| Project/Area Number |
18K16032
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOIKE Yuta 長崎大学, 病院(医学系), 講師 (10530412)
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| Project Period (FY) |
2018-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚再生学 |
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| Outline of Final Research Achievements |
Our purpose of this study is to elucidate the molecular mechanism of wound healing from the viewpoint of "epithelial-mesenchymal transition (EMT)" and "mesenchymal-epithelial transition (MET)" and find a new therapeutic target for intractable skin ulcer. In a mouse skin wound model, administration of FGF2 promoted wound healing process and activated EMT in epidermal keratinocytes at wound edge, accompanied by general upregulation EMT-related molecules in the wound tissue. In addition, study with a human epidermal keratinocyte model revealed that FGF2 might induce EMT in cooperation with TGFβ1 to accelerate wound healing.
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| Academic Significance and Societal Importance of the Research Achievements |
創傷治癒過程で最も重要な因子は、表皮角化細胞の足場となる良質な肉芽の形成である。それゆえ臨床の場で皮膚潰瘍に対して使用されている外用薬は、肉芽の生育を主な目的としている。一方、肉芽形成良好であるが再上皮化しない難治性皮膚潰瘍も多数ある。本研究は創傷の再上皮化過程、特に表皮角化細胞のEMT-METを詳細に解析したものであり、今後の発展によっては再上皮化困難な皮膚潰瘍の治療ターゲットを見つけ出すことも可能であろう。
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