Effect of incretin GIP on bone metabolism in vivo
| Project/Area Number |
18K16197
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | インクレチン / 骨 / GIP |
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| Outline of Final Research Achievements |
We analyzed the phenotype of osteoblast-specific GIP receptor-deficient mice. In osteoblast-specific GIP receptor-deficient mice, there was no significant difference in the expression of GIP receptors in the following organs: bone, islets, brain, intestine, visceral fat, subcutaneous fat, and brown fat. Whole body bone length was measured using soft X-rays, but no significant difference was observed. No significant differences were found in glucose tolerance, GIP, or insulin secretion capacity. μCT analysis was performed to analyze bone density, but no significant differences were found. We confirmed GIP receptor expression in osteoblast culture, osteoclast culture, and cell line, but GIP receptor expression could not be confirmed using primary culture.
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| Academic Significance and Societal Importance of the Research Achievements |
骨組織におけるGIP（Gastric inhibitory polypeptide）の生体内での役割を明らかにするために、骨芽細胞特異的GIP受容体欠損マウスを作製した。骨芽細胞のGIP作用についてin vivoで検討した結果、GIPから骨組織へのシグナルは、直接骨に発現する受容体を介するのではなく、間接的に作用している可能性があり、介在するその他の液性因子などが考えられた。
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Enteroendocrine K-cells exert complementary effects to control bone quality and mass in mice.2020
Author(s)
Gobron B, Bouvard B, Vyavahare S, Blom LVV, Pedersen KK, Windeløv JA, Boer GA, Harada N, Zhang S, Shimazu-Kuwahara S, Wice B, Inagaki N, Legrand E, Flatt PR, Chappard D, Hartmann B, Holst JJ, Rosenkilde MM, Irwin N, Mabilleau G.
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Journal Title
J Bone Miner Res.
Volume: 00
Issue: 7
Pages: 00-00
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Medium-chain triglyceride diet stimulates less GIP secretion and suppresses body weight and fat mass gain compared with long-chain triglyceride diet.2019
Author(s)
Murata Y, Harada N, Yamane S, Iwasaki K, Ikeguchi E, Kanemaru Y, Harada T, Sankoda A, Shimazu-Kuwahara S, Joo E, Poudyal H, Inagaki N.
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Journal Title
Am J Physiol Endocrinol Metab.
Volume: 317(1)
Related Report
Peer Reviewed / Open Access
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