| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Although TRIM proteins and related molecules are expected to be involved in a complex manner in systemic lupus erythematosus (SLE), the direct relationship between SLE pathogenesis and TRIM proteins remains unclear. In this study, we generated Trim39 knockout mice and analyzed the immunological role of TRIM39. We found that Trim39-/- mice had significantly larger thymus and spleen weights and a significantly higher number of spleen cells compared to wild-type mice. The expression of STAT1 was significantly upregulated in the B cells of Trim39-/- mice compared to wild-type mice, and the expression of IL-1 was significantly upregulated in the blood of Trim39-/- mice compared to wild-type mice. Trim39-/- mice had significantly higher levels of IL-27 and significantly lower levels of IgG1 and IgA in blood. The amount of IgA in feces was also significantly lower and DSS-induced enteritis was more severe in Trim39-/- mice.
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