| Project/Area Number |
18K16186
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54030:Infectious disease medicine-related
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 結核 / 検査 / 性周期 / インターフェロンγ遊離試験 / 性ホルモン |
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| Outline of Final Research Achievements |
We performed clinical studies to investigate the hypothesis that sex cycles affects the test results of Interferon gamma releasing assay (IGRA) among premenopausal females. According to our study results, there were no apparent relationship between sex cycles and IGRA test results, suggesting IGRA tests can be performed regardless of sex cycles among premenopausal females.
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| Academic Significance and Societal Importance of the Research Achievements |
インターフェロンγ遊離試験(IGRA)は、医療従事者の結核曝露時健診などで用いられることが多いが、医療従事者には閉経前女性の比率が多く含まれるため、検査結果が性周期の影響を受けると適切に結核曝露時のリスク評価ができない可能性が懸念されたが、本研究の成果によりその懸念を払拭することができた。これは、結核曝露に対する感染管理を行なっていく上で有用な知識となりうる。
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