Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Outline of Final Research Achievements |
In this study, we analyzed the effect of plasminogen (Plg) on the development of atherosclerosis in mice double-deficient (Ldlr-/-/Apobec1-/-) in the LDL receptor and RNA-editing enzyme APOBEC1, a mouse model of human type IIa familial hyperlipidemia, the most common form of hyperlipidemia in humans. Plg did not affect the expression of scavenger receptors involved in LDL uptake by Mφ, suggesting a novel pathogenetic mechanism that controls Mφ atherosclerosis progression by directly regulating LDL size.
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