A novel approach of epithelial regeneration during wound healing based on the concept of EMT-MET
| Project/Area Number |
18K16032
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOIKE Yuta 長崎大学, 病院(医学系), 講師 (10530412)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚再生学 |
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| Outline of Final Research Achievements |
Our purpose of this study is to elucidate the molecular mechanism of wound healing from the viewpoint of "epithelial-mesenchymal transition (EMT)" and "mesenchymal-epithelial transition (MET)" and find a new therapeutic target for intractable skin ulcer. In a mouse skin wound model, administration of FGF2 promoted wound healing process and activated EMT in epidermal keratinocytes at wound edge, accompanied by general upregulation EMT-related molecules in the wound tissue. In addition, study with a human epidermal keratinocyte model revealed that FGF2 might induce EMT in cooperation with TGFβ1 to accelerate wound healing.
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| Academic Significance and Societal Importance of the Research Achievements |
創傷治癒過程で最も重要な因子は、表皮角化細胞の足場となる良質な肉芽の形成である。それゆえ臨床の場で皮膚潰瘍に対して使用されている外用薬は、肉芽の生育を主な目的としている。一方、肉芽形成良好であるが再上皮化しない難治性皮膚潰瘍も多数ある。本研究は創傷の再上皮化過程、特に表皮角化細胞のEMT-METを詳細に解析したものであり、今後の発展によっては再上皮化困難な皮膚潰瘍の治療ターゲットを見つけ出すことも可能であろう。
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Report
(3 results)
Research Products
(43 results)
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[Presentation] A case report: Pregnancy-related complications in a woman with Ehlers-Danlos syndrome with biallelic variant in AEBP-12019
Author(s)
Hiromi Sanai, Mami Oshita, Mana Kawasaki, Takahiro Sakai, Terumi Miwa, Keiko Otani, Hiromi Asada, Ichiro Miwa, Masakatsu Sase, Yasuhiko Nakamura, Yoshiko Nawata, Hiroki Hamano, Keiko Hasegawa, Masahiko Muto, Yuuta Koike, Hiroyuki Murota, Atsushi Utani
Organizer
2019 Scientifc Meeting on the Rarer Types of Ehlers-Danlos Syndromes
Related Report
Int'l Joint Research
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