| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the role of SATB1 on mature B cells. SATB1 controls various genes' expression by remodeling chromatin architecture. By analyzing SATB1/tomato reporter mice, we found SATB1 high Naive B cells are more likely to activate against antigen stimulation than SATB1 low naive B ccells. We made B cell specific SATB1 knock out mice (cKO mice) and analyzed them. We found that naive B cells of cKO mice reduced expression of antigen presenting molecule such as MHC II and CD86 against B cell receptor stimulation. These results suggested that SATB1 helps naive B cells to be activated against antigen stimulation.
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