Role of EpCAM function in skin and gut immunity
| Project/Area Number |
18K16038
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | EpCAM / 細胞接着分子 / 皮膚免疫 / 腸管免疫 / 乾癬 / イミキモド / イミキモド皮膚炎 |
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| Outline of Final Research Achievements |
Epithelial cell adhesion molecule (EpCAM) is essential for maintaining of intestinal stem cells. The function of EpCAM for skin immunity is now investigated by using imiquimod-induced psoriasis like dermatitis model.
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| Academic Significance and Societal Importance of the Research Achievements |
EpCAMの欠損は重度の腸管障害を引き起こす。EpCAMの機能を解析することで、治療法の開発に役立てることができる。また、EpCAMは皮膚免疫にも関与していると考えられ、皮膚免疫におけるEpCAMの機能を解明すれば、皮膚炎などの治療法の開発に貢献できる。
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Report
(6 results)
Research Products
(3 results)
