Higo, D. Okuzaki, T. Okada, H. Inui, K. Tanaka, M. Asaji, Y. Zhu, K. Yamada, M. Ono, T. Saibara, I Ichi, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 11 Pages: 614692-614692

    • DOI

      10.3389/fendo.2020.614692

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] High Fat Diet Containing 7-Ketocholesterol Induces Steatohepatitis and Cardiac Inflammation in STZ-Induced Diabetic Mice2021

    • Author(s)
      Masahiro Koseki、Juyang Chang、Kotaro Kanno、Ayami Saga、Hiroyasu Inui、Takeshi Okada、Shigeyoshi Saito、Tomoaki Higo、Seiko Ide、Katsunao Tanaka、Yinghong Zhu、Toru Ohhama、Makoto Nishida、Shizuya Yamashita、Yasushi Sakata
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食餌誘導性脂肪肝炎マウスモデルにおいて7-ketocholesterolは乾癬様皮膚炎を促進させる2020

    • Author(s)
      嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、鎌田佳宏、乾洋勉、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
    • Organizer
      第62回日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食事由来7-ketocholesterolは、Ldl受容体欠損マウスにおいて、脂肪肝炎とアテローム性動脈硬化症を憎悪させる2020

    • Author(s)
      冠野昂太郎、小関正博、嵯峨礼美、常久洋、岡田健志、乾洋勉、朝治真澄、朱穎竑、大濵透、鎌田佳宏、西田誠、山下静也、坂田泰史
    • Organizer
      第62回日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The dietary 7-ketocholesterol accelerated steatohepatitis in ob/ob mice.2020

    • Author(s)
      Chang J, Koseki M, Saga A, Kanno K, Okada T, Saito S, Kamada Y, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      第62回日本脂質生化学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる2020

    • Author(s)
      嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、鎌田佳宏、乾洋勉、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Dietary oxysterol, 7-ketocholesterol accelerated steatohepatitis and atherosclerosis in Ldlr deficient mice model2020

    • Author(s)
      冠野昂太郎、小関正博、嵯峨礼美、常久洋、岡田健志、乾洋勉、朝治真澄、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響2020

    • Author(s)
      小関正博、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、乾洋勉、鎌田佳宏、山下静也、坂田泰史
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] イミキモド誘導乾癬モデルマウスにおける食事誘導脂肪肝炎の影響2020

    • Author(s)
      嵯峨礼美、常久洋、小関正博
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The dietary 7-Ketocholesterol accelerated steatohepatitis in ob/ob mice by suppressing autophagy2020

    • Author(s)
      常久洋、小関正博、 嵯峨礼美
    • Organizer
      第56回日本肝臓学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prevalence of Coronary Artery Disease and Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients at Osaka University Hospital2020

    • Author(s)
      Koseki M, Kanno K, Saga A, Chang J, Inui H, Okada T, Ohama T, Nishida M, Kamada Y, Miyoshi E, Yamashita S, Sakata Y.
    • Organizer
      88th European Atherosclerosis Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A dietary oxysterol, 7-ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitis mice2020

    • Author(s)
      Saga A, Koseki M, Kanno K, Chang J, Asaji M, Okada T, Inui H, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
    • Organizer
      日本研究皮膚科学会 第45回年次学術大会・総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 乾癬様皮膚炎マウスモデルにおける外因性酸化ステロールの影響の検討2019

    • Author(s)
      嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、乾洋勉、朱頴広、大濵透、西田誠、山下静也、坂田泰史
    • Organizer
      第51回日本動脈硬化学会総会・学術集会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2023-01-30  

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