Association of breast milk miRNA with the pathogenesis of atopic dermatitis
Project/Area Number |
18K16138
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Research Category |
Grant-in-Aid for Early-Career Scientists
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Allocation Type | Multi-year Fund |
Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
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Research Institution | Chiba University |
Principal Investigator |
Nakano Taiji 千葉大学, 医学部附属病院, 助教 (90708306)
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Project Period (FY) |
2018-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 母乳 / microRNA / アトピー性皮膚炎 / 食物アレルギー / アレルギー |
Outline of Final Research Achievements |
In a high-risk birth cohort study, breastfeeding (OR: 2.64, 95% CI: 1.45-4.81) was found to be a risk factor for egg white sensitization at one year of age. These results suggest that immune substances and microRNAs in breast milk may be involved in egg white sensitization. Therefore, we analyzed miRNA expression in breast milk samples from five atopic dermatitis (AD) subjects and five non-AD subjects, and found that hsa-miR-342-5p was significantly lower in the AD group than in the non-AD group. In silico analysis showed that hsa-miR-342-5p was involved in VEGF, TGFb signaling and may be involved in the development of allergic diseases.
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Academic Significance and Societal Importance of the Research Achievements |
アトピー性皮膚炎含むアレルギー疾患は有病率も高く、QOLを著しく低下させるためその予防や病態解明は社会的意義が高い。また、離乳食が始まる前の新生児期から乳児期は母乳もしくは人工乳が唯一の栄養であり児に与える影響は大きい。母乳栄養が卵白感作のリスク因子となることが我々の独立した2つの出生コホート研究から分かっており、アレルギー疾患発症にも母乳成分が関与している可能性が示唆された。今回は母乳中のmiRNAに着目して研究を行い、母乳中のある特定のmiRNAがアトピー性皮膚炎発症した児において低値であることが判明したことで今後さらに母乳中成分の関わりが着目される。
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Report
(6 results)
Research Products
(18 results)
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[Journal Article] Long-chain saturated fatty acids in breast milk are associated with the pathogenesis of atopic dermatitis via induction of inflammatory ILC3s.2021
Author(s)
Kong WS, Tsuyama N, Inoue H, Guo Y, Mokuda S, Nobukiyo A, Nakatani N, Yamaide F, Nakano T, Kohno Y, Ikeda K, Nakanishi Y, Ohno H, Arita M, Shimojo N, Kanno M.
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Journal Title
Scientific Reports
Volume: 11
Issue: 1
Pages: 13109-13109
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Precision medicine reaching out to the patients in allergology - a German-Japanese workshop report2021
Author(s)
Pfaar O, Blumchen K, Boateng E, Hamelmann E, Iinuma T, Jakob T, Krauss-Etschmann S, Nagase H, Nakajima S, Nakano T, Renz H, Sato S, Taube C, Wagenmann M, Werfel T, Worm M, Izuhara K
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Journal Title
Allergologie select
Volume: 5
Issue: 01
Pages: 162-179
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Breastfeeding Promotes Egg White Sensitization in Early Infancy2020
Author(s)
Nakano T, Ochiai S, Suzuki S, Yamaide F, Morita Y, Inoue Y, Arima T, Kojima H, Suzuki H, Nagai K, Morishita N, Hata A, Shozu M, Suzuki Y, Taniguchi M, Takemori T, Kohno Y, Shimojo N.
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Journal Title
Pediatr Allergy Immunol
Volume: 31(3)
Issue: 3
Pages: 315-318
DOI
Related Report
Peer Reviewed
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[Journal Article] Staphylococcus Agr virulence is critical for epidermal colonization and associates with atopic dermatitis development2020
Author(s)
Nakamura Y, Takahashi H, Takaya A, Inoue Y, Katayama Y, Kusuya Y, Shoji T, Takada S, Nakagawa S, Oguma R, Saito N, Ozawa N, Nakano T, Yamaide F, Dissanayake E, Suzuki S, Villaruz A, Varadarajan S, Matsumoto M, Kobayashi T, Kono M, Sato Y, Akiyama M, Otto M, Matsue H, Nunez G, Shimojo N.
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Journal Title
Sci Transl Med.
Volume: 8
Issue: 551
Pages: 4068-4068
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Skin Care and Synbiotics for Prevention of Atopic Dermatitis or Food Allergy in Newborn Infants: A 2 × 2 Factorial, Randomized, Non-Treatment Controlled Trial2019
Author(s)
Dissanayake E, Tani Y, Nagai K, Sahara M, Mitsuishi C, Togawa Y, Suzuki Y, Nakano T, Yamaide F, Ohno H, Shimojo N.
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Journal Title
Int Arch Allergy Immunol
Volume: 180(3)
Issue: 3
Pages: 202-211
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of the Maternal Microbiome in Japanese Pregnant Women With the Cumulative Prevalence of Dermatitis in Early Infancy: A Pilot Study From the Chiba Study of Mother and Child Health Birth Cohort2019
Author(s)
Tanabe H, Sakurai K, Kato T, Kawasaki Y, Nakano T, Yamaide F, Taguchi-Atarashi N, Watanabe M, Ochiai S, Ohno H, Fukuoka H, Shimojo N, Mori C.
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Journal Title
World Allergy Organ J
Volume: 1;12(10)
Issue: 10
Pages: 100065-100065
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis.2019
Author(s)
Dissanayake E, Inoue Y, Ochiai S, Eguchi A, Nakano T, Yamaide F, Hasegawa S, Kojima H, Suzuki H, Mori C, Kohno Y, Taniguchi M, Shimojo N
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Journal Title
J Allergy Clin Immunol.
Volume: Jan;143(1)
Issue: 1
Pages: 447-450
DOI
Related Report
Peer Reviewed
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