Association of diabetes mellitus with peripheral artery disease
| Project/Area Number |
18K16199
|
|---|
| Research Category |
Grant-in-Aid for Early-Career Scientists
|
| Allocation Type | Multi-year Fund |
|---|
| Review Section |
Basic Section 54040:Metabolism and endocrinology-related
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2018-04-01 – 2022-03-31
|
| Project Status |
Completed (Fiscal Year 2021)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 末梢動脈疾患 / 糖尿病 |
|---|
| Outline of Final Research Achievements |
Diabetes mellitus was more common in peripheral artery disease than in coronary artery disease. In patients with critical limb ischemia (chronic limb-threatening ischemia), loss of pressure sensation and dialysis-dependent renal failure were associated with the severe ischemia of asymptomatic contralateral limbs. In patients with intermittent claudication, younger patients had poor cardiovascular risk control and had a higher risk ratio for mortality relative to the same-aged nationals. Among patients who underwent endovascular repair for aortic aneurysm, those with diabetes mellitus had a higher incidence rate of all-cause mortality and cardiovascular events.
|
| Academic Significance and Societal Importance of the Research Achievements |
末梢動脈疾患と冠動脈疾患は同じ心血管疾患に属するが、その背景は大きく異なっており、とくに糖尿病の合併頻度は末梢動脈疾患で明らかに高かった。末梢動脈疾患と冠動脈疾患は別の疾患であり、冠動脈疾患の知見は末梢動脈疾患にはそのまま当てはまらない可能性があり、末梢動脈疾患自身のエビデンスの確立が不可欠である。本研究により末梢動脈疾患と糖尿病との関連の一端が明らかとなった。今回の知見は今後の診療戦略に貢献できる可能性がある。
|
Report
(5 results)
Research Products
(8 results)
