| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We analyzed the phenotype of osteoblast-specific GIP receptor-deficient mice. In osteoblast-specific GIP receptor-deficient mice, there was no significant difference in the expression of GIP receptors in the following organs: bone, islets, brain, intestine, visceral fat, subcutaneous fat, and brown fat. Whole body bone length was measured using soft X-rays, but no significant difference was observed. No significant differences were found in glucose tolerance, GIP, or insulin secretion capacity. μCT analysis was performed to analyze bone density, but no significant differences were found. We confirmed GIP receptor expression in osteoblast culture, osteoclast culture, and cell line, but GIP receptor expression could not be confirmed using primary culture.
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