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Association of diabetes mellitus with peripheral artery disease

Research Project

Project/Area Number 18K16199
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionOsaka University

Principal Investigator

TAKAHARA Mitsuyoshi  大阪大学, 医学系研究科, 寄附講座講師 (00751067)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords末梢動脈疾患 / 糖尿病
Outline of Final Research Achievements

Diabetes mellitus was more common in peripheral artery disease than in coronary artery disease. In patients with critical limb ischemia (chronic limb-threatening ischemia), loss of pressure sensation and dialysis-dependent renal failure were associated with the severe ischemia of asymptomatic contralateral limbs. In patients with intermittent claudication, younger patients had poor cardiovascular risk control and had a higher risk ratio for mortality relative to the same-aged nationals. Among patients who underwent endovascular repair for aortic aneurysm, those with diabetes mellitus had a higher incidence rate of all-cause mortality and cardiovascular events.

Academic Significance and Societal Importance of the Research Achievements

末梢動脈疾患と冠動脈疾患は同じ心血管疾患に属するが、その背景は大きく異なっており、とくに糖尿病の合併頻度は末梢動脈疾患で明らかに高かった。末梢動脈疾患と冠動脈疾患は別の疾患であり、冠動脈疾患の知見は末梢動脈疾患にはそのまま当てはまらない可能性があり、末梢動脈疾患自身のエビデンスの確立が不可欠である。本研究により末梢動脈疾患と糖尿病との関連の一端が明らかとなった。今回の知見は今後の診療戦略に貢献できる可能性がある。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020 2019

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 5 results) Presentation (2 results) (of which Invited: 2 results)

  • [Journal Article] Association of Age with Mortality Rate after Femoropopliteal Endovascular Therapy for Intermittent Claudication2022

    • Author(s)
      Takahara Mitsuyoshi、Soga Yoshimitsu、Fujihara Masahiko、Kawasaki Daizo、Kozuki Amane、Iida Osamu
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 29 Issue: 4 Pages: 474-481

    • DOI

      10.5551/jat.62356

    • NAID

      130007992292

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2022-04-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Features of asymptomatic contralateral limb in patients with chronic limb-threatening ischemia2022

    • Author(s)
      Takahara Mitsuyoshi、Iida Osamu、Soga Yoshimitsu、Kodama Akio、Terashi Hiroto、Azuma Nobuyoshi
    • Journal Title

      Journal of Cardiology

      Volume: 79 Issue: 1 Pages: 153-160

    • DOI

      10.1016/j.jjcc.2021.08.021

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical features and prognosis of patients with and without diabetes mellitus undergoing endovascular aortic aneurysm repair2022

    • Author(s)
      Takahara Mitsuyoshi、Iida Osamu、Tazaki Junichi、Nishikawa Ryusuke、Nanto Kiyonori、Chiba Yoshiro、Sakamoto Kazuhisa、Kinoshita Makoto、Takahashi Naoki、Kamihira Satoshi、Yamaoka Terutoshi、Higami Hirooki、Nakane Takeichiro、Ohmine Takahiro、Guntani Atsushi
    • Journal Title

      BMC Endocrine Disorders

      Volume: 22 Issue: 1 Pages: 92-92

    • DOI

      10.1186/s12902-022-01008-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Presentation Pattern of Lower Extremity Endovascular Intervention versus Percutaneous Coronary Intervention2020

    • Author(s)
      Takahara Mitsuyoshi、Iida Osamu、Kohsaka Shun、Soga Yoshimitsu、Fujihara Masahiko、Shinke Toshiro、Amano Tetsuya、Ikari Yuji、on behalf of the J-EVT and J-PCI investigators
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 27 Issue: 8 Pages: 761-768

    • DOI

      10.5551/jat.53330

    • NAID

      130007883653

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2020-08-01
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inverse association of diabetes and dialysis with the severity of femoropopliteal lesions and chronic total occlusion: a cross-sectional study of 2056 cases2020

    • Author(s)
      Takahara Mitsuyoshi、Soga Yoshimitsu、Fujihara Masahiko、Kawasaki Daizo、Kozuki Amane、Iida Osamu
    • Journal Title

      BMC Cardiovascular Disorders

      Volume: 20 Issue: 1 Pages: 514-514

    • DOI

      10.1186/s12872-020-01805-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diabetes mellitus and other cardiovascular risk factors in lower-extremity peripheral artery disease versus coronary artery disease: an analysis of 1,121,359 cases from the nationwide databases2019

    • Author(s)
      Takahara Mitsuyoshi、the J-EVT and J-PCI investigators、Iida Osamu、Kohsaka Shun、Soga Yoshimitsu、Fujihara Masahiko、Shinke Toshiro、Amano Tetsuya、Ikari Yuji
    • Journal Title

      Cardiovascular Diabetology

      Volume: 18 Issue: 1 Pages: 155-155

    • DOI

      10.1186/s12933-019-0955-5

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 糖尿病医の視点からみた末梢動脈疾患患者の全身因子2021

    • Author(s)
      高原充佳
    • Organizer
      第62回日本脈管学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と末梢動脈疾患2019

    • Author(s)
      高原充佳
    • Organizer
      第34回日本糖尿病合併症学会・第25回日本糖尿病眼学会総会
    • Related Report
      2019 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2023-01-30  

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